Faculty Publications July 31-Aug. 7

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published July 31-Aug. 7. If you have a published paper from this period that does not appear on this list, please contact Sue Marone.

Cedars-Sinai in the News

Once a Death Sentence, This Heart Condition Is Finally Treatable | The New York Times
Michelle Kittleson, MD 

Why Are so Many Women Athletes Tearing Their ACLs Now? | SELF
Natasha Trentacosta, MD

Once-monthly Octreotide for Acromegaly Safe, Effective, Improves Patient-reported Outcomes | Healio
Laurence Katznelson, MD

Scientists Pinpoint the Exact age When Your Body Starts Aging Faster—And What to Do About It | Prevention
Bert Mandelbaum, MD 

Arthritis Treatment Reduces Painful Flare-Ups, Slows Disease | Newsweek
Nunzio Bottini, MD 

12 Reasons Your Fingers are Swollen and What to Do About It | Prevention
David C. Hay, MD 

This Simple Walking Change Could Add Years to Your Life. Experts Explain Why It Works so Well. | Women’s Health
Bert Mandelbaum, MD 

Faculty Publications

Biomedical Sciences

Preference for Behavior Change Strategies in Randomized Controlled Trials: Evidence From Weight Management. Sobolev, Michael, Julissa Ruiz, Márcio A. Diniz, Hollie Raynor, Gary D. Foster, Aaron R. Seitz, and Sarah-Jeanne Salvy. Contemporary Clinical Trials, July, 108031.

CCN5 Drives Leydig Cell Aging and Testicular Dysfunction: Insights into Fibrosis, Lipid Dysregulation, and Therapeutic Potential. Tan, Xiaoli, Yanghua Xu, Ningjing Ou, Yuzhuo Chen, Wanyi Xia, Emily Xing, Ren Mo, Hao Bo, Zhitao Han, Jiarong Xu, Zepeng Dong, Yingbo Dai, Yuxin Tang, and Liangyu Zhao. Research (Washington, D.C.) 8: 0762.

The Tilt (tt) Mutation of Drosophila Melanogaster Maps to the Cis-Regulatory Region of the Iroquois Complex (Iro-C) Located in the Sosondowah (Sowah) Gene. Gruber, Samuel, Arno Houtman, Hailey Reisert, Mina Amini, Caroline Fiore, Paula Gonzalez, Veronica Han, Aeva Jazic, Mie Kusupholnand, Max Miller, Jiung Nam, Ziqin Wang, Yang Yu, Peter Dong, Allen S. W. Oak, Arun Sharma, and Eric P. Spana. microPublication Biology.

Coronary CT Angiography Evaluation With Artificial Intelligence for Individualized Medical Treatment of Atherosclerosis: A Consensus Statement From the QCI Study Group. Schulze, Kenrick, Anne-Marieke Stantien, Michelle C. Williams, Vassilios S. Vassiliou, Andreas A. Giannopoulos, Koen Nieman, Pál Maurovich-Horvat, Jason M. Tarkin, Rozemarijn Vliegenthart, Jonathan Weir-McCall, Mahmoud Mohamed, Bernhard Föllmer, Federico Biavati, Ann-Christine Stahl, Jakob Knape, Hanna Balogh, Nicola Galea, Ivana Išgum, Armin Arbab-Zadeh, Hatem Alkadhi, Robert Manka, David A. Wood, Edward D. Nicol, Nick S. Nurmohamed, Fabrice M. A. C. Martens, Damini Dey, David E. Newby, and Marc Dewey. Nature Reviews. Cardiology, August.

Hot Topics: Exploring Artificial Intelligence and Inflammatory Memory in the Management of Psoriatic Diseases. Shucheng, Huidi, April W. Armstrong, Liv Eidsmo, and Denis Poddubnyy. The Journal of Rheumatology, August, jrheum.2025-0241.

Thor: A Platform for Cell-Level Investigation of Spatial Transcriptomics and Histology. Zhang, Pengzhi, Weiqing Chen, Tu N. Tran, Minghao Zhou, Kaylee N. Carter, Ibrahem Kandel, Shengyu Li, Xen Ping Hoi, Yuxing Sun, Li Lai, Keith Youker, Qianqian Song, Yu Yang, Fotis Nikolos, Zejuan Li, Keith Syson Chan, John P. Cooke, and Guangyu Wang. Nature Communications 16 (1): 7178.

