Faculty Publications Oct. 3-10

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Oct. 3-10. If you have a published paper from this period that does not appear on this list, please contact Sue Marone.

Cedars-Sinai in the News

Is it Better to Eat Before a Workout or After? | The New York Times
Martha Gulati, MD 

Strength Training May be the Key to Longevity. How to do it Safely as You Age | Los Angeles Times 
Martha Gulati, MD 

Can you Split Your Cholesterol-Lowering Pills in Half? | HealthCentral
Helen Leung, PharmD 

This is how Much Sleep you Really Need When You're Older | Verywell Health
Raj Dasgupta, MD 

Baxter Bringing Back Hurricane-hit IV Supply Facility in Stages | Reuters 

Los Infartos en los Jóvenes son Raros, Pero Están Aumentando. Estas son las Cuatro Posibles Causas | Yahoo! Vida y Estilo 
Noel Bairey Merz, MD 

‘Pars Fracture in the Young Athlete — When Should We Be Concerned?' | The Athlete Spine (YouTube)
David Skaggs, MD 

How Wave of Heart Attacks in Young People may be Being Fueled by COVID | Daily Mail
Susan Cheng, MD

Faculty Publications

Biomedical Sciences

Interscan Reproducibility of Computed Tomography Derived Coronary Plaque Volume Measurements. Iraqi, Nadia, Martin Bødtker Mortensen, Niels Peter Rønnow Sand, Martin Busk, Erik Lerkevang Grove, Damini Dey, Kamilla Bech Pedersen, Helle Kanstrup, Alexandra Uglebjerg Pedersen, Kristian Tækker Madsen, Erik Parner, Jesper Møller Jensen, and Bjarne Linde Nørgaard. Journal of Cardiovascular Computed Tomography, October, S1934-5925(24)00443-X.

Recruitment of Emergency Department Patients to a Prospective Observational Study. Shubeck, Claire, Hans Reyes Garay, Bret P. Nelson, Marcee Wilder, Aleksandra Degtyar, Megan Lukas, Lauren Gordon, George T. Loo, Bernice Coleman, Lynne D. Richardson, and Kimberly Souffront. International Journal of Emergency Medicine 17 (1): 142.

United Voices Group-Singing Intervention to Address Loneliness and Social Isolation Among Older People With HIV During the COVID-19 Pandemic: Intervention Adaption Study. Hill, Miranda, Meredith Greene, Julene K. Johnson, and Judy Y. Tan. JMIR Formative Research 8 (October): e60387.

AKT and EZH2 Inhibitors Kill TNBCs by Hijacking Mechanisms of Involution. Schade, Amy E., Naiara Perurena, Yoona Yang, Carrie L. Rodriguez, Anjana Krishnan, Alycia Gardner, Patrick Loi, Yilin Xu, Van T. M. Nguyen, G. M. Mastellone, Natalie F. Pilla, Marina Watanabe, Keiichi Ota, Rachel A. Davis, Kaia Mattioli, Dongxi Xiang, Jason J. Zoeller, Jia-Ren Lin, Stefania Morganti, Ana C. Garrido-Castro, Sara M. Tolaney, Zhe Li, David A. Barbie, Peter K. Sorger, Kristian Helin, Sandro Santagata, Simon R. V. Knott, and Karen Cichowski. Nature, October.

Cardiac Surgery

Development of a Novel Society of Thoracic Surgeons Aortic Surgery Mortality and Morbidity Risk Model. Desai, Nimesh D., Andrew Vekstein, Maria Grau-Sepulveda, Sean M. O’Brien, Hiroo Takayama, Edward P. Chen, G. Chad Hughes, Joseph E. Bavaria, David M. Shahian, Maral Ouzounian, Eric E. Roselli, Jeffrey P. Jacobs, Vinay Badhwar, Robert H. Habib, Vinod Thourani, Michael E. Bowdish, and Karen M. Kim. The Annals of Thoracic Surgery, October, S0003-4975(24)00833-6.

Cardiology

Exploring the Social Contributors to Biological Aging With Medical AI. Poterucha, Timothy J., Susan Cheng, and David Ouyang. JACC. Advances 3 (9): 100889.

