Faculty Publications Sept. 4-11
A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators and a Sampling of Recent Media Coverage Featuring Faculty
This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Sept. 4-11. If you have a published paper from this period that does not appear on this list, please contact Sue Marone.
Cedars-Sinai in the News
With Recent Advances, It’s ‘A Very Exciting Time’ for Dementia Researchers | Los Angeles Times
Zaldy Tan, MD, MPH
This one Hobby Is Great for An Aging Brain, According to a New Study | BuzzFeed
Golnaz Yadollahikhales, MD
CRISPR Offers New Hope for Treating Diabetes | Wired
Sonja Schrepfer, MD, PhD
Spaceflight Activates ‘Dark Genome’ in Human Cells, Researcher Says | CNN
Arun Sharma, PhD
Physical Therapists Agree: This Is the #1 Thing That’s Sabotaging Your Recovery | HuffPost
Andrew J. Bach, DO
TL1A Inhibitors: ‘Potentially Transformative’ Option in Inflammatory Bowel Disease | Healio Gastroenterology
Dermot McGovern, MD, PhD
Doctors Downplay PSA Screening for Black Men, Study Finds | Medscape
Dr. Stephen Freedland
Faculty Publications
Biomedical Sciences
Adopting Novel Alternative Methods (NAMs) for Biomedical Research-What Is the Right Approach? Svendsen, Clive N. Cell Stem Cell, August, S1934-5909(25)00329-7.
Ectopic Adipose Tissue in Subsistence Populations With Minimal Coronary Disease, Large Left Atria, and Very Low Rates of Atrial Fibrillation. Thompson, Randall C., Benjamin C. Trumble, Daniel K. Cummings, Angela D. Neunuebel, Paul L. Hooper, Samuel Wann, Adel H. Allam, Frances Neunuebel, Benjamin D. Gans, Samantha I. King, Edmond Seabright, Caleb E. Finch, Margaret Gatz, Kenneth Buetow, Michael I. Miyamoto, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Christopher Ward, Madeleine J. Lee, Ashna Mahadev, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Tianyu Cao, Jonathan Stieglitz, Cameron M. Quick, Gregory S. Thomas, Jagat Narula, Damini Dey, Michael Gurven, and Hillard Kaplan. American Journal of Preventive Cardiology 23 (September): 101271.
Human Cardiac Organoids for Disease Modeling and Drug Discovery. Escopete, Sean, Madelyn Arzt, Maedeh Mozneb, Jemima Moses, and Arun Sharma. Trends in Molecular Medicine, September, S1471-4914(25)00192-3.
Development and Analytical Validation of a Multiplex Diagnostic qPCR-Array as a Potential Application in Predicting the Response to Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer. Sakatani, Toru, Sunao Tanaka, Kaoru Murakami, Francisco Aguilar, Owen T. M. Chan, Catherine Bresee, Daniel J. Luthringer, Charles J. Rosser, Wayne Hogrefe, and Hideki Furuya. Translational Oncology 61 (September): 102528.
Cardiac Surgery
Analysis of United Network for Organ Sharing: Neurodevelopmental Outcomes of Mechanical Circulatory Support as a Bridge-to-Transplantation in Pediatric Heart Transplant Recipients. Bilgili, Ahmet, Omar M. Sharaf, Liam Kugler, Tyler Kashuv, Zachary Brennan, Giles J. Peek, Mark Steven Bleiweis, and Jeffrey Phillip Jacobs. World Journal for Pediatric & Congenital Heart Surgery, September, 21501351251341194.
Analysis of UNOS: Trends in Heart Transplantation for Adults With Congenital Heart Disease in the United States Over 35 Years - A Comparison of Two Eras. Sharaf, Omar M., Ahmet Bilgili, Lindsey M. Brinkley, Sean Kwak, Zachary Brennan, Giles J. Peek, Mark Steven Bleiweis, and Jeffrey Phillip Jacobs. World Journal for Pediatric & Congenital Heart Surgery, September, 21501351251345797.
Cardiology
The Electrophysiology Lab of the Future. Cochran, John, and Michael M. Shehata. The Journal of Innovations in Cardiac Rhythm Management 16 (8): 6391–97.