Cardiac Surgery

Cold Chain Study of Donor Lungs Reminds Us to Consider the Re-Warming Occurring During the Implant Procedure. Parmar, J. S., and P. Catarino. The Journal of Heart and Lung Transplantation, July, S1053-2498(25)02146-1.

Cadaveric Analysis of Valvular Anatomy in the Great Saphenous Vein: Implications for Surgical Planning. Paladichuk, Schafer, Alexander Downs, Zachary Brennan, Tianfu Shang, David Dommermuth, Steve Zeka, Dan Murphy, Ronald Walser, and Tyler J. Wallen. Cureus 17 (7): e87248.

Cardiology

Sizing for Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Anatomy. Jilaihawi, Hasan, Vivek Patel, and Raj Makkar. JACC. Cardiovascular Interventions 18 (14): 1758–61.

Blood Pressure Reduction by Gender and Menopause Status Among Hypertensive Participants of a Mobile Health Cardiovascular Risk Self-Management Program. Morgan, Jayne, Walter Roberts, Helena Lyson, Morgan Meadows, Elizabeth Ofili, Martha Gulati, and Erin D. Michos. American Journal of Preventive Cardiology 23 (September): 101057.

Cardiac Implantable Electronic Device Implantation and Function After Transcatheter Tricuspid Valve Replacement. Braunstein, Eric D., Eli Simsolo, Nabeel Kassam, Ashkan Ehdaie, Raj R. Makkar, Aakriti Gupta, Archana Ramireddy, Raymond H. M. Schaerf, Xunzhang Wang, and Michael Shehata. Heart Rhythm, July, S1547-5271(25)02730-4.

AI-Scending the Scope: Perspectives on the Integration and Utilization of Artificial Intelligence and Machine Learning in Genetic Counseling Graduate Programs. Feuer, Ofir, Kyla Holmes, Sarah Kane, Kathryn M. Curry, Daria Ma, Chloe A. Chatwin, Marie Chuldzhyan, Emily Quinn, and Nicholas Gorman. Journal of Genetic Counseling 34 (4): e70065.

A Multicenter Randomized Controlled Trial of Meditation and Health Education in the Prevention of Cardiometabolic Disease in Black Women. Gaylord-King, Carolyn, Charlie L. Harris, Shichen Xu, John W. Salerno, Kenneth G. Walton, C. Noel Bairey-Merz, Sanford Nidich, and Robert H. Schneider. Journal of Women’s Health (2002), August.

High Residual Gradients After Transcatheter Aortic Valve Implantation in Raphe-Type Bicuspid Aortic Valve Stenosis: Insights From the AD-HOC Registry. Tartaglia, Francesco, Mauro Gitto, Won-Keun Kim, Pier Pasquale Leone, Tommaso Fabris, Chiara De Biase, Giuliano Costa, Nicholas Montarello, Andrea Scotti, Michele Bellamoli, Mesfer Alfadhel, Ofir Koren, Antonio Mangieri, et al. Clinical Research in Cardiology, August.

A Breakthrough With a Burden: Access, Affordability, and the Future of ATTR-CM Therapy. Krumholz, Harlan M., Michelle M. Kittleson, and Kushal T. Kadakia. Journal of the American College of Cardiology 86 (6): 409–11.

Structure, Function, and Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights From HELIOS-B. Kittleson, Michelle M. Journal of the American College of Cardiology 86 (6): 456–58.

Artificial-Intelligence-Assisted CCTA Quantifies Sex Differences in Coronary Atherosclerotic Burden at Low Atheroma Volumes. D’Costa, Zoee, Ronald P. Karlsberg, and Geoffrey W. Cho. International Journal of Cardiology. Heart & Vasculature 60 (October): 101758.

Computational Biomedicine

Mediating Effects of Mental and Physical Health on the Association Between Chronic Disease Conditions and Colorectal Cancer Screening Utilization Among Breast Cancer Survivors. Tsai, Meng-Han, Jacqueline B. Vo, Justin X. Moore, Cody Ramin, Avirup Guha, and Yanbin Dong. PloS One 20 (8): e0328353.