Impact of Case and Control Selection on Training Artificial Intelligence Screening of Cardiac Amyloidosis. Vrudhula, Amey, Lily Stern, Paul C. Cheng, Piero Ricchiuto, Chathuri Daluwatte, Ronald Witteles, Jignesh Patel, and David Ouyang. JACC. Advances 3 (9): 100998.

Mortality After Multivessel Revascularization in Patients With Diabetes and Acute Coronary Syndromes. Godoy, Lucas C., Michael E. Farkouh, Peter C. Austin, Baiju R. Shah, Feng Qiu, Maneesh Sud, Jose C. Nicolau, Stephen E. Fremes, Rodolfo V. Rocha, Derrick Y. Tam, Karin H. Humphries, Patrick R. Lawler, Harindra C. Wijeysundera, Douglas S. Lee, Mario F. L. Gaudino, and Dennis T. Ko. JACC. Advances 3 (9): 101203.

Navigating the Gray Zone: AI Decision Support to Identify Aortic Stenosis Severity. Sarraju, Ashish, and David Ouyang. JACC. Advances 3 (9): 101178.

Permanent Pacing Reduces Blood Pressure in Older Patients With Drug-Resistant Hypertension: A New Pacing Paradigm? Nguyen, Bich Lien, Michael H. Burnam, Francesco Accardo, Angela Angione, Roberto Scacciavillani, Carly Pierson, and Eli S. Gang. The Journal of Innovations in Cardiac Rhythm Management 15 (9): 6014–21.

Whole-Genome Sequencing in 333,100 Individuals Reveals Rare Non-Coding Single Variant and Aggregate Associations With Height. Hawkes, Gareth, Robin N. Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Christine M. Albert, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, Eric Boerwinkle, Jennifer A. Brody, Michael N. Weedon, et al. Nature Communications 15 (1): 8549.

The Outcome of Restrictive Cardiac Allograft Physiology in Severe Coronary Allograft Vasculopathy. Tsuji, Masaki, Jignesh K. Patel, Michelle M. Kittleson, David H. Chang, Evan P. Kransdorf, Andriana P. Nikolova, Lily K. Stern, Nayana Bhatnagar, and Jon A. Kobashigawa. The Journal of Heart and Lung Transplantation, October, S1053-2498(24)01877-1.

Sudden Cardiac Death After Myocardial Infarction: Individual Participant Data From Pooled Cohorts. Peek, Niels, Gerhard Hindricks, Artur Akbarov, Jan G. P. Tijssen, David A. Jenkins, Zoher Kapacee, Le Mai Parkes, Rob J. van der Geest, Enrico Longato, Daniel Sprague, Youssef Taleb, Marcus Ong, Nikolaos Dagres, et al. European Heart Journal, October, ehae326.

Home-Time, Mortality, and Readmissions Among Patients Hospitalized With Heart Failure: A Baseline Prior to IMPLEMENT-HF. Tang, Amber B., Nicole Solomon, Karen Chiswell, Stephen J. Greene, Clyde W. Yancy, Mariell Jessup, Michelle Kittleson, Javed Butler, Nancy K. Sweitzer, Lee R. Goldberg, Jo-Ann Lindenfeld, Eldrin F. Lewis, Pamela N. Peterson, Sara Paul, Lynn Mallas Serdynski, Christine Rutan, Michelle Congdon, Sruthi Cherkur, and Gregg C. Fonarow. Circulation. Heart Failure, October, e011795.

Computational Biomedicine

Heparin Treatment Is Associated With a Delayed Diagnosis of Alzheimer’s Dementia in Electronic Health Records From Two Large United States Health Systems. Readhead, Benjamin, Eyal Klang, Undina Gisladottir, Maxence Vandromme, Li Li, Yakeel T. Quiroz, Joseph F. Arboleda-Velasquez, Joel T. Dudley, Nicholas P. Tatonetti, Benjamin S. Glicksberg, and Eric M. Reiman. Molecular Psychiatry, October.

Medicine

COPD Associated Pulmonary Hypertension: A Post Hoc Analysis of the PERFECT Study. Nathan, Steven D., Victoria Lacasse, Heidi Bell, Prakash Sista, Michael Di Marino, Todd Bull, Victor Tapson, and Aaron Waxman. Pulmonary Circulation 14 (4): e12430.

