Faculty Publications Aug. 1-8
A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators
This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Aug. 1-8. If you have a published paper from this period that does not appear on this list, please contact Sue Marone.
Biomedical Sciences
Heterozygous Knockout of Synaptotagmin13 Phenocopies ALS Features and TP53 Activation in Human Motor Neurons. Lehmann, Johannes, Amr Aly, Christina Steffke, Luca Fabbio, Valentin Mayer, Natalie Dikwella, Kareen Halablab, Francesco Roselli, Simone Seiffert, Tobias M. Boeckers, David Brenner, Edor Kabashi, Medhanie Mulaw, Ritchie Ho, and Alberto Catanese. Cell Death & Disease 15 (8): 560.
Acculturating to Multiculturalism: A New Dimension of Dietary Acculturation Among Asian American, Native Hawaiian, and Pacific Islander Women in the San Francisco Bay Area, USA. Tan, Judy Y., Alice Guan, Autumn E. Albers, Alison J. Canchola, Laura Allen, Salma Shariff-Marco, and Scarlett Lin Gomez. BMC Public Health 24 (1): 2128.
Nanoparticles Crossing Blood-Brain Barrier Need Specific Design for Normal, Neurodegenerative or Cancerous Brain Conditions. Ljubimova, Julia Y., Eggehard Holler, Keith L. Black, and Alexander V. Ljubimov. Nanomedicine (London, England), August, 1–4.
MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer. German, Beatriz, Sarah A. Alaiwi, Kun-Lin Ho, Jagpreet S. Nanda, Marcos A. S Fonseca, Deborah L. Burkhart, Anjali V. Sheahan, Hannah E. Bergom, Katherine L. Morel, Himisha Beltran, Justin H. Hwang, Matthew L. Freedman, Kate Lawrenson, and Leigh Ellis. Cancer Research Communications, August.
Cardiac Surgery
Comparative Effectiveness of Antiplatelet Therapies for Saphenous Venous Graft Occlusion and Cardiovascular Outcomes: A Network Meta-Analysis. Hasan, S. Umar, Alina Pervez, Mahrukh Afreen, Beenish Imam, Syed D. Shah, Arshad A. Shah, Sara A. Siddiqui, M. Mujeeb Zubair, and Asishana Osho. Minerva Cardiology and Angiology, August.
Cardiology
Predictors and Trends of New Permanent Pacemaker Implantation: A Subanalysis of the International Navitor IDE Study. Sultan, Ibrahim, Michael J. Reardon, Lars Søndergaard, Bassem Chehab, Dave Smith, Antony S. Walton, Stephen G. Worthley, Ganesh Manoharan, Gerald Yong, Hasan Jilaihawi, Federico Asch, Nicholas Bates, and Gregory P. Fontana. Structural Heart: The Journal of the Heart Team 8 (4): 100293.
Ten-Year Follow-up Cohort of the Everolimus Versus Azathioprine Multi-National Prospective Study Focusing on Intravascular Ultrasound Findings. Kim, In-Cheol, Randall C. Starling, Kiran Khush, Elizabeth Passano, James Mirocha, Peter Bernhardt, Babak Azarbal, Richard Cheng, Fardad Esmailian, Donna Mancini, Jignesh K. Patel, Takuma Sato, Shaida Varnous, and Jon A. Kobashigawa. The Journal of Heart and Lung Transplantation, July, S1053-2498(24)01779-0.
Cardiac Amyloidosis: Expanding Awareness to Optimize Diagnosis. Kittleson, Michelle M. JACC. Advances 3 (8): 101087.
COVID-19 in the Initiation and Progression of Atherosclerosis: Pathophysiology During and Beyond the Acute Phase. Chidambaram, Vignesh, Amudha Kumar, Murrium I. Sadaf, Emily Lu, Subhi J. Al’Aref, Tushar Tarun, Panagis Galiatsatos, Martha Gulati, Roger S. Blumenthal, Thorsten M. Leucker, Petros C. Karakousis, and Jawahar L. Mehta. JACC. Advances 3 (8): 101107.
Machine Learning Identification of Modifiable Predictors of Patient Outcomes After Transcatheter Aortic Valve Replacement. Russo, Mark J., Sammy Elmariah, Tsuyoshi Kaneko, David V. Daniels, Rajendra R. Makkar, Soumya G. Chikermane, Christin Thompson, Jose Benuzillo, Seth Clancy, Amber Pawlikowski, Skye Lawrence, and Jeff Luck. JACC. Advances 3 (8): 101116.
