Mathur Lab

The Mathur Laboratory, led by Ruchi Mathur, MD, studies the effects of gastrointestinal microbiota on metabolic diseases such as obesity and diabetes. Defining the role of specific gut flora in the development of obesity and insulin resistance is the focus of the Mathur Lab as well as understanding the effects of the intestinal microbiome on metabolism. In addition to gut bacteria, the Mathur Lab also studies polycystic ovary syndrome and the clinical phenotyping of this disorder.

The Mathur Laboratory is affiliated with the Cedars-Sinai Department of Medicine and the Endocrinology Program.

Microbial fermentation in the human gut. (A) In the absence of H2-utilising methanogens, the build-up of H2 results inhibition of fermentation. (B) In the presence of H2-utilising methanogens, H2 build-up is alleviated, facilitating increased polysaccharide fermentation and increased availability of SCFAs to the host. CH, carbohydrate. Image via: Intestinal methane production is associated with decreased weight loss following bariatric surgery.

Personal Statement

As an academic endocrinologist, I have a specific interest in the relationship between the gastrointestinal tract and the endocrine system. My early projects focused on gastric myoelectrical activity and glycemic control. In collaboration with researchers in the Division of Gastroenterology, we published the first paper confirming a clinical association with polycystic ovary syndrome (PCOS) and irritable bowel syndrome (IBS)."


  • Polycystic Ovary Syndrome Androgens Study
  • Small Intestinal Microbiome Sampling Study
  • Valeant Rifaximin Study
Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Mathur Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Mathur R, Mundi MS, Chua KS, Lorentz PA, Barlow GM, Lin E, Burch M, Youdim A, Pimentel M.

Obes Res Clin Pract. 2016 Nov-Dec;10(6):728-733.

Mathur R, Chua KS, Mamelak M, Morales W, Barlow GM, Thomas R, Stefanovski D, Weitsman S, Marsh Z, Bergman RN, Pimentel M.

Obesity (Silver Spring). 2016 Mar;24(3):576-582.

Barlow GM, Yu A, Mathur R.

Nutr Clin Pract. 2015 Dec;30(6):787-797.


Contact the Mathur Lab

8700 Beverly Blvd.
Davis Building, Suite 5009
Los Angeles, CA 90048