Artificial Intelligence Automation of Echocardiographic Measurements. Sahashi, Yuki, Hirotaka Ieki, Victoria Yuan, Matthew Christensen, Milos Vukadinovic, Christina Binder-Rodriguez, Justin Rhee, James Y. Zou, Bryan He, Paul Cheng, and David Ouyang. Journal of the American College of Cardiology, August, S0735-1097(25)07343-7.
Impact of Mode of Delivery on Maternal and Fetal Outcomes in Pregnant Patients With Heart Failure or Pulmonary Hypertension. Majmundar, Monil, Kunal N. Patel, Tasveer Khawaja, Rajkumar Doshi, Harshvardhan Zala, Ankur Kalra, Megan McKee Thomas, Matthew Lippmann, and Martha Gulati. American Journal of Preventive Cardiology 23 (September): 101263.
Changing Clinical Perspectives on Sex and Healthcare Disparities in Ischaemic Heart Disease. Maas, Angela, Edina Cenko, Viola Vaccarino, Irene Göttgens, Maria Bergami, Olivia Manfrini, Lina Badimon, Guiomar Mendieta, Sabine Oertelt-Prigione, Zorana Vasiljevic-Pokracic, Maria Dorobantu, Marija Vavlukis, Bela Merkely, Martha Gulati, and Raffaele Bugiardini. The Lancet Regional Health - Europe 56 (September): 101370.
Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy. Ray, Mitali, Lacey W. Heinsberg, Rebecca B. McNeil, William A. Grobman, Amir Lueth, Robert M. Silver, C. Noel Bairey Merz, Lisa D. Levine, Lynn M. Yee, Daniel E. Weeks, Yvette P. Conley, and Janet M. Catov. Obstetrics and Gynecology, September.
Rationale and Design of the Comparative Effectiveness of ICD Versus Non-ICD Therapy in Contemporary Heart Failure Patients at a Low Risk for Arrhythmic Death (CONTEMP-ICD) Trial. Goldenberg, Ilan, Wojciech Zareba, Justin A. Ezekowitz, Christine Albert, Jeffrey D. Alexis, Lisa Anderson, Elijah R. Behr, James Daubert, Katherine E. Di Palo, Kenneth A. Ellenbogen, Dillon J. Dzikowicz, Joseph M. Harrington, Eileen Hsich, David T. Huang, James L. Januzzi, Anas Jawaid, Valentina Kutyifa, Anuradha Lala-Trindade, Alex Nakonechnyi, Anekwe Onwuanyi, Ileana L. Piña, Roopinder K. Sandhu, Samuel Sears, Jakub Sroubek, Tina Baykaner, Robert Strawderman, Christopher Beck, and Javed Butler. American Heart Journal, September, S0002-8703(25)00320-5.
Artificial Intelligence-Guided Coronary Computed Tomography Angiography: Treatment Recommendations Versus Real-World Prescriptions. Cramer, Sophie H. M., Jason H. Cole, Matthew J. Budoff, Ronald P. Karlsberg, Himanshu Gupta, Lance E. Sullenberger, Habib Rahban, Kevin M. Woods, Jeffrey R. Uzzilia, Scott L. Purga, Melissa Aquino, Paul Knaapen, Andrew D. Choi, and Nick S. Nurmohamed. European Journal of Preventive Cardiology, September, zwaf568.
Electrocardiographic Features of Left Bundle Branch Block Following Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy. Freedman, Benjamin L., Divya Velury, Libin Wang, Austin Burrows, Charles Miller, Eli Simsolo, Christopher Firely, Benjamin Koethe, Hassan Rastegar, Barry J. Maron, Martin S. Maron, Ethan J. Rowin, and Christopher Madias. Heart Rhythm, September, S1547-5271(25)02846-2.
Patient and Physician Perspectives on Cardiovascular Risk: A Multicenter Survey of Communication Gaps Among Hospitalized Patients in Spain. Górriz-Magaña, Juan, Ramon Maruri-Sánchez, Ane Elorriaga, Nahikari Salterain-González, Alicia Prieto-Lobato, Raúl Gascueña Rubia, Isabel Monedero Sánchez, Ana Elvira- Laffond, Miguel Lapena Reguero, Amanda Leandro Barros, Cristina Villabona Rivas, Alejandro Gutiérrez Fernández, César Jiménez Méndez, Silvia Prieto-González, María Melendo-Viu, Blanca Alcón Durán, Emilio Blanco López, Clara Bonanad Lozano, Alejandro Durante-López, Anna Carrasquer, Pedro Martínez Losas, Teresa Alvarado Casas, Pedro Pájaro Merino, Victor Juárez Olmos, Javier Lopez-Pais, Michelle M. Kittleson, Pablo Díez-Villanueva, and Jordi Bañeras-Rius. Circulation. Cardiovascular Quality and Outcomes, September, e011837.
