Faculty Publications Nov. 7-14

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Nov. 7-14. If you have a published paper from this period that does not appear on this list, please contact Sue Marone.

Cedars-Sinai in the News

Even Exercise Has a Gender Gap | The New York Times 
Martha Gulati, MD 

Want to Lower Your Blood Pressure? Try 5 More Minutes of Exercise | CNN Health
Susan Cheng, MD 

What to Know About SIBO, The Controversial Gut Condition That is Tough to Diagnose | Glamour UK
Mark Pimentel, MD 

Your Resting Heart Rate can Tell You a Lot About Your Health. Here’s What Your Pulse Should be at Every Age | Fortune
Joseph Ebinger, MD 

Overtreatment Common for Older Men With Prostate Cancer | HealthDay 
Timothy Daskivich, MD 

Cancer Detection Rates Improved the Second Year of the Pandemic, But Deficits Remained | Healio HemOnc Today
Uriel Kim, MD

Faculty Publications

Anesthesiology

The Climate Crisis - Actions to Prioritize for Anaesthesiologists. Lawin-O’Brien, Roberta, Elliot S. Schwartz, Hugh Montgomery, Michael Nurok, and Mark Coburn. Current Opinion in Anaesthesiology, November.

Advancing Cancer Therapy With a Heptamethine Carbocyanine Dye-Conjugated Radionuclide Drug. Huang, Mingxing, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang, and Rong Tian. Journal of Materials Chemistry. B, November.

Biomedical Sciences

Integrated Transcriptomic Analyses of Liver and Mammary Gland Tissues Reveals the Regulatory Mechanism Underlying Dairy Goats at Late Lactation When Feeding Rumen-Protected Lysine. Dai, Wenting, Bingqing Han, Yalu Sun, Pengfei Hou, Chong Wang, Weini Li, and Hongyun Liu. International Journal of Molecular Sciences 25 (21): 11376.

The Brain’s First ‘Traffic Map’ Through Unified Structural and Functional Connectivity (USFC) Modeling. Has Silemek, Arzu C., Haitao Chen, Pascal Sati, and Wei Gao. Communications Biology 7 (1): 1477.

Cardiac Surgery

A Historical Perspective and Update on Robotic Mitral Valve Surgery. Chartrain, Amy, Alfredo Trento, George Gill, Dominic Emerson, Wen Cheng, Danny Ramzy, and Joanna Chikwe. Journal of Clinical Medicine 13 (21): 6375.

Transcatheter Repair or Surgery for Functional Mitral Regurgitation. Chikwe, Joanna, and Michelle M. Kittleson. The New England Journal of Medicine 391 (19): 1850–51.

Cardiology

A Systematic Review of Reporting and Handling of Missing Data in Observational Studies Using the UNOS Database. Baker, William L., Timothy Moore, Eric Baron, Michelle Kittleson, William F. Parker, and Abhishek Jaiswal. The Journal of Heart and Lung Transplantation, November, S1053-2498(24)01932-6.

Bayesian Analytical Methods in Cardiovascular Clinical Trials: Why, When, and How. Heuts, Samuel, Michal J. Kawczynski, Ahmed Sayed, Sarah M. Urbut, Arthur M. Albuquerque, John M. Mandrola, Sanjay Kaul, Frank E. Harrell, Andrea Gabrio, and James M. Brophy. The Canadian Journal of Cardiology, November, S0828-282X(24)01130-9.

PACT-3D, a Deep Learning Algorithm for Pneumoperitoneum Detection in Abdominal CT Scans. Chiu, I.-Min, Teng-Yi Huang, David Ouyang, Wei-Che Lin, Yi-Ju Pan, Chia-Yin Lu, and Kuei-Hong Kuo. Nature Communications 15 (1): 9660.

The 2024 Report on the Human Proteome From the HUPO Human Proteome Project. Omenn, Gilbert S., Sandra Orchard, Lydie Lane, Cecilia Lindskog, Charles Pineau, Christopher M. Overall, Bogdan Budnik, Jonathan M. Mudge, Nicolle H. Packer, Susan T. Weintraub, Michael H. A. Roehrl, Edouard Nice, Tiannan Guo, Jennifer E. Van Eyk, Uwe Völker, Gong Zhang, Nuno Bandeira, Ruedi Aebersold, Robert L. Moritz, and Eric W. Deutsch. Journal of Proteome Research, November.

