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September
2022
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Faculty Publications: Sept. 1-8

A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Sept. 1-8. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week’s collection.

Anesthesiology

Regional Anesthesia in Trauma Patients: A Quality Improvement Study. Perlman, Ryan, and Sam Bonge. European Journal of Trauma and Emergency Surgery, September.

Cancer

Gut Microbiome and Pancreatic Cancer Cachexia: An Evolving Relationship. Hendifar, Andrew, Rasaq Akinsola, Hayato Muranaka, Arsen Osipov, Shant Thomassian, Natalie Moshayedi, Julianne Yang, Jonathan Jacobs, Suzanne Devkota, Neil Bhowmick, and Jun Gong. World Journal of Gastrointestinal Oncology 14 (7): 1218–26.

Reply. Lee, Yi-Te, Yazhen Zhu, Ju Dong Yang, Vatche G. Agopian, and Hsian-Rong Tseng. Hepatology (Baltimore, Md.), August.

Predicting Pathologic Lymph Node Positivity in CN0 Pharynx and Larynx Cancers. Anderson, Eric M., Michael Luu, Diana J. Lu, Eric M. Chung, Christopher Gay, Kevin S. Scher, Alain C. Mita, Jon Mallen-St Clair, Allen S. Ho, and Zachary S. Zumsteg. The Laryngoscope, August.

Risk-Reducing Mastectomy Decisions Among Women With Mutations in High- and Moderate- Penetrance Breast Cancer Susceptibility Genes. Comeaux, Jacob G., Julie O. Culver, John E. Lee, Danielle Dondanville, Heather L. McArthur, Emily Quinn, Nicholas Gorman, Charité Ricker, Ming Li, and Caryn Lerman. Molecular Genetics & Genomic Medicine, August, e2031.

Longitudinal Changes To Objectively Measured Physical Activity And Sedentary Behavior In Colorectal Cancer Survivors: 1762. Viskochil, Richard, Anjelica Ashworth, Tengda Lin, Caroline Himbert, Andreana Holowatyj, Anita Peoples, Sheetal Hardikar, Adetunji Toriola, Biljana Gigic, David Shibata, Christopher Li, Jane Figueiredo, Erin Siegel, Martin Schneider, Cornelia Ulrich, and Jennifer Ose. Medicine & Science in Sports & Exercise 54 (9S): 431.

Long-Term Efficacy and Safety of Brigatinib in Crizotinib-Refractory ALK+ NSCLC: Final Results of the Phase 1/2 and Randomized Phase 2 (ALTA) Trials. Gettinger, Scott N., Rudolf M. Huber, Dong-Wan Kim, Lyudmila Bazhenova, Karin Holmskov Hansen, Marcello Tiseo, Corey J. Langer, Luis G. Paz-Ares Rodríguez, Howard L. West, Karen L. Reckamp, Glen J. Weiss, Egbert F. Smit, Maximilian J. Hochmair, Sang-We Kim, Myung-Ju Ahn, Edward S. Kim, Harry J. M. Groen, Joanna Pye, Yuyin Liu, Pingkuan Zhang, Florin Vranceanu, and D. Ross Camidge. JTO Clinical and Research Reports 3 (9): 100385.

Collaborative Implementation of Malnutrition Screening for Cancer Patients. Laszlo, M., and A. Provisor. Journal of the Academy of Nutrition and Dietetics 122 (9, Supplement): A35.

Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma: The CANTATA Randomized Clinical Trial. Tannir, Nizar M., Neeraj Agarwal, Camillo Porta, Nicola J. Lawrence, Robert Motzer, Bradley McGregor, Richard J. Lee, Rohit K. Jain, Nancy Davis, Leonard J. Appleman, Oscar Goodman, Walter M. Stadler, Sunil Gandhi, Daniel M. Geynisman, Roberto Iacovelli, Begoña Mellado, Juan Manuel Sepúlveda Sánchez, Robert Figlin, Thomas Powles, Lalith Akella, Keith Orford, and Bernard Escudier. JAMA Oncology, September.