Patient Perceptions and Knowledge Surrounding Pregnancy After Heart Transplantation: A Multicenter Study. DeFilippis, Ersilia M., Elena M. Donald, Karlee Hoffman, Karen Flores Rosario, Richa Agarwal, Hilary Shapiro, Kimberly N. Hong, Kiran K. Khush, Lynn Punnoose, and Michelle M. Kittleson. Circulation. Heart Failure, August, e011741.
Indexed Aortic Valve Area Using Multimodality Imaging for Assessing the Severity of Bicuspid Aortic Stenosis. Yagi, Nobuichiro, Hiroko Hasegawa, Ken Kuwajima, Mana Ogawa, Takafumi Yamane, and Takahiro Shiota. International Journal of Cardiology, August, 132416.
Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States. Goel, Kashish, Raj Makkar, Amar Krishnaswamy, Samir Kapadia, Susheel Kodali, Ashish Shah, Colin Barker, Ke Xu, Abhijeet Dhoble, Pradeep Yadav, Charanjit S. Rihal, Amr E. Abbas, Mayra Guerrero, and Brian Whisenant. Circulation, August.
The Projected Impact of the Inflation Reduction Act’s Climate Provisions on Cardiovascular and Respiratory Outcomes. Kumar, Ashish, Sourbha Dani, Ajay Sharma, Sumanth Khadke, Martha Gulati, Sanjay Rajagopalan, Sadeer G. Al-Kindi, and Sarju Ganatra. American Journal of Preventive Cardiology 19 (September): 100707.
Computational Biomedicine
Co-Observation of Germline Pathogenic Variants in Breast Cancer Predisposition Genes: Results From Analysis of the BRIDGES Sequencing Dataset. Davidson, Aimee L., Kyriaki Michailidou, Michael T. Parsons, Cristina Fortuno, Manjeet K. Bolla, Qin Wang, Joe Dennis, Marc Naven, Mustapha Abubakar, Thomas U. Ahearn, M. Rosario Alonso, Irene L. Andrulis, Amanda B. Spurdle, et al. American Journal of Human Genetics, July, S0002-9297(24)00246-5.
A New Mixture Model With Cure Rate Applied to Breast Cancer Data. Gallardo, Diego I., Márcia Brandão, Jeremias Leão, Marcelo Bourguignon, and Vinicius Calsavara. Biometrical Journal. Biometrische Zeitschrift 66 (6): e202300257.
Medicine
OMERACT Systemic Lupus Erythematosus Domain Survey. Nielsen, Wils, Vibeke Strand, Lee Simon, Ellie Pinsker, Dennisse Bonilla, Eric Morand, Julian Thumboo, Martin Aringer, Marta Mosca, Ian Bruce, Ioannis Parodis, Alfred Kim, OMERACT SLE Working Group, et al. Seminars in Arthritis and Rheumatism 68 (July): 152520.
Development and Validation of a Noninvasive Model for the Detection of High-Risk Varices in Patients With Unresectable HCC. Parikh, Neehar D., Patricia Jones, Reena Salgia, Irun Bhan, Lauren T. Grinspan, Janice H. Jou, Kali Zhou, Prasun Jalal, Giorgio Roccaro, Amol S. Rangnekar, Jihane N. Benhammou, Anjana Pillai, Amit G. Singal, et al. Clinical Gastroenterology and Hepatology, July, S1542-3565(24)00678-5.
Irregular Z-Line: To Biopsy or Not to Biopsy? Kamboj, Amrit K., Srinivas Gaddam, Simon K. Lo, and Ali Rezaie. Digestive Diseases and Sciences, August.
Impact of Prior Inotuzumab Ozogamicin Treatment on Brexucabtagene Autoleucel Outcomes in Adults With B-Cell ALL. Aldoss, Ibrahim, Gregory W. Roloff, Rawan G. Faramand, Noam E. Kopmar, Chenyu Lin, Anjali S. Advani, Simone E. Dekker, Vishal K. Gupta, Timothy E. O’Connor, Nikeshan Jeyakumar, Ibrahim N. Muhsen, Yannis K. Valtis, Lori Muffly, et al. Blood Advances, August, bloodadvances.2024013747.