Computational Biomedicine

Expression of Transglutaminase-2 (TGM2) in the Prognosis of Female Invasive Breast Cancer. Blows, Fiona M., H. Raza Ali, Wei Cope, Paul D. P. Pharoah, Claire V. S. Pike, Elena Provenzano, and Peter Coussons. BJC Reports 2 (1): 5.

A Review of Feature Selection Strategies Utilizing Graph Data Structures and Knowledge Graphs. Shao, Sisi, Pedro Henrique Ribeiro, Christina M. Ramirez, and Jason H. Moore. Briefings in Bioinformatics 25 (6): bbae521.

Medicine

Determining the Efficacy of ExThera Seraph100 Blood Filtration in Patients Diagnosed With Pancreatic Cancer Through the Liquid Biopsy. Shishido, Stephanie N., Divya Suresh, George Courcoubetis, Brandon Ye, Emmeline Lin, Jeremy Mason, Ken Park, Michael Lewis, Ruoxiang Wang, Simon K. Lo, Peter Kuhn, and Stephen Pandol. BJC Reports 2 (1): 47.

A Phase Ib Study of Selinexor in Combination With Pembrolizumab in Patients With Metastatic Melanoma. Gouda, Mohamed A., Bettzy Stephen, Yanyan Tian, Anas Alshawa, Dilichukwu O. Chudy Onwugaje, Aya Albittar, Yali Yang, Abdulrazzak Zarifa, Bulent Yilmaz, Serdar Gurses, Ashabari Sprenger, Mohamed H. Derbala, Amanda Brink, Jeffrey Andrew How, Justin Moyers, Sarina A. Piha-Paul, David S. Hong, Funda Meric-Bernstam, Sapna P. Patel, and Isabella Glitza Oliva. Journal of Immunotherapy and Precision Oncology 7 (4): 247–54.

Pan-Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System. Miller, Sean R., Matthew Schipper, Lars G. Fritsche, Ralph Jiang, Garth Strohbehn, Erkin Ötleş, Benjamin H. McMahon, Silvia Crivelli, Rafael Zamora-Resendiz, Nithya Ramnath, Shinjae Yoo, Xin Dai, Kamya Sankar, Donna M. Edwards, Steven G. Allen, Michael D. Green, and Alex K. Bryant. Cancer Medicine 13 (21): e70379.

Automatic Motion Correction for Myocardial Blood Flow Estimation Improves Diagnostic Performance for Coronary Artery Disease in 18F-Flurpiridaz PET-MPI. Builoff, Valerie, Cathleen Huang, Keiichiro Kuronuma, Chih-Chun Wei, Hidesato Fujito, Yuka Otaki, Serge D. Van Kriekinge, Paul Kavanagh, Mark Lemley, Mark C. Hyun, Marcelo Di Carli, Daniel S. Berman, and Piotr J. Slomka. Journal of Nuclear Cardiology, November, 102072.

Cognitive Decline in Cushing’s Syndrome: A Systematic Review. Katragadda, Anila, Jessica Kunadia, Polly Kirsch, Brenda Dorcely, Shruti Shah, Zachary Henig, Asha Job, Richard A. Feelders, and Nidhi Agrawal. Journal of Neuroendocrinology, November, e13466.

Safety and Efficacy of Catheter-Directed Thrombectomy Without Thrombolysis in Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis. Segun-Omosehin, Omotayo, Maya L. Nasser, Joseph Nasr, Ao Shi, Natalie E. Bourdakos, Suresh Seneviratne, Christian A. Than, and Victor F. Tapson. International Journal of Cardiology, November, 132707.

Targeting Ketone Body Metabolism in Mitigating Gemcitabine Resistance. Rohena-Rivera, Krizia, Sungyong You, Minhyung Kim, Sandrine Billet, Johanna Ten Hoeve, Gabrielle Gonzales, Chengqun Huang, Ashley Heard, Keith Syson Chan, and Neil A. Bhowmick. JCI Insight, November, e177840.

Macrophage LRRK2 Hyperactivity Impairs Autophagy and Induces Paneth Cell Dysfunction. Sun, Shengxiang, Miki Hodel, Xiang Wang, Javier De Vicente, Talin Haritunians, Anketse Debebe, Chen-Ting Hung, Changqing Ma, Atika Malique, Hoang N. Nguyen, Maayan Agam, Michael T. Maloney, Marisa S. Goo, Jillian H. Kluss, Richa Mishra, Jennifer Frein, Amanda Foster, Samuel Ballentine, Uday Pandey, Justin Kern, Shaohong Yang, Emebet Mengesha, Iyshwarya Balasubramanian, Annie Arguello, Anthony A. Estrada, Nan Gao, Inga Peter, Dermot P. B. McGovern, Anastasia G. Henry, Thaddeus S. Stappenbeck, and Ta-Chiang Liu. Science Immunology 9 (101): eadi7907.

