Faculty Publications Feb. 13-20

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 13-20. If you have a published paper from this period that does not appear on this list, please contact Sue Marone.

Cedars-Sinai in the News

Heart Failure Deaths Are Increasing. New Treatments Could Help. | The New York Times
Michelle Kittleson, MD

If You Notice Your Knees Making This Sound, See a Doctor ASAP | Parade
Clint Soppe, MD 

Flu and Stomach Bugs Are Spreading Fast—Are You Prepared? | HealthDay
Priya Soni, MD 

People With Tricuspid Valve Disease Have new Treatment Options | Diagnostic and Interventional Cardiology
Raj Makkar, MD 

Thyroid Cancer Rates Remain ‘Frozen’ Amid Overdiagnosis | Medscape
Zachary Zumsteg, MD 

Why Is Weight Loss Sometimes so Difficult? Blame Your Hormones | Everyday Health
Adrienne Youdim, MD 

These Supplements Can get Rid of ‘Zombie Cells’ That Speed up Aging – But Doctors Have a Warning | New York Post
James Kirkland, MD, PhD 

Cedars-Sinai / Estudio Revela Prometedor Tratamiento Para Prevenir la Insuficiencia Cardíaca Post-Infarto en Ratones | Enlace Judío
Jennifer Van Eyk, PhD; Eduardo Marbán, MD, PhD

Faculty Publications

Biomedical Sciences

Neurotrophic Factors for Parkinson’s Disease: Current Status, Progress, and Remaining Questions. Conclusions From a 2023 Workshop. Barker, Roger A., Mart Saarma, Clive N. Svendsen, Catherine Morgan, Alan Whone, Massimo S. Fiandaca, Matthias Luz, Krystof S. Bankiewicz, Brian Fiske, Lyndsey Isaacs, Arthur Roach, Thomas Phipps, Jeffrey H. Kordower, Emma L. Lane, Henri J. Huttunen, Aideen Sullivan, Gerard O’Keeffe, Valeria Yartseva, and Howard Federoff. Journal of Parkinson’s Disease 14 (8): 1659–76.

Retrospectively Quantified T2 Improves Detection of Clinically Significant Peripheral Zone Prostate Cancer. Sun, Haoran, Lixia Wang, Timothy Daskivich, Shihan Qiu, Hsu-Lei Lee, Chang Gao, Rola Saouaf, Eric Lo, Alessandro D’Agnolo, Hyung Kim, Debiao Li, and Yibin Xie. Cancers 17 (3): 381.

Cardiac Surgery

Characteristics and Outcomes of Patients With Cardiogenic Shock and Clinically Significant Valvular Heart Disease: From the Critical Care Cardiology Trials Network. Carnicelli, Anthony P., P. Elliott Miller, David D. Berg, Nijat Aliyev, Carlos L. Alviar, Erin A. Bohula, Sunit-Preet Chaudhry, Meshe Chonde, Christine Chow, Howard A. Cooper, Lori B. Daniels, Christopher B. Fordyce, Shahab Ghafghazi, Michael J. Goldfarb, Kari L. Gorder, Madeleine M. Hamilton, Ryan R. Keane, Michael C. Kontos, Jonathan J. Kusner, Evan Leibner, Daniel B. Loriaux, Venu Menon, Raunak M. Nair, L. Kristin Newby, Mary-Tiffany Oduah, Michael G. Palazzolo, Harsh Patolia, Jacob B. Pierce, Matthew J. Pierce, Brian J. Potter, Alastair Proudfoot, Robert O. Roswell, Gregory Schnell, Jeffrey Shaw, Kiran Sidhu, Shashank S. Sinha, Anubodh S. Varshney, Jason N. Katz, Sean van Diepen, and David A. Morrow. Journal of Cardiac Failure, February, S1071-9164(25)00058-2.

Cardiology

Underpinnings of Heart Failure With Preserved Ejection Fraction in Women - From Prevention to Improving Function. A Co-Publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure. Radakrishnan, Ankitha, Saloni Agrawal, Nausheen Singh, Anna Barbieri, Leslee J. Shaw, Martha Gulati, and Anuradha Lala. Journal of Cardiac Failure, February, S1071-9164(25)00037-5.

Comparative Predictors of Mortality Risk in Contemporary Patients Referred for Stress Myocardial Perfusion Imaging. Rozanski, Alan, Heidi Gransar, Robert J. H. Miller, Donghee Han, Sean W. Hayes, John D. Friedman, Louise Thomson, Carl J. Lavie, and Daniel S. Berman. Mayo Clinic Proceedings, February, S0025-6196(24)00481-6.