Antibody-Based Multiplex Image Analysis: Standard Analytical Workflows and Tools for Pathologists. Omar, Mohamed, Giuseppe Nicolo’ Fanelli, Fabio Socciarelli, Varun Ullanat, Sreekar Reddy Puchala, James Wen, Alex Chowdhury, Itzel Valencia, Cristian Scatena, Luigi Marchionni, Renato Umeton, and Massimo Loda. Laboratory Investigation; a Journal of Technical Methods and Pathology, July, 104220.

PSCS: Unified Sharing of Single-Cell Omics Data, Analyses, and Results. Hutton, Alexandre, Lizhuo Ai, and Jesse G. Meyer. Journal of Proteome Research, August.

Drug Repurposing for Alzheimer’s Disease Using a Graph-of-Thoughts Based Large Language Model to Infer Drug-Disease Relationships in a Comprehensive Knowledge Graph. Wang, Zhiping Paul, Xi Li, Nicholas Matsumoto, Mythreye Venkatesan, Jui-Hsuan Chang, Jay Moran, Hyunjun Choi, Binglan Li, Yufei Meng, Miguel E. Hernandez, and Jason H. Moore. BioData Mining 18 (1): 51.

Medicine

Diabetes Prevalence and Management Patterns in US Adults, 2001-2023. Hu, Miaojin, Michael H. Le, Yee Hui Yeo, Karn Wijarnpreecha, Alisa Likhitsup, Donghee Kim, and Vincent L. Chen. Acta Diabetologica, July.

Preferences, Acceptability, and Utilization of Multimodal Self-Help Interventions in Adults With Inflammatory Bowel Diseases: A Pragmatic Multicenter Study with Patients and Clinicians. Tse, Chung Sang, Melissa G. Hunt, James D. Lewis, Arthur Ostrov, Samir A. Shah, Hannah W. Fiske, Stephanie M. Burwell, Erin M. Forster, Jill K. J. Gaidos, Robert H. Kuehnel, Emily Sheng, Michelle Lu, Chien-Hsiang Weng, Courtney Benjamin Wolk, Catherine Soto, S. Alandra Weaver, Gil Y. Melmed, Corey A. Siegel, and Welmoed K. van Deen. Inflammatory Bowel Diseases, July, izaf154.

Racial and Ethnic Disparities in Survival Among Patients With Cholangiocarcinoma in the United States: A Systematic Review and Meta-Analysis. Shubin, Andrew D., Phillip J. Leff, Meena M. Tadros, Meng L. Hsieh, David Hsiehchen, Parsia A. Vagefi, Jason Y. Wang, Gonzalo Sapisochin, Adam C. Yopp, Nina N. Sanford, Ju Dong Yang, Amit G. Singal, Madhukar S. Patel, and Nicole E. Rich. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, July.

Updated Demographics Categories to Capture the True Diversity of an International Registry of Rare Disease Patients. Kressin, Nicole, Michael E. Shy, Tara Jones, Nidia Villalpando, and Gita Ramdharry. Therapeutic Advances in Rare Disease 6: 26330040251359676.

Interaction Between Haploinsufficiency of PTPN2 and Patient Microbiome Promotes Autoimmune Arthritis in Mice. Sendo, Sho, Allison J. Vela, Myungja Ro, Deepan Thiruppathy, Elizabeth L. Wilkinson, Zixuan Zhao, Wan-Chen Hsieh, Shen Yang, Roxana Coras, Anne-Sophie Bergot, Monica Guma, Anders Nguyen, David A. McBride, Suzanne Devkota, Ranjeny Thomas, Nisarg J. Shah, Mattias N. D. Svensson, Karsten Zengler, Stephanie M. Stanford, and Nunzio Bottini. Journal of Autoimmunity 156 (July): 103452.

In Reply: Health Inequalities of Early-Onset Gastrointestinal Cancers From 2000 to 2021: Findings Based on the Global Burden of Disease Study 2021. Danpanichkul, Pojsakorn, Krittameth Rakwong, Mazen Noureddin, Donghee Kim, Denise M. Harnois, Ju Dong Yang, Michael B. Wallace, and Karn Wijarnpreecha. Mayo Clinic Proceedings 100 (8): 1447–49.

