Faculty Publications Feb. 6-13

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 6-13. If you have a published paper from this period that does not appear on this list, please contact Sue Marone.

Cedars-Sinai in the News

Doctor Jun Gong Shares What Modern Medicine Is Doing About Cancer, Ahead of World Cancer Day | KTLA-TV 
Jun Gong, MD 

Researchers Track Firefighter Exposure Following LA Devastation | Spectrum News 1
Sara Ghandehari, MD 

During Fires, LA Burn Centers Braced for Crisis That Never Came | Los Angeles Times 
Vimal Murthy, MD 

Is Thyroid Cancer Overdiagnosed? | The ASCO Post
Zachary Zumsteg, MD 

CIBMTR Ranks Cedars-Sinai Cancer Among top Transplant Programs in the US | Managed Healthcare Executive
Ronald Paquette, MD 

Cedars-Sinai is Using AI to Predict Pancreatic Cancer in Black Patients | BlackDoctor
Debiao Li, PhD; Stephen Pandol, MD; Dan Theodorescu, MD, PhD 

Can a Blood Test Diagnose Hypertrophic Cardiomyopathy? | Health Central
Florian Rader, MD 

Cedars-Sinai’s New AI Chief Digs Into the Data | HealthLeaders
Mouneer Odeh, MA

Faculty Publications

Biomedical Sciences

Diet and Survival After a Diagnosis of Ovarian Cancer: A Pooled Analysis From the Ovarian Cancer Association Consortium. Nagle, Christina M., Torukiri I. Ibiebele, Renhua Na, Elisa V. Bandera, Daniel Cramer, Jennifer A. Doherty, Graham G. Giles, Marc T. Goodman, Gillian E. Hanley, Holly R. Harris, Allan Jensen, Susanne K. Kjaer, Alice Lee, Valerie McGuire, Roger L. Milne, Bo Qin, Jean Richardson, Naoko Sasamoto, Joellen M. Schildkraut, Weiva Sieh, Kathryn L. Terry, Linda Titus, Britton Trabert, Nicolas Wentzensen, Anna H. Wu, Andrew Berchuck, Malcolm C. Pike, Celeste Leigh Pearce, Penelope M. Webb, and Multidisciplinary Ovarian Cancer Outcomes Group and Ovarian Cancer Association Consortium. The American Journal of Clinical Nutrition, February, S0002-9165(25)00072-3.

Novel CT-Derived Markers for Enhanced Long-Term Risk Stratification in the Planning of TAVR for Aortic Stenosis. Lorenzatti, Daniel, Annalisa Filtz, Jolien Geers, Kajetan Grodecki, Vita Jaspan, Colin Pierce, Matthew J. Miller, Christine Park, Alexandrina Danilov, Ron Blankstein, Thomas A. Treibel, João L. Cavalcante, Leslee J. Shaw, Marc R. Dweck, Piotr J. Slomka, Damini Dey, and Leandro Slipczuk. Journal of Cardiovascular Computed Tomography, February, S1934-5925(25)00010-3.

High-Risk Plaque Features and Perivascular Inflammation. Kinoshita, Daisuke, Keishi Suzuki, Daichi Fujimoto, Takayuki Niida, Yoshiyasu Minami, Damini Dey, Hang Lee, Iris McNulty, Junya Ako, Maros Ferencik, Tsunekazu Kakuta, and Ik-Kyung Jang. Journal of Cardiovascular Computed Tomography, February, S1934-5925(25)00012-7.

Cardiac Surgery

Impact of Voluntary Exercise on Systemic Inflammation in a 2-Hit Model Heart Failure With Preserved Ejection Fraction. Quiriarte, Heather, Eunhan Cho, Youyoung Kim, Jake E. Doiron, Gregory Davis, James Stampley, Robert C. Noland, Zhen Li, Sanjiv J. Shah, Brian A. Irving, Guillaume Spielmann, David J. Lefer, and Timothy D. Allerton. Journal of the American Heart Association, February, e038789.

