The Melmed Laboratory focuses on elucidating mechanisms of pituitary tumor development and pathogenesis, translating the study of anterior pituitary function regulation to the clinic and establishing new modalities of diagnosis and treatment for pituitary diseases. Examples of work in the Melmed Lab include acromegaly therapeutic targeting via somatostatin receptor signaling, Cushing disease drug discovery using a zebrafish model for screening of small molecules, and characterization of the human pituitary tumor-transforming gene, critical to pituitary tumor cell cycle outgrowth.
The Melmed Laboratory is affiliated with the Medicine Department and Pituitary Center.
The Melmed Laboratory focuses on pathogenesis and treatment of pituitary tumors, integrating basic science discovery with prospective clinical study of patients with pituitary disease. The clinical and translational training in the Pituitary Center and Melmed Laboratory are ideal nurturing environments for scholarly creativity in pituitary medicine.
- Role of Somatostatin Receptors in Pituitary Function
- Growth Hormone and Colon Cancer
- The Role of Epidermal Growth Factor Receptor in Pituitary Tumor Progression
- Molecular Pathogenesis and Treatment for Pituitary Adenomas
- Vertebrate Hypothalamic-Pituitary Axis
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Melmed Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Nat Rev Endocrinol. 2016 Feb;12(2):90-98.
Chesnokova V, Zonis S, Zhou C, Recouvreaux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S.
Proc Natl Acad Sci USA. 2016 Jun;113(23):E32590-32599.
Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S.
J Clin Endocrinol Metab. 2015;100(7):2557-2564.