Extensive Pericardial Metastasis of Angiosarcoma: Diagnostic Challenge in a Young Case With Effusive Constrictive Pericarditis. Takahashi, Tatsunori, Debbie Lin Teodorescu, Wyleen Kniola, Daniel Luthringer, and Siddharth Singh. The American Journal of Cardiology, February, S0002-9149(25)00083-9.

Will the Real High Risk Heart Transplant Recipients Please Stand Up? Jain, Rashmi, and Evan P. Kransdorf. The Journal of Heart and Lung Transplantation, February, S1053-2498(25)01663-8.

Age-Related Outcomes of Valve-in-Valve Transcatheter Aortic Valve Replacement for Structural Valve Deterioration. Nagasaka, Takashi, Vivek Patel, Kazuki Suruga, Alon Shechter, Ofir Koren, Tarun Chakravarty, Wen Cheng, Hideki Ishii, Hasan Jilaihawi, Mamoo Nakamura, and Raj R. Makkar. Journal of the American Heart Association 14 (4): e037168.

Hypertension in Pregnancy and Postpartum: Current Standards and Opportunities to Improve Care. Countouris, Malamo, Zainab Mahmoud, Jordana B. Cohen, Daniela Crousillat, Afshan B. Hameed, Colleen M. Harrington, Alisse Hauspurg, Michael C. Honigberg, Jennifer Lewey, Kathryn Lindley, Megan M. McLaughlin, Neha Sachdev, Amy Sarma, Kayle Shapero, Rachel Sinkey, Alan Tita, Kristen E. Wong, Eugene Yang, Leslie Cho, and Natalie A. Bello. Circulation 151 (7): 490–507.

Computational Biomedicine

Computer Adaptive Testing Strategies for the Edinburgh Postnatal Depression Scale (EPDS). Wong, Emily F., Eynav E. Accortt, Seung W. Choi, and Tiffani J. Bright. Archives of Women’s Mental Health, February.

AI as an Accelerator for Defining New Problems That Transcends Boundaries. Obafemi-Ajayi, Tayo, Steven F. Jennings, Yu Zhang, Kara Li Liu, Joan Peckham, and Jason H. Moore. BioData Mining 18 (1): 17.

Lessons Learned From a Candidate Gene Study Investigating Aromatase Inhibitor Treatment Outcome in Breast Cancer. Hoppe, Reiner, Stefan Winter, Wing-Yee Lo, Kyriaki Michailidou, Manjeet K. Bolla, Renske Keeman, Qin Wang, Joe Dennis, Michael Lush, Krishna R. Kalari, Matthew P. Goetz, Liewei Wang, Hiltrud Brauch, et al. NPJ Breast Cancer 11 (1): 18.

Medicine

Chemopreventive Strategies for Sporadic Colorectal Cancer: A Narrative Review. Monson, Savanna, Pin-Jung Chen, Alexandra Gangi, Kevin Waters, Sandrine Billet, Andrew Hendifar, Shelly Lu, Jason A. Zell, and Jun Gong. Translational Gastroenterology and Hepatology 10: 11.

Patient Perspectives on Acromegaly Disease Burden: Insights From a Community Meeting. Shah, Shruti N., Kevin C. J. Yuen, Vivien Bonert, Wenyu Huang, Jill Sisco, Chrystal Palaty, Kristen Dancel-Manning, and Nidhi Agrawal. Frontiers in Endocrinology 16: 1516131.

Predictive Factors for Early Mortality After EUS-Guided Gastroenterostomy in Malignant Gastric Outlet Obstruction. Lee, Hyuk, Kenneth Hyunsoo Park, Ulysses Rosas, Mohamad Othman El Helou, Jae Min Lee, Liliana Bancila, Laith H. Jamil, Quin Liu, Rabindra R. Watson, Srinivas Gaddam, and Simon K. Lo. Endoscopy International Open 13: a24749802.

A Phase IB Trial of Selinexor in Combination With Immune Checkpoint Blockade in Patients With Advanced Renal Cell Carcinoma. Alhalabi, Omar, Mohamed A. Gouda, Denái R. Milton, Hassan Ahmed Momin, Bulent Yilmaz, Bettzy Stephen, Chinenye Lynette Ejezie, Justin Tyler Moyers, Serdar A. Gurses, Jeffrey How, Siqing Fu, Jordi Rodon, David S. Hong, Sarina A. Piha-Paul, Vivek Subbiah, Ecaterina Elena Dumbrava, Daniel D. Karp, Filip Janku, Funda Meric-Bernstam, Nizar M. Tannir, and Aung Naing. Cancer Medicine 14 (4): e70280.