Is Time to Castration Resistant Prostate Cancer a Potential Intermediate End-Point for Time to Metastasis Among Men Initiating Androgen Deprivation Therapy for Non-Metastatic Prostate Cancer With Rapid PSA Doubling Time (<9 Months)? Klaassen, Zachary, Lauren Howard, Christopher J. D. Wallis, Jessica L. Janes, Amanda De Hoedt, William J. Aronson, Thomas J. Polascik, Christopher J. Amling, Christopher J. Kane, Matthew R. Cooperberg, Martha K. Terris, Yuan Wu, and Stephen J. Freedland. Prostate Cancer and Prostatic Diseases, September.

Phase I Trial of Bermekimab With Nanoliposomal Irinotecan and 5-Fluorouracil/Folinic Acid in Advanced Pancreatic Ductal Adenocarcinoma. Gong, Jun, Shant Thomassian, Sungjin Kim, Gillian Gresham, Natalie Moshayedi, Jason Y. Ye, Julianne C. Yang, Jonathan P. Jacobs, Simon Lo, Nick Nissen, Srinivas Gaddam, Mourad Tighiouart, Arsen Osipov, and Andrew Hendifar. Scientific Reports 12 (1): 15013.

RARγ: The Bone of Contention for Endothelial Cells in Prostate Cancer Metastasis. Bhowmick, Snigdha, and Neil A. Bhowmick. Cancer Research 82 (17): 2975–76.

Perspectives in Melanoma: Meeting Report From the Melanoma Bridge (December 2nd - 4th, 2021, Italy).  Ascierto, Paolo A., Sanjiv S. Agarwala, Christian Blank, Corrado Caracò, Richard D. Carvajal, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Jean-Jacques Grob, Omid Hamid, Michelle Krogsgaard, Roger S. Lo, Amanda W. Lund, Gabriele Madonna, Olivier Michielin, Bart Neyns, Iman Osman, Solange Peters, Poulikos I. Poulikakos, Sergio A. Quezada, Bradley Reinfeld, Laurence Zitvogel, Igor Puzanov, and Magdalena Thurin. Journal of Translational Medicine 20 (1): 391.

Clinical and Preclinical Therapies for Bladder Cancer Following BCG Failure. Nazmifar, Michael, Cheyenne Williams, Aurash Naser-Tavakolian, John Heard, Charles Rosser, Dan Theodorescu, and Michael Ahdoot. The Journal of Urology, September, 101097JU0000000000002957.

Cancer Risk and Gammopathies in 2123 Adults With Gaucher Disease Type 1 in the International Gaucher Group Gaucher Registry. Rosenbloom, Barry E., Maria Domenica Cappellini, Neal J. Weinreb, Marta Dragosky, Shoshana Revel-Vilk, Julie L. Batista, Davorka Sekulic, and Pramod K. Mistry. American Journal of Hematology 97 (10): 1337–47.

Cardiac Surgery 

Heart Transplantation Using Donation After Circulatory Death in the United States. Chen, Qiudong, Dominic Emerson, Dominick Megna, Asishana Osho, Amy Roach, Joshua Chan, Georgina Rowe, George Gill, Fardad Esmailian, Joanna Chikwe, Natalia Egorova, James K. Kirklin, Jon Kobashigawa, and Pedro Catarino.The Journal of Thoracic and Cardiovascular Surgery, May, S0022-5223(22)00533-5.

Cardiology

Survivors of Sudden Cardiac Arrest Presenting With Pulseless Electrical Activity: Clinical Substrate, Triggers, Long-Term Prognosis. Holmstrom, Lauri, Shiva Salmasi, Harpriya Chugh, Audrey Uy-Evanado, Chad Sorenson, Ziana Bhanji, Bai Madison Seifer, Ariik Sargsyan, Angelo Salvucci, Jonathan Jui, Kyndaron Reinier, and Sumeet S. Chugh. JACC. Clinical Electrophysiology, August, S2405-500X(22)00583-7.