The Updated Registry of Fast Myocardial Perfusion Imaging With Next-Generation SPECT (REFINE SPECT 2.0). Miller, Robert J. H., Mark Lemley, Aakash Shanbhag, Giselle Ramirez, Joanna X. Liang, Valerie Builoff, Paul Kavanagh, Tali Sharir, M. Timothy Hauser, Terrence D. Ruddy, Mathews B. Fish, Timothy M. Bateman, Wanda Acampa, Andrew J. Einstein, Sharmila Dorbala, Marcelo F. Di Carli, Attila Feher, Edward J. Miller, Albert J. Sinusas, Julian Halcox, Monica Martins, Philipp A. Kaufmann, Damini Dey, Daniel S. Berman, and Piotr J. Slomka. Journal of Nuclear Medicine, October, jnumed.124.268292.

Inflammation and Immunity in Liver Neoplasms: Implications for Future Therapeutic Strategies. Kim, Jieun, and Ekihiro Seki. Molecular Cancer Therapeutics, October.

Vitamin D in Multiple Sclerosis: A Comprehensive Umbrella Review. Abbasi, Hamid, Sara Khoshdooz, Emad Alem, Farnush Bakhshimoghaddam, Saeid Doaei, and Mark O. Goodarzi. The Journal of Nutrition, October, S0022-3166(24)01071-X.

Mapping Epidermal and Dermal Cellular Senescence in Human Skin Aging. Yu, Grace T., Clarisse Ganier, David B. Allison, Tamara Tchkonia, Sundeep Khosla, James L. Kirkland, Magnus D. Lynch, and Saranya P. Wyles. Aging Cell, October, e14358.

The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors. Klonoff, David C., Guido Freckmann, Stefan Pleus, Boris P. Kovatchev, David Kerr, Chui Cindy Tse, Chengdong Li, Michael S. D. Agus, Kathleen Dungan, Barbora Voglová Hagerf, Jan S. Krouwer, Wei-An Andy Lee, Michael A. Kohn, et al. Journal of Diabetes Science and Technology, October, 19322968241275701.

Alcohol Consumption and Smoking History at Time of Diagnosis, and Risk of Colorectal Cancer Recurrence and Mortality: Results From the ColoCare Study. Loroña, Nicole C., Caroline Himbert, Jennifer Ose, Stacey A. Cohen, Ildiko Strehli, Cornelia M. Ulrich, Sofia Cobos, Esther Jean-Baptiste, Amanda M. Bloomer, Jane C. Figueiredo, Biljana Gigic, Sheetal Hardikar, Meghana Karchi, Matthew Mutch, Anita R. Peoples, Martin Schneider, David Shibata, Erin M. Siegel, Adetunji T. Toriola, Elizabeth H. Wood, and Christopher I. Li. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, October.

Anti-Plasma Cell Antibodies: A New Era of HLA Antibody Control in Solid Organ Transplantation? Chandran, Sindhu, and Flavio Vincenti. American Journal of Transplantation, October, S1600-6135(24)00633-6.

Fisetin as a Senotherapeutic Agent: Evidence and Perspectives for Age-Related Diseases. Tavenier, Juliette, Jan O. Nehlin, Morten Baltzer Houlind, Lene Juel Rasmussen, Tamara Tchkonia, James L. Kirkland, Ove Andersen, and Line Jee Hartmann Rasmussen. Mechanisms of Ageing and Development, October, 111995.

Senescent Cell Transplantation Into the Skin Induces Age-Related Peripheral Dysfunction and Cognitive Decline. Franco, Ana Catarina, Helene Martini, Stella Victorelli, Anthony B. Lagnado, Saranya P. Wyles, Jennifer L. Rowsey, Nicholas Pirius, Seung-Hwa Woo, Daniela G. Costa, Selim Chaib, Stefan G. Tullius, Tamar Tchkonia, James L. Kirkland, Sundeep Khosla, Diana Jurk, Claudia Cavadas, and João F. Passos. Aging Cell, October, e14340.

