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2023
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Faculty Publications Dec. 14-21

A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Dec. 14-21. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to the next collection publishing on Friday, Jan. 5.

Anesthesiology

Echocardiographic Outcomes With Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in Prohibitive Surgical Risk Patients. Marcoff, Leo, Konstantinos Koulogiannis, Lilian Aldaia, Anuj Mediratta, Scott M. Chadderdon, Moody M. Makar, Tobias Friedrich Ruf, Theresa Gößler, Jonathan G. Zaroff, Gordon K. Leung, Ivy A. Ku, Michael Nabauer, CLASP IID Pivotal Trial Investigators, et al. JACC. Cardiovascular Imaging, December, S1936-878X(23)00443-6.

Impact of Adverse Childhood Experiences on Health-Related Outcomes in Adults: Potential Implications for Perioperative Anesthetic Management. Elvir-Lazo, Ofelia Loani, Melanie Yoshihara, Paul F. White, and Roya Yumul. Anesthesia and Analgesia 138 (1): 210–15.

Biomedical Sciences 

Effects of Vitamin K2 and D Supplementation on Coronary Artery Disease in Men. Hasific, Selma, Kristian A. Oevrehus, Jes S. Lindholt, Anna Mejldal, Damini Dey, Jordi S. Dahl, Niels Erik Frandsen, Søren Auscher, Jess Lambrechtsen, Susanne Hosbond, Dilek Alan, Grazina Urbonaviciene, Søren Becker, Lars M. Rasmussen, and Axel P. Diederichsen. JACC: Advances 2 (9): 100643.

Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course. Catalán-Serra, Ignacio, Silje Thorsvik, Vidar Beisvag, Torunn Bruland, David Underhill, Arne Kristian Sandvik, and Atle van Beelen Granlund. Inflammatory Bowel Diseases, December, izad289.

Cardiac Surgery

Coronary Artery Bypass Surgery vs. Percutaneous Interventions for Women With Multivessel Coronary Artery Disease. Hannan, Edward L., Yifeng Wu, Lamia Harik, Jacqueline Tamis-Holland, Alice K. Jacobs, Joanna Chikwe, Kimberly S. Cozzens, and Mario Gaudino. The Journal of Thoracic and Cardiovascular Surgery, December, S0022-5223(23)01196-0.

Medical and Mechanical Circulatory Support of the Failing Right Ventricle. Yuriditsky, Eugene, Meshe Chonde, Oren Friedman, and James M. Horowitz. Current Cardiology Reports, December.

Cardiology 

Assessing and Managing Frailty in Advanced Heart Failure: An International Society for Heart and Lung Transplantation Consensus Statement. Denfeld, Quin E., Sunita R. Jha, Erik Fung, Tiny Jaarsma, Mathew S. Maurer, Gordon R. Reeves, Jonathan Afilalo, Nadine Beerli, Lavanya Bellumkonda, Sabina De Geest, Eiran Z. Gorodeski, Emer Joyce, Jon Kobashigawa, Oliver Mauthner, Julee McDonagh, Izabella Uchmanowicz, Victoria Vaughan Dickson, JoAnn Lindenfeld, and Peter Macdonald. The Journal of Heart and Lung Transplantation, November, S1053-2498(23)02028-4.

Informing Preconception Counseling: Outcomes Among Female Heart Transplant Recipients in the ISHLT Registry. Bhagra, Catriona J., Wida S. Cherikh, Heather Ross, Michelle M. Kittleson, Josef Stehlik, Alexandra Lewis, Ersilia M. DeFilippis, and Francesca Macera. The Journal of Heart and Lung Transplantation, December, S1053-2498(23)02165-4.

Potential Consequences of Cardioneuroablation for Vasovagal Syncope: ‘A Call for Appropriately Designed, Sham-Controlled Clinical Trials.’ Chakraborty, Praloy, Peng-Sheng Chen, Michael H. Gollob, Brian Olshansky, and Sunny S. Po. Heart Rhythm, December, S1547-5271(23)03000-X.

Life’s Essential 8 and Incident Hypertension Among US Hispanic/Latino Adults: Results From the Hispanic Community Health Study/Study of Latinos. Tremblay, Julien, Natalie A. Bello, Robert A. Mesa, Neil Schneiderman, Tatjana Rundek, Fernando D. Testai, Amber Pirzada, Martha Daviglus, Krista M. Perreira, Linda C. Gallo, Frank Penedo, Daniela Sotres-Alvarez, Sylvia Wassertheil-Smoller, and Tali Elfassy. Journal of the American Heart Association 12 (24): e031337.