Impact of Lenalidomide-Bortezomib-Dexamethasone Induction on Patients With Newly Diagnosed Multiple Myeloma and Renal Impairment: Results From the Connect® MM Registry. Ailawadhi, Sikander, Hans C. Lee, James Omel, Kathleen Toomey, James W. Hardin, Cristina J. Gasparetto, Sundar Jagannath, Robert M. Rifkin, Brian G. M. Durie, Mohit Narang, Howard R. Terebelo, Prashant Joshi, Ying-Ming Jou, Jorge Mouro, Edward Yu, and Rafat Abonour. Blood Cancer Journal 14 (1): 198.

Suppression of Intestinal Ticam1 Ameliorated MASH via Akkermansia Muciniphila QAA37749.1 Mediated Betaine Transformation. Li, Zhonglin, Wenkang Gao, Hang Yuan, Xiaoli Pan, Ruiqing Yuan, Weijun Wang, Lei Guan, Lilin Hu, Yue Chen, Zilu Cheng, Ruohang He, Lei Zhang, Bowen Yang, Qingjing Zhu, Minglu Liang, Ekihiro Seki, Rong Lin, Huikuan Chu, and Ling Yang. Biochimica Et Biophysica Acta. Molecular Basis of Disease, November, 167571.

Development of a Deep Learning Algorithm for Paneth Cell Density Quantification for Inflammatory Bowel Disease. Kang, Liang-I., Kathryn Sarullo, Jon N. Marsh, Liang Lu, Pooja Khonde, Changqing Ma, Talin Haritunians, Angela Mujukian, Emebet Mengesha, Dermot P. B. McGovern, Thaddeus S. Stappenbeck, S. Joshua Swamidass, and Ta-Chiang Liu. EBioMedicine 110 (November): 105440.

Mx1-Ing It Up-Mitochondrial Relay for Interferon-Dependent, Unconventional IL-1β Release in SLE Monocytes. Dorfleutner, Andrea, Christian Stehlik, and Caroline A. Jefferies. Immunity 57 (11): 2483–86.

Clearance of P21 Highly Expressing Senescent Cells Accelerates Cutaneous Wound Healing. Gasek, Nathan S., Pengyi Yan, Junyu Zhu, K.-Raman Purushothaman, Taewan Kim, Lichao Wang, Binsheng Wang, William F. Flynn, Mingda Sun, Chun Guo, Billy Huggins, Roshanak Sharafieh, Yueying Zhou, Vojtech Parizek, Tamar Tchkonia, James L. Kirkland, Saranya P. Wyles, and Ming Xu. Nature Aging, November.

Neurology

2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association. Bushnell, Cheryl, Walter N. Kernan, Anjail Z. Sharrief, Seemant Chaturvedi, John W. Cole, William K. Cornwell, Christine Cosby-Gaither, Sarah Doyle, Larry B. Goldstein, Olive Lennon, Deborah A. Levine, Mary Love, Eliza Miller, Mai Nguyen-Huynh, Jennifer Rasmussen-Winkler, Kathryn M. Rexrode, Nicole Rosendale, Satyam Sarma, Daichi Shimbo, Alexis N. Simpkins, Erica S. Spatz, Lisa R. Sun, Vin Tangpricha, Dawn Turnage, Gabriela Velazquez, and Paul Whelton. Stroke, October.

A 40-Week Phase 2B Randomized, Multicenter, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Memantine in Amyotrophic Lateral Sclerosis. Bhai, Salman, Todd Levine, Dan Moore, Robert Bowser, Andrew J. Heim, Maureen Walsh, Aziz Shibani, Zachary Simmons, James Grogan, Namita A. Goyal, Raghav Govindarajan, Yessar Hussain, Tania Papsdorf, Tiffany Schwasinger-Schmidt, Nick Olney, Kim Goslin, Michael Pulley, Edward Kasarskis, Michael Weiss, Susan W. Katz, Suzan Moser, Duaa Jabari, Omar Jawdat, Jeffrey Statland, Mazen M. Dimachkie, Richard Barohn, and Neuromuscular Study Group and Western ALS Consortium Memantine ALS Study Group. Muscle & Nerve, November.

Neurosurgery

Causes of Intracranial Hypotension: Spontaneous, Traumatic, and Iatrogenic Cerebrospinal Fluid Leaks. Cutsforth-Gregory, Jeremy K., Stephanie J. Steel, Wouter I. Schievink, and Ajay A. Madhavan. Neuroimaging Clinics of North America 35 (1): 123–32.

