The Sareen laboratory uses stem cells to model diseases and explore tomorrow’s therapeutics. By differentiating stem cells into mature cells such as motor neurons, gastric organoids, and pancreatic beta-islets, we study the cellular signaling that underlies some of today’s most intractable diseases, including ALS, morbid obesity, and diabetes. Using gene editing, bioprinting, and other emerging tools, we seek to correct defects in a dish so that doctors can one day correct diseases in patients.
The Sareen Laboratory is affiliated with the Cedars-Sinai Department of Biomedical Sciences, Board of Governors Regenerative Medicine Institute and Brain Program.
I have extensive experience performing pluripotent and neural stem cell research, as well as generating human induced pluripotent stem cells (iPSC) for re-creating human "disease-in-a-dish" models. I have published high-profile papers on human iPSC-based disease modeling in spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS)."
Replacing the beta cells lost in Type I diabetes is a long-sought goal of regenerative medicine. The Sareen Laboratory uses the latest methods in cell fate guidance, assessment and clinical translation in its efforts to make this a reality.
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sareen Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Rajamani U, Gross AR, Hjelm BE, Sequeira A, Vawter MP, Tang J, Gangalapudi V, Wang Y, Andres AM, Gottlieb RA, Sareen D.
Cell Stem Cell. 2018 May 3;22(5):698-712.
Sances S, Ho R, Vatine G, West D, Laperle A, Myeyr A, Godoy M, Kay PS, Mandefro B, Hatata S, Hinojosa C, Wen N, Sareen D, et al.
Stem Cell Reports. 2018 Apr 10;10(4):1222-1236.
Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, […], Sareen D, et al.
Cell Syst. 2018 Jan 24;6(1)13-24.