Reply: Did the ACURATE Neo2 Fail or Did We Fail the Valve? Gupta, Aakriti, Michael J. Reardon, Tarun Chakravarty, and Raj R. Makkar. Journal of the American College of Cardiology 86 (11): 841–42.
Computational Biomedicine
The Tree-Based Pipeline Optimization Tool: Tackling Biomedical Research Problems With Genetic Programming and Automated Machine Learning. Hernandez, Jose Guadalupe, Anil Kumar Saini, Attri Ghosh, and Jason H. Moore. Patterns (New York, N.Y.) 6 (7): 101314.
County-Level Socioeconomic Status, Rurality, and Second Primary Cancer Risk Among Breast Cancer Survivors in the United States. Ho, Katherine, Carolyn Brandt, Jessica Li, Geetanjali Datta, Justin X. Moore, Lene H. S. Veiga, Gretchen L. Gierach, Amy Berrington de González, Jacqueline B. Vo, and Cody Ramin. Cancer Causes & Control: CCC, September.
Medicine
Pathogen Reduction Diminishes the Protective Effects of Platelets on Endothelial Barrier Permeability in Vitro. Nair, Alison B., Byron Miyazawa, Alpa Trivedi, Lindsay Vivona, Alexander Fields, Kimberly Herrera, Lucy Z. Kornblith, Joseph Cuschieri, and Shibani Pati. Blood Vessels, Thrombosis & Hemostasis 2 (3): 100058.
Changing Landscape of Steatotic Liver Diseases and Liver Fibrosis in the United States During the COVID-19 Pandemic. Attia, Abdelrahman M., Mohammad Saeid Rezaee-Zavareh, Yee Hui Yeo, Minsun Kwak, Hyunseok Kim, Mazen Noureddin, and Ju Dong Yang. Hepatology Communications 9 (9): e0806.
ERS/EULAR Clinical Practice Guidelines for Connective Tissue Diseases Associated Interstitial Lung Disease. Antoniou, Katerina M., Oliver Distler, Ana-Maria Gheorghiu, Catharina C. Moor, Jens Vikse, Nikoleta Bizymi, Ilaria Galetti, Graham Brown, Elena Bargagli, Yannick Allanore, Tamera J. Corte, Philippe Dieudé, Vincent Cottin, Benjamin A. Fisher, Aurelie Fabre, Jon T. Giles, Michael Kreuter, Ingrid E. Lundberg, Venerino Poletti, Britta Maurer, Elisabetta A. Renzoni, Ulf Müller-Ladner, Mary E. Strek, Nicola Sverzellati, Paul Studenic, Jibril Mohammed, Blin Nagavci, Tanja Stamm, Thomy Tonia, Bruno Crestani, and Anna-Maria Hoffmann-Vold. Annals of the Rheumatic Diseases, September, S0003-4967(25)04320-1.
ERS/EULAR Clinical Practice Guidelines for Connective Tissue Disease-Associated Interstitial Lung Disease Developed by the Task Force for Connective Tissue Disease-Associated Interstitial Lung Disease of the European Respiratory Society (ERS) and the European Alliance of Associations for Rheumatology (EULAR) Endorsed by the European Reference Network on Rare Respiratory Diseases (ERN-LUNG). Antoniou, Katerina M., Oliver Distler, Ana-Maria Gheorghiu, Catharina C. Moor, Jens Vikse, Nikoleta Bizymi, Ilaria Galetti, Graham Brown, Elena Bargagli, Yannick Allanore, Tamera J. Corte, Philippe Dieudé, Vincent Cottin, Benjamin A. Fisher, Aurelie Fabre, Jon T. Giles, Michael Kreuter, Ingrid E. Lundberg, Venerino Poletti, Britta Maurer, Elisabetta A. Renzoni, Ulf Müller-Ladner, Mary E. Strek, Nicola Sverzellati, Paul Studenic, Jibril Mohammed, Blin Nagavci, Tanja Stamm, Thomy Tonia, Bruno Crestani, and Anna-Maria Hoffmann-Vold. The European Respiratory Journal, September, 2500896.
