"Casero Lab is diving into a new area of biomedical research. There is an increasing demand for scientists with different backgrounds to combine their expertise and integrate efforts in the search for new treatments. Keeping with the Cedars-Sinai tradition, the faculty at the Inflammatory Bowel and Immunobiology Research Institute has a longstanding commitment to advance molecular discoveries to the clinic. Their decadeslong effort on caring and screening inflammatory bowel disease (IBD) patients has resulted in an invaluable resource for future translational discoveries. As director of translational multi-omics, my goal is to foster new data-driven synergies and support and streamline the discovery of novel therapeutic approaches."
- Implementation of multi-omics data integration pipelines (genomics, transcriptomics, proteomics, metabolomics and microbial genomics libraries) to identify pathogenic (causative) factors in IBD
- Integration of single-cell, whole-tissue and tissue organoid gene expression profiles for the identification of intrinsic (cell-specific), relational (controlled by the microenvironment) or systemic (tissue-specific) molecular signatures in stem and immune cell biology
- The role of non-coding RNAs on tissue homeostasis and disease pathogenesis
Montel-Hagen A, Seet CS, Li S, Chick B, Zhu Y, Chang P, Tsai S, Sun V, Lopez S, Chen HC, He C, Chin CJ, Casero D, Crooks GM.
Cell Stem Cell. 2019 Mar 7;24(3):376-389.
Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK.
Microbiome. 2017 Aug 18;5(1):105.
Casero D, Sandoval S, Seet CS, Scholes J, Zhu Y, Ha VL, Luong A, Parekh C, Crooks GM.
Nat Immunol. 2015 Dec;16(12):1282-1291.
Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW, Andrews E, Ajami NJ, Bonham KS, Brislawn CJ, Casero D, et al.
Nature. 2019 May;569(7758):655-662.