S-Adenosylmethionine: A Multifaceted Regulator in Cancer Pathogenesis and Therapy. Fernández-Ramos, David, Fernando Lopitz-Otsoa, Shelly C. Lu, and José M. Mato. Cancers 17 (3): 535.

Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends from the Global Burden of Disease Study 2021. Danpanichkul, Pojsakorn, Kanokphong Suparan, Thanida Auttapracha, Primrose Tothanarungroj, Siwanart Kongarin, Krittameth Rakwong, Darren Jun Hao Tan, Banthoon Sukphutanan, Mark D. Muthiah, Daniel Tung, Junpeng Luo, Asahiro Morishita, En Ying Tan, Hirokazu Takahashi, Omar Y. Mousa, Rashid N. Lui, Mazen Noureddin, Donghee Kim, Denise M. Harnois, Ju Dong Yang, Lewis R. Roberts, Michael B. Wallace, and Karn Wijarnpreecha. Mayo Clinic Proceedings, February, S0025-6196(24)00616-5.

Selective Removal of Proteins and Microvesicles Ex Vivo From Blood of Pancreatic Cancer Patients Using Bioengineered Adsorption Filters. Waldron, Richard T., Ruoxiang Wang, Stephanie N. Shishido, Aurelia Lugea, Ahmed G. Ibrahim, Jeremy Mason, Matthew Ayres, Sarah J. Parker, Jennifer E. Van Eyk, Simon K. Lo, Peter Kuhn, and Stephen J. Pandol. Cancer Letters 614 (February): 217546.

Metastatic Tumor Growth in Steatotic Liver Is Promoted by HAS2-Mediated Fibrotic Tumor Microenvironment. Yang, Yoon Mee, Jieun Kim, Zhijun Wang, Jina Kim, So Yeon Kim, Gyu Jeong Cho, Jee Hyung Lee, Sun Myoung Kim, Takashi Tsuchiya, Michitaka Matsuda, Vijay Pandyarajan, Stephen J. Pandol, Michael S. Lewis, Alexandra Gangi, Paul W. Noble, Dianhua Jiang, Akil Merchant, Edwin M. Posadas, Neil A. Bhowmick, Shelly C. Lu, Sungyong You, Alexander M. Xu, and Ekihiro Seki. The Journal of Clinical Investigation, February, e180802.

A Mediterranean Diet for Crohn’s Disease: Embracing Colorful Diversity to Improve the Microbiome. Abreu, Maria T., Suzanne Devkota, and Kelly Issokson. Gastroenterology, February, S0016-5085(25)00366-X.

Deep Sequencing of Crohn’s Disease Lamina Propria Phagocytes Identifies Pathobionts and Correlates With Pro-Inflammatory Gene Expression. Jacobsen, Gillian E., Eddy E. Gonzalez, Payton Mendygral, Katerina M. Faust, Hajar Hazime, Irina Fernandez, Ana M. Santander, Maria A. Quintero, Chunsu Jiang, Oriana M. Damas, Amar R. Deshpande, David H. Kerman, Siobhan Proksell, Morgan Sendszichew Shane, Daniel A. Sussman, Bassel Ghaddar, Trevor Cickovsk, and Maria T. Abreu. Inflammatory Bowel Diseases, February, izae316.

DNA Damage Repair Gene Alterations Influence the Tumor Immune Microenvironment in Advanced Non-Small Cell Lung Cancer. Sankar, Kamya, Jacob Mercer, Ellen B. Jaeger, Jen Godden, Edward Williams, Michael A. Thompson, Shetal A. Patel, Jane C. Figueiredo, Frank Weinberg, and Karen L. Reckamp. Lung Cancer (Amsterdam, Netherlands) 201 (February): 108444.

Vitamin E (300 Mg) in the Treatment of MASH: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study. Song, Yu, Wenjing Ni, Minghua Zheng, Huiping Sheng, Jing Wang, Shilong Xie, YongFeng Yang, Xiaoling Chi, Jinjun Chen, Fangping He, Xiaotang Fan, Yuqiang Mi, Jing Zhang, Bingyuan Wang, Lang Bai, Wen Xie, Bihui Zhong, Yee Hui Yeo, Fajuan Rui, Shufei Zang, Jie Li, Junping Shi, and Chinese NAFLD Clinical Research Network (CNAFLD CRN). Cell Reports. Medicine 6 (2): 101939.