Pre-Surgery Gut Microbial Diversity and Abundance Are Associated With Post-Surgery Onset of Cachexia in Colorectal Cancer Patients: The ColoCare Study. Ilozumba, Mmadili N., Maria F. Gomez, Tengda Lin, Caroline Himbert, June L. Round, W. Zac Stephens, Christy A. Warby, Sheetal Hardikar, Christopher I. Li, Jane C. Figueiredo, Victoria Damerell, Gary C. Fillmore, Bartley Pickron, Adetunji T. Toriola, David Shibata, Andreana N. Holowatyj, Christoph Kahlert, Kamya Sankar, Erin M. Siegel, Jolanta Jedrzkiewicz, Biljana Gigic, Doratha A. Byrd, Jennifer Ose, and Cornelia M. Ulrich. Cancer Causes & Control: CCC, September.
PTPN22-CD45 Dual Phosphatase Retrograde Feedback Enhances TCR Signaling and Autoimmunity. Yang, Shen, Eugenio Santelli, Carlos G. Gonzalez, Wade T. Johnson, Irene V. Choi, Chuling Zhuang, Myungja Ro, Leigh-Ana M. Rossitto, I.-Shing Yu, Shu-Wha Lin, Yuan Zhan, Qinwei Chen, Jonathan D. Yoshihara, Daniel J. Wallace, Caroline A. Jefferies, Michifumi Yamashita, David J. Gonzalez, Richard I. Ainsworth, Nisarg J. Shah, Stephanie M. Stanford, and Nunzio Bottini. Science Advances 11 (36): eadw2568.
Relationship Between Hypothyroidism, Risk of Small Intestinal Bacterial Overgrowth, and Duodenal Microbiome Alterations. Wei, Margaret, Sepideh Mehravar, Gabriela Leite, Parnian Naji, Gillian M. Barlow, Ava Hosseini, Mohamad Rashid, Maritza Sanchez, Cristina M. Fajardo, Mark Pimentel, and Ruchi Mathur. The Journal of Clinical Endocrinology and Metabolism, September, dgaf495.
Protocol for Live-Cell Calcium Imaging of Human Lung Microvascular Endothelial Vessel-on-a-Chip Model. Ariyasinghe, Nethika, Jean-Pierre Amoakon, and Anjaparavanda P. Naren. STAR Protocols 6 (3): 104068.
Isatuximab for Relapsed and/or Refractory AL Amyloidosis: Results of a Prospective Phase 2 Trial (SWOG S1702). Parker, Terri, Adam Landon Rosenthal, Vaishali Sanchorawala, Heather J. Landau, Erica L. Campagnaro, Prashant Kapoor, Natalia Neparidze, Saulius K. Girnius, Patrick Hagen, Emma C. Scott, Antje Hoering, Brian G. M. Durie, and Robert Z. Orlowski. Blood, September, blood.2024027962.
Tumor Microenvironment Differences Between Diagnostic and Relapsed Classic Hodgkin Lymphoma Revealed by scRNA-Seq. Yin, Yifan, Shinya Rai, Aixiang Jiang, Alexander M. Xu, Luke O’Brien, Adèle Telenius, Jan Delabie, Lauren C. Chong, Stacy S. Hung, Akil A. Merchant, David W. Scott, Kerry J. Savage, Tomohiro Aoki, and Christian Steidl. Blood Advances, September, bloodadvances.2025017107.
Effect of Aspirin on Grip Strength and Gait Speed in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study. Phyo, Aung Zaw Zaw, Sara E. Espinoza, Suzanne G. Orchard, Rory Wolfe, Anne M. Murray, Robyn L. Woods, and Joanne Ryan. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, September, glaf198.
OBGYN
Disparities in Racial and Ethnic Representation in Clinical Trials for FDA-Approved Treatments of Endometriosis. Meyer, Raanan, Jamila Piri, Neta Oranim, Raine Ngo, and Gabriel Levin. BJOG: An International Journal of Obstetrics and Gynaecology, July.
Orthopaedics
Effect of Social Deprivation on Treatment Strategy and Patient-Reported Outcomes of Proximal Humerus Fractures. Gutbrod, Joseph T., Zachery Hong, Christopher G. Herbosa, Dustin Stwalley, Jenna-Leigh Wilson, and Anna N. Miller. The Journal of the American Academy of Orthopaedic Surgeons, August.