Cardiology

Reassessing the Need for Primary Prevention Implantable Cardioverter-Defibrillators in Contemporary Patients With Heart Failure. Goldenberg, Ilan, Justin Ezekowitz, Christine Albert, Jeffrey D. Alexis, Lisa Anderson, Elijah R. Behr, James Daubert, Katherine E. Di Palo, Kenneth A. Ellenbogen, Dillon J. Dzikowicz, Eileen Hsich, David T. Huang, James L. Januzzi, Valentina Kutyifa, Anuradha Lala, Anekwe Onwuanyi, Ileana L. Piña, Roopinder K. Sandhu, Samuel Sears, Jakub Sroubek, Robert Strawderman, Wojciech Zareba, and Javed Butler. Journal of Cardiac Failure, January, S1071-9164(24)00971-0. Note: This article is a joint publication in Heart Rhythm and the Journal of Cardiac Failure. 

Advancing Scientific Communication in Proteomics. Searle, Brian C., Blandine Chazarin, Ben C. Collins, Deepti J. Kundu, Shixia Huang, Qingsong Lin, Yansheng Liu, Teck Yew Low, Julian Saba, Tiannan Guo, Giuseppe Palmisano, and Justyna Fert-Bober. Journal of Proteome Research 24 (2): 381–82.

Diagnosis of Arrhythmogenic Cardiomyopathy in a Young Patient With Recurrent Myocarditis: The Importance of Genetic Testing. Morales, Juana Perez, Ana Spaccavento, Marianna Guerchicoff, Lucrecia Burgos, Juan Pablo Costabel, Eugenio Cingolani, and Alberto Alves de Lima. The American Journal of Cardiology, February, S0002-9149(25)00059-1.

Are the Device Approval Standards Lax? Kaul, Sanjay. JACC. Cardiovascular Interventions 18 (3): 380–84.

Computational Biomedicine

Single-Molecule m6A Detection Empowered by Endogenous Labeling Unveils Complexities Across RNA Isoforms. Guo, Wenbing, Zhijun Ren, Xiang Huang, Jiayin Liu, Jingwen Shao, Xiaojun Ma, Chuanchuan Wei, Yixian Cun, Jialiang He, Jie Zhang, Zehong Wu, Yang Guo, Zijun Zhang, Zhengming Feng, Jianbo He, and Jinkai Wang. Molecular Cell, February, S1097-2765(25)00049-8.

Exome Sequencing Identifies HELB as a Novel Susceptibility Gene for Non-Mucinous, Non-High-Grade-Serous Epithelial Ovarian Cancer. Dicks, Ed M., Jonthan P. Tyrer, Suzana Ezquina, Michelle Jones, John Baierl, Pei-Chen Peng, Michael Diaz, Ellen Goode, Stacey J. Winham, Thilo Dörk, Toon Van Gorp, Anna De Fazio, David D. L. Bowtell, Dale W. Garsed, Kunle Odunsi, Kirsten Moysich, Marina Pavanello, Florentia Fostira, Penelope M. Webb, Jana Soukupová, Paul A. Cohen, Weiva Sieh, Renée Turzanski Fortner, Charite Ricker, Beth Karlan, Ian Campbell, James D. Brenton, Susan J. Ramus, Simon A. Gayther, and Paul D. P. Pharoah. European Journal of Human Genetics: EJHG, February.

Medicine

B7-H3-Liquid Biopsy for the Characterization and Monitoring of the Dynamic Biology of Prostate Cancer. Ju, Yong, Joshua Watson, Jasmine J. Wang, Ying-Tzu Yen, Lilit Gevorkian, Zijing Chen, Kai Han Tu, Brenda Salumbides, Aaron Phung, Chen Zhao, Hyoyong Kim, You-Ren Ji, Ryan Y. Zhang, Junseok Lee, Jun Gong, Kevin Scher, Sungyong You, Jie-Fu Chen, Hsian-Rong Tseng, Yazhen Zhu, and Edwin M. Posadas. Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy 79 (January): 101207.

Isotretinoin-Induced Pill Esophagitis. Hourany, George, Jamil S. Samaan, Amrit K. Kamboj, and Francisco Ibarra. ACG Case Reports Journal 12 (2): e01596.