Computational Biomedicine

Using Machine Learning Probabilities to Identify Effects of COVID-19. Ramlall, Vijendra, Undina Gisladottir, Jenna Kefeli, Yutaro Tanaka, Benjamin May, and Nicholas Tatonetti. Patterns (New York, N.Y.) 4 (12): 100889.

Imaging

Simplified Approach to Predicting Obstructive Coronary Disease With Integration of Coronary Calcium: Development and External Validation. Miller, Robert J. H., Heidi Gransar, Alan Rozanski, Damini Dey, Mouaz Al-Mallah, Benjamin J. W. Chow, Philipp A. Kaufmann, Filippo Cademartiri, Erica Maffei, Donghee Han, Piotr J. Slomka, and Daniel S. Berman. Journal of the American Heart Association 12 (24): e031601.

Medicine

The Impact of Preoperative Patient Education on Postoperative Pain, Opioid Use, and Psychological Outcomes: A Narrative Review. Darville-Beneby, Rasheeda, Anna M. Lomanowska, Hai Chuan Yu, Parker Jobin, Brittany N. Rosenbloom, Gretchen Gabriel, Helena Daudt, Michael Negraeff, Tania Di Renna, Maria Hudspith, and Hance Clarke. Canadian Journal of Pain = Revue Canadienne De La Douleur 7 (2): 2266751.

Cobimetinib Plus Vemurafenib in Patients With Solid Tumors With BRAF Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study. Meric-Bernstam, Funda, Michael Rothe, Pam K. Mangat, Elizabeth Garrett-Mayer, Rodolfo Gutierrez, Eugene R. Ahn, Timothy L. Cannon, Steven Powell, John C. Krauss, Christopher M. Reynolds, Margaret von Mehren, Deepti Behl, Carmen J. Calfa, Herbert L. Duvivier, Henry G. Kaplan, Michael B. Livingston, Manish R. Sharma, Walter J. Urba, Gina N. Grantham, Dominique C. Hinshaw, Abigail Gregory, Susan Halabi, and Richard L. Schilsky. JCO Precision Oncology 7 (September): e2300385.

Alcohol Intake Thresholds Among Individuals With Steatotic Liver Disease. Yeo, Yee Hui, Yixuan Zhu, Juan Pablo Arab, Wenjing Ni, Xiaoming Xu, Junping Shi, and Jie Li. JAMA Network Open 6 (12): e2347548.

Consuming Artificial Sweeteners May Alter the Structure and Function of Duodenal Microbial Communities. Hosseini, Ava, Gillian M. Barlow, Gabriela Leite, Mohamad Rashid, Gonzalo Parodi, Jiajing Wang, Walter Morales, Stacy Weitsman, Ali Rezaie, Mark Pimentel, and Ruchi Mathur. iScience 26 (12): 108530.

Perspectives of California Legislators on Institutional Barriers and Facilitators to Non-Partisan Research Evidence Use in State Health Policymaking. Ashtari, Neda, Justin Abbasi, and Elizabeth Barnert. Journal of General Internal Medicine, December.

Sumoylation of Methionine Adenosyltransferase Alpha 1 Promotes Mitochondrial Dysfunction in Alcohol-Associated Liver Disease. Floris, Andrea, Swati Chandla, Youngyi Lim, Lucia Barbier-Torres, Karina Seth, Arash Khangholi, Tony W. H. Li, Aaron Robison, Ben J. Murray, Sion Lee, Matsuda Michitaka, Ramachandran Murali, Maria Lauda Tomasi, and Shelly C. Lu. Hepatology (Baltimore, Md.), December.

A Randomized Controlled Trial of a Proactive Analgesic Protocol Demonstrates Reduced Opioid Use Among Hospitalized Adults With Inflammatory Bowel Disease. Berry, Sameer K., Will Takakura, Devin Patel, Rajalakshmi Govalan, Afsoon Ghafari, Elizabeth Kiefer, Shao-Chi Huang, Catherine Bresee, Teryl K. Nuckols, and Gil Y. Melmed. Scientific Reports 13 (1): 22396.

Pulmonary Fibrosis Stakeholder Summit: A Joint National Heart, Lung, and Blood Institute, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. Montesi, Sydney B., Christian R. Gomez, Michael Beers, Robert Brown, Ishanu Chattopadhyay, Kevin R. Flaherty, Christine Kim Garcia, Brigitte Gomperts, Lida P. Hariri, Cory M. Hogaboam, R. Gisli Jenkins, Naftali Kaminski, Grace Hyun J. Kim, Melanie Königshoff, Martin Kolb, Darrell N. Kotton, Jonathan A. Kropski, Joseph Lasky, Chelsea M. Magin, Toby M. Maher, Mark McCormick, Bethany B. Moore, Cheryl Nickerson-Nutter, Justin Oldham, Anna J. Podolanczuk, Ganesh Raghu, Ivan Rosas, Steven M. Rowe, William T. Schmidt, David Schwartz, Jessica E. Shore, Cathie Spino, Matthew Craig, and Fernando J. Martinez. American Journal of Respiratory and Critical Care Medicine, December.