Meeting Report From the 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Philadelphia, PA, November 2023. Seedor, Rino S., Andrew E. Aplin, Corine Bertolotto, Richard D. Carvajal, Nigel Deacon, Katie Doble, Omid Hamid, Rizwan Haq, Miriam Kadosh, Shaheer Khan, Jacqueline Kraska, Jose Lutzky, Meredith McKean, Kamaneh Montazeri, Justin Moser, Michael Onken, Marlana Orloff, Joseph J. Sacco, Keiran Smalley, and Sara M. Selig. Pigment Cell & Melanoma Research, October.

Autoantibodies Targeting Nephrin in Podocytopathies. Berg, Anders H., and S. Ananth Karumanchi. The New England Journal of Medicine 391 (14): 1365–66.

Neurosurgery

Hyperspectral Retinal Imaging in Alzheimer’s Disease and Age-Related Macular Degeneration: A Review. Du, Xiaoxi, Jongchan Park, Ruixuan Zhao, R. Theodore Smith, Yosef Koronyo, Maya Koronyo-Hamaoui, and Liang Gao. Acta Neuropathologica Communications 12 (1): 157.

Jugular Venous Narrowing and Spontaneous Spinal Cerebrospinal Fluid Leaks: A Case-Control Study Exploring Association and Proposed Mechanism. Manupipatpong, Sasicha, Christopher T. Primiani, Kyle M. Fargen, Matthew R. Amans, Linda Leithe, Wouter I. Schievink, Mark G. Luciano, and Ferdinand K. Hui. Interventional Neuroradiology: Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences, October, 15910199241287417.

Theta Phase Precession Supports Memory Formation and Retrieval of Naturalistic Experience in Humans. Zheng, Jie, Mar Yebra, Andrea G. P. Schjetnan, Kramay Patel, Chaim N. Katz, Michael Kyzar, Clayton P. Mosher, Suneil K. Kalia, Jeffrey M. Chung, Chrystal M. Reed, Taufik A. Valiante, Adam N. Mamelak, Gabriel Kreiman, and Ueli Rutishauser. Nature Human Behaviour, October.

OBGYN

Methods for Multi-Omic Data Integration in Cancer Research. Hernández-Lemus, Enrique, and Soledad Ochoa. Frontiers in Genetics 15: 1425456.

Early-Career and Fellow Gynecologic Oncologists Perceive Underpreparedness for the Business of Medicine: A Society of Gynecologic Oncology Survey Study. Dholakia, Jhalak, Leslie R. Boyd, Rinki Agarwal, Haley Moss, Emily M. Ko, Emeline Aviki, and Margaret I. Liang. Gynecologic Oncology Reports 55 (October): 101501.

GD2 and GD3 Gangliosides as Prognostic Biomarkers in High Grade Serous Ovarian Cancer. Levin, Gabriel, Emad Matanes, Amber Yasmeen, Raanan Meyer, Melica Nourmoussavi Brodeur, Shannon Salvador, Susie Lau, H. Uri Saragovi, and Walter Gotlieb. Journal of Gynecology Obstetrics and Human Reproduction, October, 102860.

Orthopaedics

Prevalence and Clinical Impact of Coronal Malalignment Following Circumferential Minimally Invasive Surgery (CMIS) for Adult Spinal Deformity Correction. Tanasansomboon, Teerachat, Babak Khandehroo, Worawat Limthongkul, Wicharn Yingsakmongkol, and Neel Anand. Global Spine Journal, October, 21925682241290759.

Pathology and Laboratory Medicine

Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue. 2023. Huang, Rong Rong, Jenna M. Giafaglione, Takao Hashimoto, Liying Zhang, Weibo Yu, Jianyu Rao, Joshua W. Russo, Steven P. Balk, Nicholas G. Nickols, Mathew B. Rettig, Andrew Goldstein, and Huihui Ye. Journal of Clinical and Translational Pathology 3 (2): 49–58.

An Initial Game-Theoretic Assessment of Enhanced Tissue Preparation and Imaging Protocols for Improved Deep Learning Inference of Spatial Transcriptomics From Tissue Morphology. Fatemi, Michael Y., Yunrui Lu, Alos B. Diallo, Gokul Srinivasan, Zarif L. Azher, Brock C. Christensen, Lucas A. Salas, Gregory J. Tsongalis, Scott M. Palisoul, Laurent Perreard, Fred W. Kolling, Louis J. Vaickus, and Joshua J. Levy. Briefings in Bioinformatics 25 (6): bbae476.

