Our research is focused on chemical and technological difficulties of enacting a fast chemical addition of parahydrogen and the radiofrequency pulses required to convert the nuclear orientation of the two hydrogen nuclei in parahydrogen into an alignment in the third adjacent nuclei. Research in this area has already produced two promising molecules. Hyperpolarized succinate can be used to probe the tricarboxylic acid (TCA) cycle for research into metabolic diseases like diabetes and cancer. Hyperpolarized TFPP, tetrafluoroproply 1-13C-propionate, has been developed as a marker to detect fat and is currently being investigated for detecting atherosclerotic plaque.
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Wagner Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Zacharias NM, McCullough CR, Wagner S, Sailasuta N, Chan HR, Lee Y, Hu J, Perman WH, Henneberg C, Ross BD, Bhattacharya P.
J Mol Imaging Dyn. 2016 Jun;6(1). pii: 123.
Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M.
Arterioscler Thromb Vasc Biol. 2016 May;36(5):886-897.
Sims JD, Hwang JY, Wagner S, Alonso-Valenteen F, Hanson C, Taguiam JM, Polo R, Harutyunyan I, Karapetyan G, Sorasaenee K, et al.
J Control Release. 2015 Aug 31;217:92-101.