Real-World Clinical Effectiveness and Safety of Vedolizumab and Adalimumab in Biologic-Naive Patients With Crohn’s Disease: Results From the EVOLVE Study. Yarur, Andres J., Brian Bressler, Neil R. Brett, Marielle Bassel, Shashi Adsul, Pravin Kamble, and Gerassimos J. Mantzaris. Journal of Clinical Gastroenterology, August.
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth. Painter, Chelsea D., Nehru Viji Sankaranarayanan, Balaji Nagarajan, Thomas Mandel Clausen, Alan M. V. West, Nicollette J. Setiawan, Jeeyoung Park, Ryan N. Porell, Phillip L. Bartels, Daniel R. Sandoval, Gabriel J. Vasquez, John P. Chute, Kamil Godula, Craig W. Vander Kooi, Philip L. S. M. Gordts, Kevin D. Corbett, Christina M. Termini, Umesh R. Desai, and Jeffrey D. Esko. ACS Chemical Biology, August.
Low Dose Rifaximin Combined With N-Acetylcysteine Is Superior to Rifaximin Alone in a Rat Model of IBS-D: A Randomized Trial. Leite, Gabriela, Ali Rezaie, Walter Morales, Stacy Weitsman, Juliana de Freitas Germano, Gillian M. Barlow, Gonzalo Parodi, Maya L. Pimentel, Maria Jesus Villanueva-Millan, Maritza Sanchez, Sarah Ayyad, Ruchi Mathur, and Mark Pimentel. Scientific Reports 14 (1): 18140.
Intermittent Clearance of P21-Highly-Expressing Cells Extends Lifespan and Confers Sustained Benefits to Health and Physical Function. Wang, Binsheng, Lichao Wang, Nathan S. Gasek, Chia-Ling Kuo, Jia Nie, Taewan Kim, Pengyi Yan, Junyu Zhu, Blake L. Torrance, Yueying Zhou, Lisa C. Flores, Colton Allen, Allison M. Andrade, Chun Guo, Rachel L. Cohn, Evan R. Jellison, Jenna M. Bartley, George A. Kuchel, Sheng Li, Tamar Pirtskhalava, Tamar Tchkonia, Sumit Yadav, Laura Haynes, James L. Kirkland, Yuji Ikeno, and Ming Xu. Cell Metabolism 36 (8): 1795-1805.e6.
Overcome the Challenge for Intratumoral Injection of STING Agonist for Pancreatic Cancer by Systemic Administration. Li, Keyu, Junke Wang, Rui Zhang, Jiawei Zhou, Birginia Espinoza, Nan Niu, Jianxin Wang, Noelle Jurcak, Noah Rozich, Arsen Osipov, MacKenzie Henderson, Vanessa Funes, Melissa Lyman, Alex B. Blair, Brian Herbst, Mengni He, Jialong Yuan, Diego Trafton, Chunhui Yuan, Michael Wichroski, Xubao Liu, Juan Fu, and Lei Zheng. Journal of Hematology & Oncology 17 (1): 62.
Neurology
Relevance of Genetic Testing in the Gene-Targeted Trial Era: The Rostock Parkinson’s Disease Study. Westenberger, Ana, Volha Skrahina, Tatiana Usnich, Christian Beetz, Eva-Juliane Vollstedt, Björn-Hergen Laabs, Jefri J. Paul, Filipa Curado, Snezana Skobalj, Hanaa Gaber, Maria Olmedillas, Xenia Bogdanovic, Peter Bauer, et al. Brain: A Journal of Neurology 147 (8): 2652–67.
Neurosurgery
Assessment of Thrombectomy Versus Combined Thrombolysis and Thrombectomy in Patients With Acute Ischemic Stroke and Medium Vessel Occlusion. Dmytriw, Adam A., Sherief Ghozy, Hamza Adel Salim, Basel Musmar, James E. Siegler, Hassan Kobeissi, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Jeremy J. Heit, MAD-MT Consortium, et al. Radiology 312 (2): e233041.
Pituitary Apoplexy: A Re-Appraisal of Risk Factors and Best Management Strategies in the COVID-19 Era. Boyke, Andre E., Michelot Michel, and Adam N. Mamelak. Pituitary, August.
Orthopaedics
Effect of Glenoid Bone Loss and Shoulder Position on Axillary Nerve Anatomy During the Latarjet Procedure. Carbone, Andrew D., Daniel Kwak, Min-Shik Chung, Michelle H. McGarry, Andrew P. Nakla, Michael B. Banffy, and Thay Q. Lee. The American Journal of Sports Medicine 52 (9): 2340–47.