Spatially Resolved Tumor Microenvironment Predicts Treatment Outcomes in Relapsed/Refractory Hodgkin Lymphoma. Aoki, Tomohiro, Aixiang Jiang, Alexander Xu, Yifan Yin, Alicia Gamboa, Katy Milne, Katsuyoshi Takata, Tomoko Miyata-Takata, Shanee Chung, Shinya Rai, Shaocheng Wu, Mary Warren, Celia Strong, Talia Goodyear, Kayleigh Morris, Lauren C. Chong, Monirath Hav, Anthony R. Colombo, Adele Telenius, Merrill Boyle, Susana Ben-Neriah, Maryse Power, Alina S. Gerrie, Andrew P. Weng, Aly Karsan, Andrew Roth, Pedro Farinha, David W. Scott, Kerry J. Savage, Brad H. Nelson, Akil Merchant, and Christian Steidl. Journal of Clinical Oncology, December, JCO2301115.

Causal Relationships Between Risk of Venous Thromboembolism and 18 Cancers: A Bidirectional Mendelian Randomization Analysis. Cornish, Naomi, Philip Haycock, Hermann Brenner, Jane C. Figueiredo, Tessel E. Galesloot, Robert C. Grant, Mattias Johansson, Daniela Mariosa, James McKay, Rish Pai, Andrew J. Pellatt, N. Jewel Samadder, Jianxin Shi, Florian Thibord, David-Alexandre Trégouët, Catherine Voegele, Chrissie Thirlwell, Andrew Mumford, Ryan Langdon, and InterLymph Consortium, INVENT-MVP Consortium. International Journal of Epidemiology, December, dyad170.

Identification of PRDX5 as a Target for the Treatment of Castration-Resistant Prostate Cancer. Wang, Rong, Yuanyuan Mi, Jiang Ni, Yang Wang, Lingwen Ding, Xuebin Ran, Qiaoyang Sun, Soo Yong Tan, H. Phillip Koeffler, Ninghan Feng, and Yong Q. Chen. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), December, e2304939.

Cytolethal Distending Toxin B Inoculation Leads to Distinct Gut Microtypes and IBS-D-like microRNA-Mediated Gene Expression Changes in a Rodent Model. Leite, Gabriela, Juliana de Freitas Germano, Walter Morales, Stacy Weitsman, Gillian M. Barlow, Gonzalo Parodi, Maya L. Pimentel, Maria Jesus Villanueva-Millan, Maritza Sanchez, Sarah Ayyad, Ali Rezaie, Ruchi Mathur, and Mark Pimentel. Gut Microbes 16 (1): 2293170.

Neurology

Case Report: A New Case of YARS1-Associated Autosomal Recessive Disorder With Compound Heterozygous and Concurrent 47, XXY. Kuan, Janene, Ashleigh Hansen, and Hua Wang. Frontiers in Pediatrics 11: 1282253.

Neurosurgery  

Superficial Siderosis and the Dura. Schievink, Wouter I. European Journal of Neurology, December, e16182.

Supracerebellar Infratentorial Resection of a Torcular Lesion Causing Fulminant Intracranial Hypertension: Illustrative Case. Dallas, Jonathan, Jessica R. Lane, Benjamin S. Hopkins, Melinda Chang, Mark Borchert, Nestor R. Gonzalez, Peter A. Chiarelli, and Jason K. Chu. Journal of Neurosurgery. Case Lessons 6 (25): CASE23363.

OBGYN

Association Between Adherence to Posttreatment National Comprehensive Cancer Network (NCCN) Surveillance Guidelines and Detection of Recurrent Uterine Cancer. Mayer, Christopher M., Reed M. O’Connor, Anthony T. Do, Victoria R. Cerda, Stephanie M. Wang, Marla E. Scott, Andrew J. Li, B. J. Rimel, Michael R. Manuel, Kristin N. Taylor, and Kenneth H. Kim. Gynecologic Oncology 181 (December): 8–11.

Orthopaedics

Is Single-Level Cervical Disc Arthroplasty Associated With a Lower Reoperation Rate Than Anterior Cervical Discectomy and Fusion? Tuchman, Alexander, Ida Chen, Corey T. Walker, Linda E. Kanim, Hyun W. Bae, and David L. Skaggs. Journal of Neurosurgery. Spine, December, 1–9.

