The primary focus of the Koronyo-Hamaoui Laboratory is on early diagnosis and immune-based therapies for Alzheimer's disease (AD). A feasible noninvasive test to identify patients early on, which is essential for effective treatment, is an urgent unmet need. The Koronyo-Hamaoui Laboratory has shown, for the first time, that the hallmark pathology of AD, amyloid-β protein (Aβ) plaque, is present in the retina of human patients beginning at early stages. Furthermore, a unique approach has been developed in this lab to detect plaques in the retina of live rodent models by a noninvasive optical retinal imaging. This innovation unveils new possibilities for investigation of Alzheimer's pathology in the retina. It may also facilitate early diagnosis and noninvasive monitoring of disease progression.
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Koronyo-Hamaoui Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Cedars-Sinai Blog, December 20, 2020
Shi H, Koronyo Y, Rentsendorj A, Regis GC, Sheyn J, Fuchs DT, Kramerov AA, Ljubimov AV, Dumitrascu OM, Rodriguez AR, Barron E, Hinton DR, Black KL, Miller CA, Mirzaei N, Koronyo-Hamaoui M.
Acta Neuropathologica. 2020;139(5), 813-836
Koronyo-Hamaoui M, Sheyn J, Hayden EY, Li S, Fuchs DT, Regis GC, Lopes DHJ, Black KL, Bernstein KE, Teplow DB, Fuchs S, Koronyo Y, Rentsendorj A.
Brain. 2019 pii: awz364.
Li, S, Hayden, EY, Garcia, VJ, Fuchs D-T, Sheyn, J, Daley DA, Rentsendorj, A, Torbati, T, Black, KL, Rutishauser, U, Teplow, DB, Koronyo Y, Koronyo-Hamaoui, M.
Frontiers in Immunology. 2020; 11:49.
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Cedars-Sinai Maxine Dunitz Neurosurgical Institute
127 S. San Vicente Blvd.
Advanced Health Science Pavilion, Eighth Floor, Suite A8103
Los Angeles, CA 90048