OBGYN

The Impact of Body Mass Index on the Risk of Postoperative Complications Following Myomectomy. Axelrod, Michal, Kacey M. Hamilton, Rebecca Schneyer, Gabriel Levin, Yotam Weiss, Mireille D. Truong, Kelly N. Wright, Matthew T. Siedhoff, and Raanan Meyer. American Journal of Obstetrics and Gynecology, November, S0002-9378(24)01108-6.

Orthopaedics

Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, B.C., Canada. Dionne, Antoine, Majeed Al-Zakri, Hubert Labelle, Julie Joncas, Stefan Parent, Jean-Marc Mac-Thiong, Firoz Miyanji, Baron Lonner, Ali Eren, Patrick Cahill, Stefan Parent, Peter Newton, Daipayan Guha, et al. Canadian Journal of Surgery. Journal Canadien De Chirurgie 67 (6suppl1): S17–76.

Comparison of Elective Implant Removal and Complication Rates Between Mini and Small Fragment Implants for Lateral Malleolar Fixation. Swenson, Riley, Thomas Z. Paull, Zachary A. Rockov, Kevin Huang, Gaonhia Moua, Milton T. M. Little, and Mai P. Nguyen. Injury 55 (12): 112014.

Prevalence and Prognosis of Coronal Malalignment Following Lateral Lumbar Interbody Fusion for Minimally Invasive Treatment of Adult Spinal Deformity. Chan, Andrew K., Shailen G. Sampath, Praveen V. Mummaneni, Paul Park, Juan S. Uribe, Jay D. Turner, Vivian P. Le, Robert K. Eastlack, Richard G. Fessler, Khoi D. Than, Kai-Ming Fu, Michael Y. Wang, Adam S. Kanter, David O. Okonkwo, Pierce D. Nunley, Neel Anand, Gregory M. Mundis, Peter G. Passias, Shay Bess, Christopher I. Shaffrey, Dean Chou, and International Spine Study Group. Spine, November.

Pathology and Laboratory Medicine

De Novo Exostosin-Associated Membranous Nephropathy in Kidney Transplant. Lafaut, Elisabeth P., Pedro Fragoso, Mark Haas, and Sanjeev Sethi. Kidney International Reports 9 (11): 3349–50.

Pediatrics

Expert Opinion on Use of Vagus Nerve Stimulation Therapy in the Management of Pediatric Epilepsy: A Delphi Consensus Study. Wheless, James W., Jeffrey S. Raskin, Anthony L. Fine, Kelly G. Knupp, John Schreiber, Adam P. Ostendorf, Gregory W. Albert, Eric H. Kossoff, Joseph R. Madsen, Prakash Kotagal, Adam L. Numis, Nisha Gadgil, Deborah L. Holder, Elizabeth A. Thiele, and George M. Ibrahim. Seizure 123 (October): 97–103.

The Journal of Hospital Medicine Turns 20. Shah, Samir S. and Journal of Hospital Medicine Editorial Leadership Team. Journal of Hospital Medicine, November.

Surgery

Selective Sentinel Node Dissection in Melanoma With Trends and Future Directions. Pletcher, Eric, and Mark B. Faries. Cancers 16 (21): 3625.

A CLIA/CAP Compliant Noninvasive Laboratory Developed Test for Early Detection of Pancreatic Ductal Adenocarcinoma. Tajbakhsh, Jian, Silvana Debernardi, Oleg Blyuss, Jianhao Bai, Ruifen Weng, Simon Lo, Stephen J. Pandol, Tatjana Crnogorac-Jurcevic, and Nirdesh K. Gupta. The Journal of Molecular Diagnostics: JMD, November, S1525-1578(24)00270-8.

Comparison of Pediatric and Adult Mandibular Fractures: Identifying Differences in Presentation and Management Using a National Trauma Database. Oxford, Madison, Jacqueline Tucker, Dana Goldenberg, Tonya S. King, Kasra Ziai, Cathy Henry, and Jessyka G. Lighthall. The Journal of Craniofacial Surgery, November.

Keep the Engine Running Maintaining Transplant Registry Utility in Liver Transplant. Wisel, Steven A., Justin A. Steggerda, Aleah L. Brubaker, Anji Wall, and Irene K. Kim. American Journal of Transplantation, November, S1600-6135(24)00685-3.

Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study. Montagna, Giacomo, Alison Laws, Massimo Ferrucci, Mary M. Mrdutt, Susie X. Sun, Suleyman Bademler, Hakan Balbaloglu, Nora Balint-Lahat, Maggie Banys-Paluchowski, Andrea V. Barrio, John Benson, Nuran Bese, ICARO Study Group, et al. Journal of Clinical Oncology, November, JCO2401052.

Main Versus Segmental Hepatic Artery Angioembolization in Patients With Traumatic Liver Injuries: A Western Trauma Association Multicenter Study. Nguyen, Peter D., Jeffry Nahmias, Negaar Aryan, Jason M. Samuels, Michael Cripps, Heather Carmichael, Robert McIntyre, Shane Urban, Clay Cothren Burlew, Catherine Velopulos, Shana Ballow, Rachel C. Dirks, Marchall Chance Spalding, Aimee LaRiccia, Michael S. Farrell, Deborah M. Stein, Michael S. Truitt, Heather M. Grossman Verner, Caleb J. Mentzer, T. J. Mack, Chad G. Ball, Kaushik Mukherjee, Georgi Mladenov, Daniel J. Haase, Hossam Abdou, Thomas J. Schroeppel, Jennifer Rodriquez, Miklosh Bala, Natasha Keric, Morgan Crigger, Navpreet K. Dhillon, Eric J. Ley, Tanya Egodage, John Williamson, Tatiana C. P. Cardenas, Vadine Eugene, Kumash Patel, Kristen Costello, Stephanie Bonne, Fatima S. Elgammal, Warren Dorlac, Claire Pederson, Nicole L. Werner, James M. Haan, Kelly Lightwine, Gregory Semon, Kristen Spoor, Laura A. Harmon, and Areg Grigorian. Surgery, November, S0039-6060(24)00884-5.

Versatility of the Pedicled Buccal Fat Flap. Pak, Kaitlynne Y., Wasiq Nadeem, Brandon Yeshoua, Jay Lee, and Jon Mallen-St Clair. The Journal of Craniofacial Surgery, November.

Orbicularis Oculi Myectomy as an Adjunctive Procedure to Modified Selective Neurectomy for Postparalysis Facial Synkinesis: Technical and Safety Considerations. VandeWater, Tracy, Kaitlynne Y. Pak, and Babak Azizzadeh. Facial Plastic Surgery & Aesthetic Medicine, November.

Early Graft Failure Following Lower Extremity Bypass. Baril, Donald T. Journal of Vascular Surgery Cases and Innovative Techniques 10 (6): 101642.

Effectiveness of a Video-Based Intervention in Improving Skin Cancer Risk Awareness and Preventative Behaviors Among a Diverse Population of Solid Organ Transplant Recipients. Parvathala, Neha, Ritika Saranath, Yasaman Pedram, Alison Ly, Autumn Boutin, Jacob Gomez, Shannon Wong-Michalak, Braulio Fernandez, Renee Haughton, Cassidy Hernandez-Tamayo, Jack Rodman, Andrew Kwong, Binh Ngo, Jenny Hu, and Iris Ahronowitz. JAAD International 17 (December): 172–74.

Use of Machine Perfusion in the United States Increases Organ Utilization and Improves DCD Graft Survival in Liver Transplantation. Wisel, Steven A., Justin A. Steggerda, and Irene K. Kim. Transplantation Direct 10 (12): e1726.

Urology

Health-Outcomes and Epidemiologic Research of Transgender Patients Requires Simple, Meaningful Diagnostic Codes: A Retrospective Review of California Emergency Department Visits. Sterling, Joshua, Aleksandra Golos, Sandeep Sandhu, and Maurice M. Garcia. Journal of Surgery and Research 7 (1): 134–40.

Post-Metastasis Survival of Patients With High-Risk Localized and Locally Advanced Prostate Cancer Undergoing Primary Treatment in the United States: A Retrospective Study. Freedland, Stephen J., Luis Fernandes, Francesco De Solda, Nasuh Buyukkaramikli, Suneel D. Mundle, Sharon A. McCarthy, Daniel Labson, Lingfeng Yang, Feng Pan, and Carmen Mir. Targeted Oncology, November.

Overtreatment of Prostate Cancer Among Men With Limited Longevity in the Active Surveillance Era. Daskivich, Timothy J., Michael Luu, John Heard, I.-Chun Thomas, and John T. Leppert. JAMA Internal Medicine, November.

Biomarkers of Treatment Response in Bladder Cancer. Heard, John R., Michael Ahdoot, Dan Theodorescu, and Anirban P. Mitra. Expert Review of Molecular Diagnostics, November, 1–13.