International External Validation of the SORG Machine Learning Algorithm for Predicting Sustained Postoperative Opioid Prescription After Anterior Cervical Discectomy and Fusion Using a Taiwanese Cohort of 1,037 Patients. Chen, Yu-Yung, Hung-Kuan Yen, Jui-Yo Hsu, Ta-Chun Lin, Hao-Chen Lin, Chih-Wei Chen, Ming-Hsiao Hu, Olivier Q. Groot, and Joseph H. Schwab. The Spine Journal 25 (9): 2036–48.
Treating Mental and Social Health: A Call for Alternative Payment Models in Orthopaedic Trauma. Lindsey, Caryn. OTA International: The Open Access Journal of Orthopaedic Trauma 8 (4): e423.
Pathology and Laboratory Medicine
Cytologic Atypia Is Predictive of Increased Risk of Malignancy and BRAF Mutations in Thyroid Follicular Neoplasms (Bethesda Category IV). Dean, Maureen A., Francesco Emiliani, Joshua Levy, Nathalie J. Rodrigues Simoes, Daniel Martinez Coconubo, Edward Gutmann, Louis Vaickus, Jonathan Marotti, Darcy A. Kerr, and Xiaoying Liu. Journal of the American Society of Cytopathology, July, S2213-2945(25)00082-1.
Pediatrics
A Clinical and Genotype-Phenotype Analysis of MACF1 Variants. Dekker, Jordy, Rachel Schot, Kimberly A. Aldinger, David B. Everman, Camerun Washington, Julie R. Jones, Jennifer A. Sullivan, Rebecca C. Spillmann, Vandana Shashi, Antonio Vitobello, Anne-Sophie Denommé-Pichon, Anne-Laure Mosca-Boidron, Grazia M. S. Mancini, et al. American Journal of Human Genetics, September, S0002-9297(25)00320-9.
IL-25-Induced Memory Type 2 Innate Lymphoid Cells Enforce Mucosal Immunity. Cortez, Victor S., Sara Viragova, Satoshi Koga, Meizi Liu, Claire E. O’Leary, Roberto R. Ricardo-Gonzalez, Andrew W. Schroeder, Nathan Kochhar, Dedeepya Vaka, Dario Boffelli, Ophir D. Klein, Michael S. Diamond, Hong-Erh Liang, and Richard M. Locksley. Cell, September, S0092-8674(25)00972-9.
Surgery
High-Dose Vitamin C Improves BCG Immunotherapy’s Efficacy in a Murine Ectopic Model of Bladder Cancer. Deyhimfar, Roham, Keykavos Gholami, Iman Menbari Oskouie, Leila Zareian Baghdadabad, Parisa Zahmatkesh, Mohammadreza Shoghi, Gholamreza Mesbah, Fateme Guitynavard, and Seyed Mohammad Kazem Aghamir. Pathology, Research and Practice 275 (August): 156207.
Engineering the Future of Stem Cells in Vascular Reconstruction: A Leap Towards Functional Endothelialized Tissue-Engineered Vascular Conduits. Oubari, Haizam, Yanis Berkane, Maxime Jeljeli, Alexandre G. Lellouch, and David M. Smadja. Stem Cell Reviews and Reports, September.
Obesity as a Chronic Disease: A Narrative Review of Evolving Definitions, Management Strategies, and Cardiometabolic Prioritization. Singh, Vidhi, Jia Sun, Susan Cheng, Alan C. Kwan, and Amanda Velazquez. Advances in Therapy, September.
VATS Versus Robotic Anatomic Pulmonary Resection in a High-Volume Institution: Cost and Outcomes Analysis. Perez, Claire, Lucas Weiser, Justin J. Watson, Allen Razavi, Shruthi Nammalwar, Charles Fuller, Sevannah Soukiasian, Zishi Li, Raffaele Rocco, Andrew R. Brownlee, and Harmik J. Soukiasian. Innovations (Philadelphia, Pa.), September, 15569845251365679.
A Promising Frontier in Cancer Therapy - Combining Endothelial Colony Forming Cells, Nanotechnology, and Hyperthermia for Precision Oncology. Smadja, David M., and Alexandre G. Lellouch. Stem Cell Reviews and Reports, September.
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