Characteristics and Outcomes of Heart Transplant Recipients With a Pre-Transplant History of Malignancy. Youn, Jong-Chan, Darae Kim, Kyung An Kim, Jin-Jin Kim, In-Cheol Kim, Hye Sun Lee, Jin-Oh Choi, Eun-Seok Jeon, Keith Nishihara, Evan P. Kransdorf, David H. Chang, Michelle M. Kittleson, Jignesh K. Patel, Danny Ramzy, Fardad Esmailian, and Jon A. Kobashigawa. American Journal of Transplantation, September.

Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: An Observational Study of Women From Four US Cohorts. Hu, Jie, Jie Yao, Shuliang Dseng, Raji Balasubramanian, Monik C. Jiménez, Jun Li, Xiuqing Guo, Daniel E. Cruz, Yan Gao, Tianyi Huang, Oana A. Zeleznik, Debby Ngo, Simin Liu, Milagros C. Rosal, Rami Nassir, Nina P. Paynter, Christine M. Albert, Russell P. Tracy, Peter Durda, Yongmei Liu, Kent D. Taylor, W. Craig Johnson, Qi Sun, Eric B. Rimm, A. Heather Eliassen, Stephen S. Rich, Jerome I. Rotter, Robert E. Gerszten, Clary B. Clish, and Kathryn M. Rexrode. Circulation Research, September, 101161CIRCRESAHA121320134.

Regional Myocardial Perfusion Imaging in Predicting Vessel-Related Outcome: Interplay Between the Perfusion Results and Angiographic Findings. Mannarino, Teresa, Adriana D’Antonio, Roberta Assante, Emilia Zampella, Valeria Gaudieri, Pietro Buongiorno, Valeria Cantoni, Roberta Green, Carmela Nappi, Emanuele Criscuolo, Roberto Bologna, Mario Petretta, Piotr Slomka, Alberto Cuocolo, and Wanda Acampa. European Journal of Nuclear Medicine and Molecular Imaging, September.

Government Regulation and Percutaneous Coronary Intervention Volume, Access and Outcomes: Insights From the Washington State Cardiac Care Outcomes Assessment Program. Kataruka, Akash, Charles C. Maynard, Ravi S. Hira, Larry Dean, Todd Dardas, Hitinder Gurm, Josiah Brown, Michael E. Ring, and Jacob A. Doll. Journal of the American Heart Association 11 (17): e025607.

Ischemic Heart Disease in Young Women: JACC Review Topic of the Week. Minissian, Margo B., Puja K. Mehta, Sharonne N. Hayes, Ki Park, Janet Wei, C. Noel Bairey Merz, Leslie Cho, Annabelle Santos Volgman, Islam Y. Elgendy, Mamas Mamas, Melinda B. Davis, Harmony R. Reynolds, Kelly Epps, Kathryn Lindley, Malissa Wood, Odayme Quesada, Gregory Piazza, and Carl J. Pepine. Journal of the American College of Cardiology 80 (10): 1014–22.

Ethnicity and Sudden Cardiac Death: Why Are Some at Risk and Others Protected? Reinier, Kyndaron, and Sumeet S. Chugh. The Lancet Regional Health. Europe 22 (November): 100499.

The Two Pandemics. Kittleson, Michelle M. The American Journal of Medicine 135 (9): 1144–46.

Computational Biomedicine 

Vesalius: High-Resolution in Silico Anatomization of Spatial Transcriptomic Data Using Image Analysis. Martin, Patrick C. N., Hyobin Kim, Cecilia Lövkvist, Byung-Woo Hong, and Kyoung Jae Won. Molecular Systems Biology 18 (9): e11080.

Challenges and Opportunities for Mining Adverse Drug Reactions: Perspectives From Pharma, Regulatory Agencies, Healthcare Providers and Consumers. Gonzalez-Hernandez, Graciela, Martin Krallinger, Monica Muñoz, Raul Rodriguez-Esteban, Özlem Uzuner, and Lynette Hirschman. Database: The Journal of Biological Databases and Curation 2022 (September): baac071.