Multisystem Burden in Cirrhosis: Lessons From a Marginalised Population. Danpanichkul, Pojsakorn, Jeffrey V. Lazarus, Ju Dong Yang, and Amit G. Singal. The Lancet Regional Health. Western Pacific 61 (August): 101645.

COVID-19 Vaccine Booster Uptake and Effectiveness Among Persons with Systemic Autoimmune and Rheumatic Diseases. Ziemba, Yonah C., Eric P. Elkin, Elham Kazemian, Brigid M. Wilson, Hinnah Siddiqui, Cheryl B. Schleicher, Crystal A. Hsiao, David A. Zidar, Lawrence H. Kushi, Jane C. Figueiredo, Jacek Skarbinski, and James M. Crawford. The Journal of Rheumatology, August, jrheum.2025-0535.

Intratumoral Vidutolimod as Monotherapy or in Combination With Pembrolizumab in Patients With Programmed Cell Death 1 Blockade-Resistant Melanoma: Final Analysis From a Phase 1b Study. Milhem, Mohammed M., Yousef Zakharia, Diwakar Davar, Elizabeth I. Buchbinder, Theresa Medina, Adil Daud, Antoni Ribas, Bartosz Chmielowski, Jiaxin Niu, Geoffrey T. Gibney, Kim Margolin, Anthony J. Olszanski, Inderjit Mehmi, Takami Sato, Montaser Shaheen, Luping Zhao, Heather Kelley, Hong Liu, Sujatha Kumar, Dmitri Bobilev, Arthur M. Krieg, James E. Wooldridge, and John M. Kirkwood. Cancer 131 (15): e70022.

Pretransplant Targeting of TNFRSF25 and CD25 Stimulates Recipient Tregs in Target Tissues, Ameliorating GVHD Post-HSCT. McManus, Duneia, Sabrina N. Copsel, Brent J. Pfeiffer, Dietlinde Wolf, Henry Barreras, Symon Ma, Ali Khodor, Seitaro Komai, Marina Burgos da Silva, Hajar Hazime, Miguel Gallardo, Sarah Grace R. Lime, Marcel R. M. van den Brink, Jung-Hyun Park, Maria T. Abreu, Geoffrey R. Hill, Victor L. Perez, and Robert B. Levy. Blood, August, blood.2025028418.

Catalytic Region Mimetics in Na+ /H+ Exchanger Regulatory Factor 4 Suppress Guanylate Cyclase 2C Activity to Regulate Enterotoxin Triggered Diarrhea. Ramananda, Yashaswini, Pramodha Liyanage, Yunjie Huang, Aleksey Porollo, Gerhard Hannig, Anjaparavanda P. Naren, and Kavisha Arora. The Journal of Biological Chemistry, August, 110559.

Autoantibody Profiling to Predict Response to the Anti-PD-1 Therapy, Pembrolizumab, in Rare Tumors. Derbala, M. H., J. Hajjar, B. Stephen, S. A. Gurses, E. Kwiatkowski, P. Budde, H.-D. Zucht, M. Bräutigam, A.-S. Lindemann, B. A. Abhari, M. A. Gouda, L. Castillo, A. Zarifa, J. A. How, E. Rodriguez, J. T. Moyers, D. S. Hong, S. Fu, F. Meric-Bernstam, and A. Naing. ESMO Open 10 (8): 105518.

An IFN/STAT1/CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk in Aspergillus Fumigatus - Infected Mice. Guo, Yahui, Mariano A. Aufiero, Kathleen Am Mills, Simon A. Grassmann, Hyunu Kim, Mergim Gjonbalaj, Paul Zumbo, Audrey Billips, Katrina B. Mar, Yao Yu, Laura Echeverri Tirado, Lena Heung, Amariliz Rivera, Doron Betel, Joseph C. Sun, and Tobias M. Hohl. The Journal of Clinical Investigation, August, e190107.