Preventing Anterior Cruciate Ligament (ACL) Injuries in High School Sports Participants: An Executive Summary of the Inaugural Meeting of the National ACL Injury Coalition. Robbins, Laura, Tom Farrey, Joseph Janosky, Vincent Minjares, Bert R. Mandelbaum, and Andrew Pearle. HSS Journal: The Musculoskeletal Journal of Hospital for Special Surgery 20 (3): 333–40.
Exercise Improves Load Bearing Bone Structural Properties in Female Secreted Protein Acidic and Rich in Cysteine (SPARC) Null Mice but Not in Males. Kaneda, Giselle, Dave Huang, Nathalie Pham, Alfonso R. Gonzalez, Wafa Tawackoli, Seunghwan Lee, Miyako Suzuki, Trevor J. Nelson, Juliane D. Glaeser, Magali Millecamps, Laura S. Stone, Dmitriy Sheyn, and Melodie F. Metzger. Journal of Orthopaedic Research, August.
In-Office Maximal Voluntary Ventilation Testing Demonstrates Pulmonary Improvement Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. Jalloh, Hulaimatu, Lindsay M. Andras, Greg Redding, Gabriela A. Villamor, Joshua Yang, and David L. Skaggs. Journal of Pediatric Orthopedics 44 (8): 497–501.
Pathology and Laboratory Medicine
Clinical Features Associated With Immune Checkpoint Inhibitor Nephritis: A Single-Center Clinical Case Series. Muddasani, Ramya, Neel Talwar, Isa Mambetsariev, Jeremy Fricke, Mercury Lin, Daniel Schmolze, Andrew Yue, Amna Rizvi, and Ravi Salgia. Cancer Immunology, Immunotherapy: CII 73 (10): 200.
Pediatrics
A Reversible Etiology of Progressive Motor Decline in a Previously Healthy Child. Eliav, Tal, Deandra Kuruppu, Pedro A. Sanchez-Lara, Katheryn Grand, Bahareh Schweiger, and Michelle Allen-Sharpley. Pediatrics, August, e2023064093.
Physical Medicine & Rehabilitation
Fast Facts and Concepts #488 Trauma-Informed Care Part 2: Essential Care Principles. Brown, Chelsea, Hedieh Matinrad, Arpit Arora, Megan E. Rau, Amy Sevick, and J. Janet Ho. Journal of Palliative Medicine, August.
Surgery
Interobserver Variability in the International Study Group for Pancreas Surgery (ISGPS)-Defined Complications After Pancreatoduodenectomy: An International Cross-Sectional Multicenter Study. Hendriks, Tessa E., Alberto Balduzzi, Susan van Dieren, J. Annelie Suurmeijer, Roberto Salvia, Thomas F. Stoop, Marco Del Chiaro, Sven D. Mieog, Mark Nielen, Sabino Zani, Daniel Nussbaum, Thilo Hackert, Jakob R. Izbicki, Ammar A. Javed, D. Brock Hewitt, Bas Groot Koerkamp, Roeland F. de Wilde, Yi Miao, Kuirong Jiang, Kohei Nakata, Masafumi Nakamura, Jin-Young Jang, Mirang Lee, Cristina R. Ferrone, Shailesh V. Shrikhande, Vikram A. Chaudhari, Olivier R. Busch, Ajith K. Siriwardena, Oliver Strobel, Jens Werner, Bert A. Bonsing, Giovanni Marchegiani, Marc G. Besselink, and International Study Group for Pancreatic Surgery (ISGPS). Annals of Surgery, August.
Relevance of Genetic Testing in the Gene-Targeted Trial Era: The Rostock Parkinson’s Disease Study. Westenberger, Ana, Volha Skrahina, Tatiana Usnich, Christian Beetz, Eva-Juliane Vollstedt, Björn-Hergen Laabs, Jefri J. Paul, Filipa Curado, Snezana Skobalj, Hanaa Gaber, Maria Olmedillas, Xenia Bogdanovic, Peter Bauer, et al. Brain: A Journal of Neurology 147 (8): 2652–67.
Enhancing Health Literacy: Evaluating the Readability of Patient Handouts Revised by ChatGPT’s Large Language Model. Swisher, Austin R., Arthur W. Wu, Gene C. Liu, Matthew K. Lee, Taylor R. Carle, and Dennis M. Tang. Otolaryngology--Head and Neck Surgery, August.