Emergency Medicine 

Quality Measures for Palliative Care in the Emergency Department. Goett, R., E. Isaacs, G. K. Chan, D. Wang, K. Aberger, R. Pearl, M. Rosenberg, A. J. Lofferdo, and S. Lamba. Academic Emergency Medicine, September.

Imaging

Influence of Intensive Lipid-Lowering on CT Derived Fractional Flow Reserve in Patients With Stable Chest Pain: Rationale and Design of the FLOWPROMOTE Study. Mortensen, Martin B., Niels-Peter Sand, Martin Busk, Jesper M. Jensen, Erik L. Grove, Damini Dey, Nadia Iraqi, Adam Updegrove, Tim Fonte, Ole N. Mathiassen, Susanne Hosbond, Hans E. Bøtker, Jonathon Leipsic, Jagat Narula, and Bjarne L. Nørgaard. Clinical Cardiology, September.

Medicine

Progress toward Better Treatment of Lupus. Wallace, Daniel J. The New England Journal of Medicine 387 (10): 939–40.

In Memoriam Vinay Sundaram (1978-2022). Jalan, Rajiv, Shelly Lu, and Alexander Kuo. Journal of Hepatology, September, S0168-8278(22)03004-5.

A Revised Hippocratic Oath for the Era of Digital Health. Meskó, Bertalan, and Brennan Spiegel. Journal of Medical Internet Research 24 (9): e39177.

Risk Factors Associated With Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients With Osteoarthritis. Silverman, Stuart, Patricia Schepman, J. Bradford Rice, Craig G. Beck, William Pajerowski, Alan G. White, Sheena Thakkar, Rebecca L. Robinson, and Birol Emir. Journal of Health Economics and Outcomes Research 9 (2): 47–56.

Geriatric Fracture Program Centering Age-Friendly Care Associated With Lower Length of Stay and Lower Direct Costs. Breda, Kathleen, Michelle S. Keller, Hiroshi Gotanda, Alexander Beland, Karma McKelvey, Carol Lin, and Sonja Rosen. Health Services Research, August.

Infections in Alcoholic Hepatitis. Kaur, Bhupinder, Russell Rosenblatt, and Vinay Sundaram. Journal of Clinical and Translational Hepatology 10 (4): 718–25.

Antagonizing CD105 and Androgen Receptor to Target Stromal-Epithelial Interactions for Clinical Benefit. Smith, Bethany N., Rajeev Mishra, Sandrine Billet, Veronica R. Placencio-Hickok, Minhyung Kim, Le Zhang, Frank Duong, Anisha Madhav, Kevin Scher, Nancy Moldawer, Amy Oppenheim, Bryan Angara, Sungyong You, Mourad Tighiouart, Edwin M. Posadas, and Neil A. Bhowmick. Molecular Therapy: The Journal of the American Society of Gene Therapy, August, S1525-0016(22)00507-X.

Nonalcoholic Fatty Liver Disease: Review of Management for Primary Care Providers. Basu, Rita, Mazen Noureddin, and Jeanne M. Clark. Mayo Clinic Proceedings 97 (9): 1700–1716.

Neurosurgery

Transplantation of Human Neural Progenitor Cells Secreting GDNF into the Spinal Cord of Patients With ALS: A Phase 1/2a Trial. Baloh, Robert H., J. Patrick Johnson, Pablo Avalos, Peggy Allred, Soshana Svendsen, Genevieve Gowing, Kristina Roxas, Amanda Wu, Becky Donahue, Sheryl Osborne, George Lawless, Brandon Shelley, Koral Wheeler, Carolyn Prina, Dana Fine, Tami Kendra-Romito, Haniah Stokes, Vicki Manoukian, Abirami Muthukumaran, Leslie Garcia, Maria G. Bañuelos, Marlesa Godoy, Catherine Bresee, Hong Yu, Doniel Drazin, Lindsey Ross, Robert Naruse, Harish Babu, Eric A. Macklin, Ashley Vo, Ashraf Elsayegh, Warren Tourtellotte, Marcel Maya, Matthew Burford, Frank Diaz, Chirag G. Patil, Richard A. Lewis, and Clive N. Svendsen. Nature Medicine, September.