Eliminating Separase Inhibition Reveals Absence of Robust Cohesin Protection in Oocyte Metaphase II. El Jailani, Safia, Damien Cladière, Elvira Nikalayevich, Sandra A. Touati, Vera Chesnokova, Shlomo Melmed, Eulalie Buffin, and Katja Wassmann. The EMBO Journal, August.

Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment. Chesnokova, Vera, Svetlana Zonis, Richard Ainsworth, Tugce Apaydin, Christian Wong Valencia, Elora C. Greiner, Robert Barrett, Arminja N. Kettenbach, and Shlomo Melmed. Aging Cell, August, e70187.

Neurology

Cognitive and Neuropsychological Trajectories in Patients With Mixed Neurodegenerative Pathologies. Almeida, Francisco C., Gabriel A. Marx, Susan K. Rohde, Mitzi M. Gonzales, Carolina Maldonado-Díaz, Satomi Hiya, Kevin Clare, Jorge Samanamud, Cheyanne C. Slocum, Justin Kauffman, Daniel G. Koenigsberg, Victoria Flores-Almazan, John F. Crary, Kurt Farrell, Charles L. White, Elena V. Daoud, Jamie M. Walker, Tiago Gil Oliveira, and Timothy E. Richardson. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 21 (8): e70575.

Cognitive Impairment and Dementia-Related Diagnoses in Chronic Traumatic Encephalopathy: A Systematic Review and Meta-Analysis. LoBue, Christian, Kevin C. Bickart, Kevin F. Bieniek, Benjamin L. Brett, Hannah Cabrera, Hsueh-Sheng Chiang, Yanel De Los Santos, Mitzi M. Gonzales, John Hart, Roberto Sergio Hernandez, Gabrielle Hromas, Matthew E. Peters, Amber Salter, Jeff Schaffert, Vishal J. Thakkar, Charles L. White, and C. Munro Cullum. Neurology 105 (4): e213934.

Orthopaedics 

Percutaneous Anterior Pelvic Ring Fixation in Addition to Percutaneous Posterior Pelvic Ring Fixation Decreases Postoperative Pain and Narcotic Usage in Hospital for LC1 and LC2 Injuries. Kumaran, Pranit, Julian Wier, Joseph T. Patterson, Jackson Lee, Geoffrey Marecek, Adam Lee, and Joshua L. Gary. Journal of Orthopaedic Trauma, July.

Multiplanar Humeral Shape Changes From Infancy to Adulthood in Patients With Birth-Related Brachial Plexus Palsy: A Cross-Sectional Analysis. Forrest, Euan A., Paige M. Lind, Michael L. Pearl, Katharine E. Alter, and Frances T. Sheehan. Journal of Shoulder and Elbow Surgery, August, S1058-2746(25)00562-2.

Pathology and Laboratory Medicine

Punctate Podocyte IgG Staining Does Not Differentiate Primary From Secondary Minimal Change Disease. Leong, Matthew, Chen Yu Jamie Lee, Michifumi Yamashita, Daisuke Kiyozawa, Man-Hoon Han, and Cynthia C. Nast. Glomerular Diseases 5 (1): 316–27.

Crystal Structure of Fis1 and Bap31 Provides Information on Protein-Protein Interactions at Mitochondria-Associated ER Membranes. Nguyen, Minh Duc, Yonghyeok Kim, Seung-Hyun Bae, Soeun Kim, Hyun Ku Yeo, Nam-Chul Ha, Ginam Cho, Sunghyun Moon, Kwang-Hwi Cho, Hyonchol Jang, Seoung Min Bong, and Byung Il Lee. Communications Biology 8 (1): 1161.

Pediatrics

Evolution of Neonatal Noninvasive Ventilation. Biniwale, Manoj. Seminars in Perinatology 49 (5): 152079.

Challenges With Access to Early Intervention Services Following NICU Discharge in California. Richter, Marinthea, Polly Kellner, Jenny Kwon, Lisa G. Vargas, Manoj Biniwale, Amy Yeh, and Roberta Pineda. American Journal of Perinatology, August.

