I have been involved in women’s cancer research for more than 10 years. The Lawrenson Laboratory focuses on ovarian cancer and ways to detect ovarian cancers earlier and treat these tumors more effectively. In the Lawrenson Lab, a variety of in vitro models, in vivo models, genomic profiling and molecular biology techniques are used to elucidate the function of variants, genes and noncoding biofeatures involved in ovarian cancer development.
Characterizing the transcription factors (TFs) deregulated during tumorigenesis has provided key insights into disease etiology, disease origins and therapeutic targeting for many tumor types; however, in ovarian cancer, researchers know very little about the TF networks responsible for maintaining cell state and viability. The Lawrenson Laboratory has amassed a large compendium of enhancer landscapes (using H3K27ac ChIP-seq) and transcriptomes (using RNA-seq) for ovarian cancer histological subtypes and precursor cells, and we leverage these data to identify master regulators driving the development of ovarian cancers.
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Lawrenson Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Keleman LE, Lawrenson K, Tyrer J, Li Q, Lee JM, Seo JH, Phelan CM, Beesley J, Chen X, Spindler TJ, et al.
Nat Genet. 2015;47(8):888-897.
Lawrenson K, Li Q, Kar S, Seo JH, Tyrer J, Spindler TJ, Lee J, Chen Y, Karst A, Drapkin R, et al.
Nat Commun. 2015 Sep 22;6:8234.
Coetzee SG, Shen HC, Hazelett DJ, Lawrenson K, Kuchenbaecker K, Tyrer J, Rhie SK, Levanon K, Karst A, Drapkin R, et al.
Hum Mol Genet. 2015;24(13):3595-3607