Roadmap for Alleviating the Manifestations of Ageing in the Cardiovascular System. Liberale, Luca, Simon Tual-Chalot, Simon Sedej, Stefano Ministrini, Georgios Georgiopoulos, Myriam Grunewald, Magnus Bäck, Marie-Luce Bochaton-Piallat, Reinier A. Boon, Gustavo Campos Ramos, Menno P. J. de Winther, Konstantinos Drosatos, Konstantinos Stellos, et al. Nature Reviews. Cardiology, February.

The MLL3/GRHL2 Complex Regulates Malignant Transformation and Anti-Tumor Immunity in Squamous Cancer. Nam, Chehyun, Guowei Huang, Yueyuan Zheng, Hua Zhao, Yuhao Pan, Boyan Hu, Talia Wenger, Hieu T. Van, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, Kai Ge, Yali Dou, Uttam K. Sinha, Young Min Park, and De-Chen Lin. The Journal of Experimental Medicine 222 (4): e20240758.

Neurology

Disease Progression in Charcot-Marie-Tooth Disease Type 4B (CMT4B) Associated With Mutations in Myotubularin-Related Proteins 2 and 13. Bertini, Alessandro, Mary M. Reilly, Chiara Pisciotta, Stefano C. Previtali, Yesim Parman, Esra Battaloglu, Matilde Laurà, Julian Blake, Sabrina Sacconi, Shahram Attarian, Tanya Stojkovic, Mounia Bellatache, Sonia Nouioua, Meriem Tazir, Arman Cakar, Antonio Gambardella, Paola Valentino, Richard A. Lewis, Rita Horvath, Alberto A. Zambon, Mario Sabatelli, Marco Luigetti, Stefano Tozza, Fiore Manganelli, David N. Herrmann, Steven S. Scherer, Nicole Kressin, Kailee Ward, Alessandra Bolino, Michael E. Shy, Davide Pareyson, CMT4B Study Group, and Inherited Neuropathy Consortium. European Journal of Neurology 32 (2): e70084.

Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. Paganoni, Sabrina, Christina N. Fournier, Eric A. Macklin, Lori B. Chibnik, Melanie Quintana, Benjamin R. Saville, Michelle A. Detry, Matteo Vestrucci, Joe Marion, Anna McGlothlin, Senda Ajroud-Driss, Marianne Chase, HEALEY ALS Platform Trial Study Group, et al. JAMA Network Open 8 (2): e2459058.

Neurosurgery

Nano-Polymers as Cas9 Inhibitors. Chepurna, Oksana, Avradip Chatterjee, Yuanqing Li, Hong Ding, Ramachandran Murali, Keith L. Black, and Tao Sun. Polymers 17 (3): 417.

Retinal Ganglion Cell Vulnerability to Pathogenic Tau in Alzheimer’s Disease. Davis, Miyah R., Edward Robinson, Yosef Koronyo, Elena Salobrar-Garcia, Altan Rentsendorj, Bhakta P. Gaire, Nazanin Mirzaei, Rakez Kayed, Alfredo A. Sadun, Alexander V. Ljubimov, Lon S. Schneider, Debra Hawes, Keith L. Black, Dieu-Trang Fuchs, and Maya Koronyo-Hamaoui. Acta Neuropathologica Communications 13 (1): 31.

OBGYN

The Impact of Surgeon Specialty on Surgical Outcomes Following Colorectal Resection for Endometriosis. Nasseri, Yosef, Rachel Ma, Negin Fani, Kristina La, Paola Solis-Pazmino, Vincent Xu, Matthew T. Siedhoff, Kelly N. Wright, Rebecca Schneyer, Kacey M. Hamilton, Moshe Barnajian, and Raanan Meyer. Colorectal Disease, 27 (2): e70028.

Orthopaedics

Investigating the Relationship Between Subacromial Balloon Spacer Study Outcomes and Study Funding. Feingold, Cailan L., Eric H. Lin, Ajith K. Subhash, Joshua M. Yazditabar, Avinesh Agarwalla, and Joseph N. Liu. Journal of Shoulder and Elbow Surgery, February, S1058-2746(25)00143-0.

Trends in Depression and Anxiety Prevalence by Cancer Status Among US Adults: Analyses of the 2019-2022 National Health Interview Survey. Kim, Ian, Michelle Lee, Cynthia M. Begay, Jonathan Lee, and Jennifer Unger. BMJ Open 15 (2): e090157.

