The Jones Laboratory is interested in the mechanisms underlying the severe hypoxemia (low oxygen levels) seen in patients who develop acute lung injury. Currently, the Jones Lab is using a mouse model to study the relationship between blood flow and inflammation in the lung and the role of IL-1b in ventilation/perfusion mismatching in acute lung injury.
The Jones Laboratory is affiliated with the Women's Guild Lung Institute, Department of Medicine and Division of Pulmonary and Critical Care Medicine.
As a physician-scientist, I have the opportunity to ask questions that are directly informed by the patients I care for in the intensive care unit. I am able to take these questions to the laboratory and utilize the tremendous resources of the research community at Cedars-Sinai to address them in a meaningful way.
The Jones Laboratory is interested in understanding the role of IL-1b as an independent determinant of low oxygen levels during acute lung injury. In our mouse model, we generate lung injury using a combination of a bacterial toxin called LPS and mechanical ventilation.
Pinar IP, Jones HD.
Pulm Circ. 2018 Apr-Jun;8(2):2045894018762242.
Lahiri S, Schlick K, Padrick M, Rinsky B, Gonzalez N, Jones H, Mayer S, Lyden P.
J Neuroimaging. 2018 Jan;28(1):95-98.
Goldfarb M, Bibas L, Bartlettt V, Jones H, Khan N.
Crit Care Med. 2017 Oct;45(10):1751-1761.