Sutterwala & Cassel Lab
Aberrant activation of the NLRP3 inflammasome is pathological in many acute and chronic inflammatory diseases, including atherosclerosis, Alzheimer’s disease, pulmonary fibrosis and diabetes, and increasingly is being targeted as a potential therapy for these syndromes. As yet, however, not enough is known about exactly how the NLRP3 inflammasome assembles and becomes activated to devise specific interventions.
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sutterwala and Cassel Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Elliott EI, MillerAN, BanothB, IyerSI, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS*, Cassel SL*.
J Immunol. 2018 May;200(9):3027-3052.
Hornick EE, Banoth B, Miller AM, Zacharias ZR, Jain N, Wilson ME, Gibson-Corley KN, Legge KL, Bishop GA, Sutterwala FS*, Cassel SL*.
J Immunol. 2018 Feb 1;200(3):1188-1197.
Ulland TK, Jain N, Hornick EE, Elliott EI, ClayGC, Sadler JJ, Mills KAM, Janowski AM, Volk APD, WangK, Legge KL, GakharL, BourdiM, Ferguson PJ, WilsonME, Cassel SL*, Sutterwala FS*.
Nat Commun. 2016 Oct 25;7:13180.