Fructose-Induced Progression of Steatohepatitis Involves Disrupting Aldolase B-AMPK Signaling in Methionine Adenosyltransferase 1A Deficient Mice. Barbier-Torres, Lucía, María Luque-Urbano, Jyoti Chhimwal, Aaron E. Robinson, David Fernández-Ramos, Fernando Lopitz-Otsoa, Jennifer E. Van Eyk, Oscar Millet, José M. Mato, and Shelly C. Lu. Metabolism: Clinical and Experimental 165 (February): 156154.

CAR-Macrophage Therapy for HER2-Overexpressing Advanced Solid Tumors: A Phase 1 Trial. Reiss, Kim A., Mathew G. Angelos, E. Claire Dees, Yuan Yuan, Naoto T. Ueno, Paula R. Pohlmann, Melissa L. Johnson, Joseph Chao, Olga Shestova, Jonathan S. Serody, Maggie Schmierer, Madison Kremp, Michael Ball, Rehman Qureshi, Benjamin H. Schott, Poonam Sonawane, Sabrina Ceeraz DeLong, Melissa Christiano, Ramona F. Swaby, Sascha Abramson, Ken Locke, Debora Barton, Eugene Kennedy, Saar Gill, Daniel Cushing, Michael Klichinsky, Thomas Condamine, and Yara Abdou. Nature Medicine, February.

Investments in Hospitalist Research Could Deliver Financial Returns to Academic Medical Centers. Nuckols, Teryl K., and Andrew D. Auerbach. Journal of General Internal Medicine, February.

Senescence as a Molecular Target in Skin Aging and Disease. Thau, Henriette, Bastian P. Gerjol, Katharina Hahn, Rosalie Wolff von Gudenberg, Leonard Knoedler, Kenneth Stallcup, Maximilian Y. Emmert, Timo Buhl, Saranya P. Wyles, Tamar Tchkonia, Stefan G. Tullius, and Jasper Iske. Ageing Research Reviews, February, 102686.

Authors’ Reply to Letter-Ineffective Esophageal Motility and Gastroesophageal Reflux Disease. Kamboj, Amrit K., David A. Katzka, Marcelo F. Vela, Rena Yadlapati, and Karthik Ravi. Neurogastroenterology and Motility, February, e70001.

Global Burden of HBV-Related Liver Disease: Primary Liver Cancer Due to Chronic HBV Infection Increased in Over One-Third of Countries Globally From 2000 to 2021. Danpanichkul, Pojsakorn, Kwanjit Duangsonk, Vincent L. Chen, Preenapun Saokhieo, Disatorn Dejvajara, Banthoon Sukphutanan, Majd B. Aboona, Chawin Lopimpisuth, Yanfang Pang, Andrew F. Ibrahim, Michael B. Fallon, Daniel Q. Huang, Donghee Kim, Amit G. Singal, Ju Dong Yang, Bashar A. Aqel, Norah A. Terrault, and Karn Wijarnpreecha. Hepatology (Baltimore, Md.), February.

A1AT Dysregulation of Metabolically Stressed Hepatocytes by Kupffer Cells Drives MASH and Fibrosis. Park, Jeong-Su, Jin Lee, Feng Wang, Hwan Ma, Zixiong Zhou, Yong-Sun Lee, Kwangyeon Oh, Haram Lee, Guoyan Sui, Sangkyu Lee, Yoon Mee Yang, Jang-Won Lee, Yong-Ha Ji, Chun-Woong Park, Hwan-Soo Yoo, Bang-Yeon Hwang, Sang-Bae Han, Nan Song, Soohwan Oh, Bumseok Kim, Ekihiro Seki, Jin Tae Hong, and Yoon Seok Roh. Experimental & Molecular Medicine, February.