Vitality of Global Alignment Following Adult Spinal Deformity Surgery to Long-Term Improvement of Patient-Reported Outcomes Regardless of Regional Alignment. Mikhail, Christopher, Sarthak Mohanty, Fthimnir M. Hassan, Christopher S. Lai, Stephen R. Stephan, Andrew Platt, Nathan J. Lee, Joseph M. Lombardi, Zeeshan M. Sardar, Ronald A. Lehman, and Lawrence G. Lenke. Journal of Neurosurgery. Spine, February, 1–11.

Editor’s Introduction: State of the Art in Minimally Invasive Spine Surgery-Detailed Techniques and Pearls of Wisdom from the Masters. Anand, Neel. International Journal of Spine Surgery, February, 8710.

Pathology and Laboratory Medicine

Fourth Cytopathology Monograph and Atlas Series Book Titled ‘Cytopathology of Urine (& The Paris System)’ as Extension of Open Access Charter of Cytopathology Foundation Inc. Shidham, Vinod B., Shikha Bose, Zubair Baloch, and Lester J. Layfield. CytoJournal 22: 4.

Spatially Resolved, Multi-Region Proteomics for Prediction of Immunotherapy Outcome in Deficient Mismatch Repair Metastatic Colorectal Cancer. Saberzadeh-Ardestani, Bahar, Zhenglong Liu, Mariam I. Stein, Will A. Sherman, Christy E. Trussoni, Charles W. Abbott, Dongyao Yan, Skyler Smith, Kandavel Shanmugam, Rondell P. Graham, Alos Diallo, Joshua J. Levy, Tamas Ordog, and Frank A. Sinicrope. Clinical Cancer Research, February.

Radiation Oncology

Novel Pre-Spatial Data Fusion Deep Learning Approach for Multimodal Volumetric Outcome Prediction Models in Radiotherapy. Asbach, John C., Anurag K. Singh, Austin J. Iovoli, Mark Farrugia, and Anh H. Le. Medical Physics, February.

Early Cardio-Oncology Intervention in Thoracic Radiotherapy: Prospective Single-Arm Pilot Study. Zhang, Samuel C., Jordan O. Gasho, Celeste Eno, Katrina D. Silos, Felicity Pendergast, Wenjuan Zhang, Eric Vail, Mitchell Kamrava, Behrooz Hakimian, Amin Mirhadi, Raymond H. Mak, Andriana P. Nikolova, and Katelyn M. Atkins. Communications Medicine 5 (1): 43.

Surgery

Objectifying Aesthetic Outcomes Following Face Transplantation - the AI Research Metrics Model (CAARISMA ® ARMM). Knoedler, Leonard, Cosima C. Hoch, Samuel Knoedler, Felix J. Klimitz, Thomas Schaschinger, Tobias Niederegger, Max Heiland, Steffen Koerdt, Rainer Pooth, Martin Kauke-Navarro, and Alexandre G. Lellouch. Journal of Stomatology, Oral and Maxillofacial Surgery 126 (6): 102277.

Exploring Completion Rates of the SNOT-22 Questionnaire. Amin, Luv, John Davis, Mishek Thapa, Syeda L. Khalil, Arthur W. Wu, Thomas S. Higgins, and Dennis M. Tang. The Annals of Otology, Rhinology, and Laryngology, February, 34894251320303.

Urology

Do Trial Benefits Predict Real-World Gains in Metastatic Castration Resistant Prostate Cancer. Axeen, Sarah, Alice J. Chen, Darius N. Lakdawalla, Neal Masia, Alexander Niyazov, Bhakti Arondekar, and Stephen J. Freedland. JNCI Cancer Spectrum, February, pkaf018.

PSA Density to Select MRI Targeted Versus Combined Biopsy for Prostate Cancer Diagnosis: A Secondary Analysis of the Trio Study. Ahdoot, Michael, Aurash Naser-Tavakolian, John R. Heard, Cheyenne Williams, Michael Daneshvar, Patrick Gomella, Samhita Mallavarapu, Minhaj Siddiqui, Michael Nazmifar, Joanna Shih, Baris Turkbey, Bradford Wood, and Peter Pinto. The Journal of Urology, February, 101097JU0000000000004480.

Using Major Histocompatibility Complex (MHC) II Expression to Predict Antitumor Response to CD4 + Lymphocyte Depletion. Wang, Yanping, Minhyung Kim, Shengchen Su, Lahiruni Halwatura, Sungyong You, and Hyung L. Kim. Scientific Reports 15 (1): 5469.