Noval Rivas Lab
The Noval Rivas Laboratory led by Magali Noval Rivas, PhD, works to understand how the intestinal microbiome and the mucosal immune responses influence the severity of Kawasaki disease. The microbiome refers to the bacteria, viruses and fungi present in the gastrointestinal tract and their interactions with genes and the immune system. Noval Rivas has demonstrated that murine Kawasaki disease vasculitis is associated with intestinal barrier dysfunction and dysregulated mucosal immune responses. The Noval Rivas Lab investigates how the microbiome contributes to this vascular inflammation. Additionally, the lab researches how interactions between the microbiome and immune cells contribute to oral tolerance breakdown and food allergy development.
The Noval Rivas Laboratory is affiliated with the Infectious and Immunologic Diseases Research Center, Department of Biomedical Sciences and Pediatrics Department.
Personal Statement
As a cellular and molecular immunologist, my focus has been to understand how microbes and the host immune system interact with each other during health and disease. My investigations on the cellular and molecular mechanisms involved in oral tolerance breakdown and food allergy development has led to several breakthroughs, revealing a fundamental and pathological mechanism of regulatory T cells reprograming into a Th2-like phenotype and has evidenced intestinal microbiota dysbiosis associated with food allergy development."
MAGALI NOVAL RIVAS, PHD
Breakthrough Research
- Kawasaki Disease Vasculitis
- Intestinal Permeability and Microbiome in Kawasaki Disease
- Single-Cell Transcriptional Profiling of Murine Abdominal Aorta Aneurysms
- Autophagy and Mitophagy in Murine Kawasaki Disease Vasculitis
- Intestinal Microbiota Signatures and Immune Responses Underlying Oral Tolerance Breakdown During Food Allergy
Publications
Learn more about the recent research publications from the Noval Rivas Lab.
Laboratory Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Noval Rivas Lab, whose dedicated efforts lead to groundbreaking discoveries.
Job Opportunities
We are actively recruiting students and postdocs to be our colleagues and expand lab knowledge and expertise to make important breakthroughs.
Collaborations
The Noval Rivas Lab collaborates with a wide range of investigators within Cedars-Sinai and institutions around the world.
Contact the Noval Rivas Lab
8700 Beverly Blvd.
Davis, Room D4025
Los Angeles, CA 90048