Minimal Residual Disease-Based End Point for Accelerated Assessment of Clinical Trials in Multiple Myeloma: A Pooled Analysis of Individual Patient Data From Multiple Randomized Trials. Shi, Qian, Bruno Paiva, Levi D. Pederson, Natalie Dimier, Ela Talpes, Thomas J. Prior, Alberto Orfao, Philippe Moreau, Pieter Sonneveld, Shaji K. Kumar, Jesse G. Dixon, Reshma Patel, Blake J. Bartlett, Jordan Schecter, Phillip McCarthy, Dirk Hose, Anja Seckinger, D’Agostino Mattia, Hartmut Goldschmidt, Stefania Oliva, Roger G. Owen, Kenneth C. Anderson, Jesús San-Miguel, Brian G. M. Durie, Nikhil Munshi, and International Independent Team for Endpoint Approval of Myeloma Minimal Residual Disease (i2TEAMM) Group. Journal of Clinical Oncology, February, JCO2402020.

State of the ART: Drug Screening Reveals Artesunate as a Promising Anti-Fibrosis Therapy. Qiao, Yujie, Jiurong Liang, and Dianhua Jiang. Journal of Respiratory Biology and Translational Medicine 2 (1): 10023.

Neurosurgery

Polymeric Nanoparticles With a Thermoresponsive Shell Loaded With Fluorescent Molecules Allow for Thermally Enhanced Fluorescence Imaging and Singlet Oxygen Generation. Chepurna, Oksana, Artem Yakovliev, Roman Ziniuk, Anna Grebinyk, Hao Xu, Olena A. Nikolaeva, Andrii I. Marynin, Liudmyla O. Vretik, Junle Qu, and Tymish Y. Ohulchanskyy. Nanoscale Advances, January.

Knowledge and Diagnostic Confidence of General Practitioners in Managing Idiopathic Intracranial Hypertension: A Nationwide Survey From the Northern Regions of Oman. AlHosni, Asma, Younis Al-Mufargi, Manar Al’ Abdulsalam, Al-Zahraa Al-Arafati, Abdullah Al Sawafi, Talal Alkhawaldi, and Tariq Al-Saadi. Journal of Clinical Neuroscience, 134 (February): 111080.

A Neuronal Code for Object Representation and Memory in the Human Amygdala and Hippocampus. Cao, Runnan, Peter Brunner, Puneeth N. Chakravarthula, Krista L. Wahlstrom, Cory Inman, Elliot H. Smith, Xin Li, Adam N. Mamelak, Nicholas J. Brandmeir, Ueli Rutishauser, Jon T. Willie, and Shuo Wang. Nature Communications 16 (1): 1510.

OBGYN

Phyllodes Tumor: A Rare Cause of False-Positive Pregnancy Test Result. Kracaw, Rachel A., Savannah Cotter, Ingmar N. Bastian, Yingao Zhang, Jessica Grenvik, and Kelly Blazek. Cureus 17 (1): e77071.

Pseudo-Meigs’ Syndrome in Mucinous Ovarian Carcinoma: A Case Report. Pipes, Grace, Bahaaeldin Youssef, Mariam Torossian, Kenneth H. Kim, and Margaret I. Liang. Gynecologic Oncology Reports 57 (February): 101678.

Orthopaedics

Validation of a Novel Landmark-Guided Intra-Articular Postero-Medial Surgeon-Administered Injection Technique. Piuzzi, Nicolas S., Andrew I. Spitzer, Jason Mussell, Ignacio Pasqualini, Stan Dysart, Jeffrey Gonzales, Michael A. Mont, Jess H. Lonner, and William Mihalko. Arthroplasty Today 31 (February): 101619.

30 Second Screening Test and Education Reduce Chronic Pain Incidence after Blood Donation: Large Prospective Observational Study from Japan. Hagiwara, Yusuke, Tatsuo Nakamura, Hiroko Shima, Yoshihiko Tani, Yoshimitsu Takahashi, Kentaro Sonoki, Keishichirou Moroi, and Ryu Yoshida. Medicine 104 (6): e41491.