Radiation Oncology

Long Term Results of NRG Oncology RTOG 9601, a Randomized Trial of Radiation With or Without Anti-Androgens (AAT) in Patients Receiving Salvage Prostate Bed Radiation Therapy Post Prostatectomy. Lukka, Himanshu R., Stephanie L. Pugh, William U. Shipley, Pierre P. Major, Oliver Sartor, Ian S. Dayes, Jean-Paul Bahary, Jason A. Efstathiou, Thomas M. Pisansky, Kenneth L. Zeitzer, Colleen A. F. Lawton, Robert T. Dess, Andrew S. Camarata, Alexander G. Balogh, Luis Souhami, Seth A. Rosenthal, J. Daniel Pennington, Wendy F. Seiferheld, Felix Y. Feng, and Howard M. Sandler. International Journal of Radiation Oncology, Biology, Physics, July, S0360-3016(25)06014-6.

Muscle-Invasive Bladder Cancer: A Watershed Moment. Galsky, Matthew D., Leslie Ballas, and Ashish M. Kamat. Journal of Clinical Oncology, August, JCO2500718.

Surgery 

Osteoradionecrosis of the Jaw-Thinking Outside the Box, a Review of Emerging Treatment Paradigms. Pak, Kaitlynne Y., Alberto Nunez, Harsh Patel, Jay K. Lee, Joel B. Epstein, Allen S. Ho, Dmitry Sheyn, and Jon Mallen-St Clair. The Journal of Craniofacial Surgery, July.

Fasciocutaneous Vascularized Lymph Node Transfer for Head and Neck Lymphedema: A Case Report. Almadani, Hamzah, Hosung Rhyu, Andrew Cantor, and Philip S. Brazio. Microsurgery 45 (6): e70098.

Inter-Hospital Variation in Transfusion Practices for Severe Trauma. Coaston, Troy N., Amulya Vadlakonda, Saad Mallick, Esteban Aguayo, Nam Yong Cho, Galinos Barmparas, Peyman Benharash, and Academic Trauma Research Consortium (ATRIUM). Injury, July, 112630.

Early Outcomes of Endovascular Repair of Aortic Arch Lesions in Zone 0/1 With a Thoracic Branched Endoprosthesis. Sweet, Matthew P., Ali Azizzadeh, Gustavo S. Oderich, William Brinkman, Jon S. Matsumura, Takao Ohki, Sara Zettervall, Shinji Miyamoto, Himanshu J. Patel, and Michael D. Dake. Journal of Vascular Surgery, July, S0741-5214(25)01555-1.

Neonatal Outcomes and the Risk of Congenital Anomalies After Maternal Bariatric Surgery. Lee, William G., Aaron M. Barkhordar, Candace Levian, Amrita Pandit, Amanda Velazquez, Kulmeet Sandhu, Tania F. Esakoff, Eugene S. Kim, and Eveline H. Shue. The Journal of Surgical Research 314 (August): 176–84.

Glisson’s Capsule Invasion as a Risk Factor of Multifocal Intrahepatic Recurrence After Hepatectomy for Hepatocellular Carcinoma: A Retrospective Single-Center Cohort Study. Cherchi, Vittorio A., Marco Ventin, Umberto Baccarani, Lorenzo Marini, Lorenzo D’Alì, Angelica Tulisso, Pierluigi Visentin, Serena Battista, Vittoria Morinelli, Pietro Matucci Cerinic, Mattia Zambon, Davide Muschitiello, Giada Aveni, Carla Di Loreto, Dario Lorenzin, and Giovanni Terrosu. Updates in Surgery, August.

Regarding ‘Relationship Among Postoperative Arthritis, Ischemic Changes in Subchondral Bone on Postoperative MR Images, and Central Impaction Fragment on Preoperative Computed Tomography Scans in Patients With Intra-Articular Distal Radius Fracture: A Preliminary Report.’ Kuschner, Stuart H. Journal of Hand Surgery Global Online 7 (5): 100801.

Urology

Untangling Surgical Gesture Analysis-Are We Even Speaking the Same Language? A Systematic Review. Olsen, Rikke Groth, Annarita Ghosh Andersen, Andrew J. Hung, Morten Bo Søndergaard Svendsen, Julia Abildgaard Dagnæs-Hansen, Lars Konge, Andreas Røder, and Flemming Bjerrum. Surgical Endoscopy, July.

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