The Impact of Novel Inflammation-Preserving Treatment towards Lumbar Disc Herniation Resorption in Symptomatic Patients: A Prospective, Multi-Imaging and Clinical Outcomes Study. Albert, Hanne B., Arash J. Sayari, J. Nicolas Barajas, Alexander L. Hornung, Garrett Harada, Michael T. Nolte, Ana V. Chee, Dino Samartzis, and Alexander Tkachev. European Spine Journal, December.

Pathology and Laboratory Medicine 

The Concise Guide to PHARMACOLOGY 2023/24: G Protein-Coupled Receptors. Alexander, Stephen P. H., Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Maria Pia Abbracchio, Richard D. Ye, et al. British Journal of Pharmacology 180 Suppl 2 (October): S23–144.

Slice Testing - Considerations From Ordering to Reporting: A Joint Report of the Association for Molecular Pathology, College of American Pathologists, and National Society of Genetic Counselors. SoRelle, Jeffrey A., Birgit H. Funke, Celeste C. Eno, Jianling Ji, Avni Santani, Pinar Bayrak-Toydemir, Megan Wachsmann, Karen E. Wain, and Rong Mao. The Journal of Molecular Diagnostics: JMD, December, S1525-1578(23)00293-3.

Surgery

Factors Associated With Postoperative Opioid Use in Adolescents. Odegard, Marjorie, Shadassa Ourshalimian, Donia Hijaz, Rachel Y. Goldstein, Romeo C. Ignacio, Stephanie Y. Chen, Eugene Kim, Eugene S. Kim, and Lorraine I. Kelley-Quon. Journal of Pediatric Surgery, November, S0022-3468(23)00694-2.

FOXC1 Restrains NF-κB-Mediated Interleukin-1β Transcription in Breast Cancer. Liu, Yan, Shuang Chen, Mao Tian, Armando Giuliano, and Xiaojiang Cui. MedComm 4 (6): e440.

RGCC-Mediated PLK1 Activity Drives Breast Cancer Lung Metastasis by Phosphorylating AMPKα2 to Activate Oxidative Phosphorylation and Fatty Acid Oxidation. Cheng, Shaojie, Xueying Wan, Liping Yang, Yilu Qin, Shanchun Chen, Yongcan Liu, Yan Sun, Yuxiang Qiu, Luyi Huang, Qizhong Qin, Xiaojiang Cui, Mingjun Wu, and Manran Liu. Journal of Experimental & Clinical Cancer Research: CR 42 (1): 342.

Outcomes and Endpoints of Postoperative Recurrence in Crohn’s Disease: Systematic Review and Consensus Conference. Hammoudi, Nassim, David Sachar, Geert D’Haens, Walter Reinisch, Paulo Gustavo Kotze, Severine Vermeire, Jürgen Schölmerich, Michael A. Kamm, Anne Griffiths, Julian Panes, Subrata Ghosh, Corey A. Siegel, Willem Bemelman, Colm O’Morain, Flavio Steinwurz, Phillip Fleshner, Gerassimos J. Mantzaris, Bruce Sands, Maria T. Abreu, Iris Dotan, Dan Turner, Axel Dignass, Matthieu Allez, and International Organization for the Study of Inflammatory Bowel Diseases (IOIBD). Journal of Crohn’s & Colitis, December, jjad205.

Urology

Bladder Instillation Patterns in a Cohort of Women With Interstitial Cystitis/Bladder Pain Syndrome. Niino, Clarissa A., Lauren N. Tholemeier, Catherine Bresee, Amanda M. De Hoedt, Kamil E. Barbour, Jayoung Kim, Stephen J. Freedland, and Jennifer T. Anger. Urogynecology (Philadelphia, Pa.) 29 (11): 914–19.

The Value of Residency Program Characteristics Changes Throughout Urology Training. Heard, John R., Karl-Ray Jeune, John M. Masterson, Peris R. Castaneda, Andrew G. Winer, and Andrew L. Freedman. The Canadian Journal of Urology 30 (6): 11724–31.

Is Size in the Eye of the Beholder? Visual Estimation of Penis Size Among Transgender and Cisgender People and Implications for Genital Gender-Affirming Surgery and Sexual Medicine. Castaneda, Peris R., Michael Zaliznyak, Sandeep S. Sandhu, Galen Cook-Wiens, Shannon M. Smith, Samhita Mallavarapu, and Maurice M. Garcia. The Journal of Sexual Medicine, December, qdad147.