ICRS-FIFA-Aspetar Consensus on the Management of Knee Cartilage Injuries in Football Players: Part 1 - Appropriateness of Surgery in Different Clinical Scenarios Using the RAND/UCLA Appropriateness Method. Kon, Elizaveta, Emmanuel Papakostas, Luca Andriolo, Andreas Serner, Andrew Massey, Peter Verdonk, Peter Angele, Claudia Arias, Camila Cohen Kaleka, Ramon Cugat, Pieter D’Hooghe, Francesco Della Villa, Cristiano Eirale, Christoph Erggelet, João Espregueira-Mendes, Christian Fink, Celeste Geertsema, Liesel Geertsema, Cassandra A. Lee, Bert Mandelbaum, Norimasa Nakamura, David A. Parker, Kristof Sas, Bertrand Sonnery-Cottet, Willem van der Merwe, Andy Williams, Stefano Zaffagnini, Bashir Ahmed Zikria, and Giuseppe Filardo. British Journal of Sports Medicine, February, bjsports-2024-108960.

Pathology and Laboratory Medicine

De Novo RUNX1-Driven Acute Myeloid Leukemia Requiring Integrative Genetics. Eno, Celeste C., Jeremy Lorber, Eric Vail, and Rhona Schreck. Cancer Genetics 292–293 (February): 69–72.

Comparison of Phenotypic and Genetic Traits of ESBL-Producing UPEC Strains Causing Recurrent or Single Episode UTI in Postmenopausal Women. Kalu, Michelle, Peter Jorth, and Annie Wong-Beringer. Annals of Clinical Microbiology and Antimicrobials 24 (1): 11.

Impact of Carbamylation and Anemia on the Association Between Glycated Albumin and Kidney Outcomes in Diabetic Kidney Disease. Tang, Mengyao, Anders Berg, Hui Zheng, and Sahir Kalim. Clinical Journal of the American Society of Nephrology: CJASN, February.

Radiation Oncology

Trends in Incidence, Metastasis, and Mortality From Thyroid Cancer in the USA From 1975 to 2019: A Population-Based Study of Age, Period, and Cohort Effects. Chen, Michelle M., Michael Luu, Wendy L. Sacks, Lisa Orloff, Lauren P. Wallner, Jon Mallen-St Clair, Susan C. Pitt, Allen S. Ho, and Zachary S. Zumsteg. The Lancet. Diabetes & Endocrinology, February, S2213-8587(24)00310-3.

Surgery

Colorectal cAncer and CrohN’s DIsease Study (CANDID): An International Multicentre Retrospective Audit. Garoufalia, Zoe, Sameh Hany Emile, Justin Dourado, Marylise Boutros, Richard Brady, Valerio Celentano, Justin Davies, Phillip R. Fleshner, Rachel Gefen, Stefan D. Holubar, Nir Horesh, Alaa El-Hussuna, Deborah Keller, Amy Lightner, Gianluca Pellino, Sherief Shawki, Spyros Siakavellas, Antonino Spinelli, Janindra Warusavitarne, and Steven D. Wexner. Colorectal Disease 27 (2): e70005.

Internalized Shame Experiences and Burnout in General Surgery Residents. Smith, Sophia M., Anna Kobzeva-Herzog, Patrick McGillen, Myriam Castagne-Charlotin, Joshua Davies, Sabrina E. Sanchez, Tracey Dechert, Tejal S. Brahmbhatt, and Sheina Theodore. Journal of Surgical Education 82 (4): 103447.

Health-Related Quality of Life and Hospital Costs of Finnish Melanoma Patients Participating in the Second Multicenter Selective Lymphadenectomy Trial (MSLT-II). Heino, Pia J., Jukka Pappinen, John F. Thompson, Micaela Hernberg, Tiina A. Jahkola, and Mark B. Faries. Acta Oncologica (Stockholm, Sweden) 64 (February): 247–56.

National Trends in Operative Approach to Esophagectomy: Utilization Rates, Outcomes, and Overall Survival. Weiser, Lucas, Claire Perez, Justin J. J. Watson, Qiudong Chen, Shruthi Nammalwar, Allen Razavi, Charles Fuller, Sevannah G. Soukiasian, Andrew R. Brownlee, and Harmik J. Soukiasian. Surgical Endoscopy, February.

Weight Stigma. Velazquez, Amanda. Endocrinology and Metabolism Clinics of North America 54 (1): 9–16.