Pediatrics

Phase II Trial of Gemcitabine and Nab-Paclitaxel for Recurrent Osteosarcoma With Serial Monitoring Using Liquid Biopsy: A Report From the National Pediatric Cancer Foundation. Dhir, Aditi, Masanori Hayashi, Avery Bodlak, Javier Oesterheld, David M. Loeb, Leo Mascarenhas, Michael S. Isakoff, Eric S. Sandler, Scott C. Borinstein, Matteo Trucco, Joanne P. Lagmay, Bhuvana A. Setty, Christine A. Pratilas, Emi Caywood, Jonathan Metts, Hong Yin, Brooke Fridley, Jun Yin, Jose Laborde, Damon R. Reed, Daniel L. Adams, and Lars M. Wagner. Clinical Cancer Research, October.

Radiation Oncology

Radiation Target Nomenclature for Lymphoma Trials: Consensus Recommendations From the National Clinical Trials Network Groups. Saifi, Omran, Chelsea C. Pinnix, Leslie K. Ballas, Chris R. Kelsey, Sarah A. Milgrom, Stephanie A. Terezakis, Nicholas B. Figura, Rahul R. Parikh, John C. Grecula, Stella Flampouri, Chul S. Ha, Andrea C. Lo, John P. Plastaras, David C. Hodgson, and Bradford S. Hoppe. The Lancet. Haematology, September, S2352-3026(24)00276-X.

Challenges and Opportunities for Early Phase Clinical Trials of Novel Drug-Radiotherapy Combinations: Recommendations From NRG Oncology, the American Society for Radiation Oncology (ASTRO), the American College of Radiology (ACR), the Sarah Cannon Research Institute, and the American College of Radiation Oncology (ACRO). Zumsteg, Zachary S., Siddharth Sheth, Salma K. Jabbour, Krishnan R. Patel, Randall J. Kimple, Terence M. Williams, Meng Xu-Welliver, Pedro A. Torres-Saavedra, Arta M. Monjazeb, Jyoti Mayadev, Steven E. Finkelstein, John M. Buatti, Sandip P. Patel, and Steven H. Lin. The Lancet. Oncology 25 (10): e489–500.

Surgery

2024 Eerie ENT Cases Course Co-Directors’ Introduction. Barbu, Anca M., and Martin L. Hopp. Ear, Nose, & Throat Journal 103 (2_suppl): 6S.

Prophylactic Carpal Tunnel Release During Volar Plating of Distal Radius Fractures: A Review. Parikh, Harin B., Violette C. Simon, and Stuart H. Kuschner. Journal of Hand Surgery Global Online 6 (5): 631–35.

Scaphocapitate Arthrodesis for Wrist Deformities: A Systematic Review. Deptula, Peter, Meghan McCullough, Theodore Brown, Dylan Singh, Stuart Kuschner, and David Kulber. Plastic and Reconstructive Surgery. Global Open 12 (10): e6205.

Base-Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma. Meng, Fan, Tiane Li, Anup K. Singh, Yingying Wang, Marc Attiyeh, Fatemeh Kohram, Qianhua Feng, Yun R. Li, Binghui Shen, Terence Williams, Yilun Liu, and Mustafa Raoof. Cell Reports 43 (10): 114820.

Clinical Outcomes of Children With COVID-19 and Appendicitis: A Propensity Score Matched Analysis. Odegard, Marjorie N., Olivia A. Keane, Shadassa A. Ourshalimian, Christopher J. Russell, William G. Lee, Makayla L. O’Guinn, Laura M. C. Houshmand, and Lorraine I. Kelley-Quon. Pediatric Surgery International 40 (1): 266.

The Evolutionary Forest of Pancreatic Cancer. Mullen, Katelyn M., Jungeui Hong, Marc A. Attiyeh, Akimasa Hayashi, Hitomi Sakamoto, Zachary A. Kohutek, Caitlin A. McIntyre, Haochen Zhang, Alvin P. Makohon-Moore, Amanda Zucker, Laura D. Wood, Matthew A. Myers, Brian J. Arnold, Simone Zaccaria, Joanne F. Chou, Marinela Capanu, Nicholas D. Socci, Benjamin J. Raphael, and Christine A. Iacobuzio-Donahue. Cancer Discovery, October.