Combined Transcranial and Endoscopic Endonasal Approach for Resection of a Complex Sinonasal Squamous Cell Carcinoma: Two-Dimensional Operative Video. Nisson, Peyton L., Michael Gaub, Gabriel S. Gonzales-Portillo, Nikolay Martirosyan, Christopher Le, and G. Michael Lemole. Journal of Neurological Surgery. Part B, Skull Base 83 (Suppl 3): e657–58.

Catastrophic Acute Failure of Pelvic Fixation in Adult Spinal Deformity Requiring Revision Surgery: A Multicenter Review of Incidence, Failure Mechanisms, and Risk Factors. Martin, Christopher T., Kenneth J. Holton, Benjamin D. Elder, Jeremy L. Fogelson, Anthony L. Mikula, Christopher J. Kleck, David Calabrese, Evalina L. Burger, David Ou-Yang, Vikas V. Patel, Han Jo Kim, Francis Lovecchio, Serena S. Hu, Kirkham B. Wood, Robert Harper, S. Tim Yoon, Dheera Ananthakrishnan, Keith W. Michael, Adam J. Schell, Isador H. Lieberman, Stanley Kisinde, Christopher J. DeWald, Michael T. Nolte, Matthew W. Colman, Frank M. Phillips, Daniel E. Gelb, Jacob Bruckner, Lindsey B. Ross, J. Patrick Johnson, Terrence T. Kim, Neel Anand, Joseph S. Cheng, Zach Plummer, Paul Park, Mark E. Oppenlander, Jonathan N. Sembrano, Kristen E. Jones, and David W. Polly. Journal of Neurosurgery. Spine, September, 1–9.

Surgical Treatment of Young Adults With Idiopathic Scoliosis. Walker, Corey T., Nitin Agarwal, Robert K. Eastlack, Gregory M. Mundis, Nima Alan, Tina Iannacone, Behrooz A. Akbarnia, and David O. Okonkwo. Journal of Neurosurgery. Spine, September, 1–7.

Nursing

2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Solution Set Oversight Committee. Lloyd-Jones, Donald M., Pamela B. Morris, Christie M. Ballantyne, Kim K. Birtcher, Ashleigh M. Covington, Sondra M. DePalma, Margo B. Minissian, Carl E. Orringer, Sidney C. Smith, Ashley Arana Waring, and John T. Wilkins. Journal of the American College of Cardiology, August.

OBGYN

Category II Intrapartum Fetal Heart Rate Patterns Unassociated With Recognized Sentinel Events: Castles in the Air. Mandel, Howard C. Obstetrics & Gynecology 140 (3): 522–23.

SGO and the Elephant That Is Still in the Room: Wellness, Burnout and Gynecologic Oncology. Davidson, B. A., T. B. Turner, K. H. Kim, I. Cass, L. Calat, G. McGwin, and D. M. Kushner. Gynecologic Oncology, September, S0090-8258(22)00572-8.

Orthopaedics

Chronic Warfarin Anticoagulation in Hip Fracture Patients Delays Surgery and Is Associated With Increased Risk of Postoperative Complications: A Multicenter Propensity Score Matched Analysis. Levack, Ashley E., Harold G. Moore, Stephen R. Stephan, Sally Jo, Ian G. Schroeder, John M. Garlich, Aidan Hadad, Milton T. M. Little, Anna N. Miller, Stephen Lyman, and Joseph M. Lane. Journal of Orthopaedic Trauma, August.

Comments on the Article ‘Grip Strength Measurement for Outcome Assessment in Common Hand Surgeries’: To the Editor. Kuschner, Stuart Harvey, Charles Lane, and Eva Williams. Clinics in Orthopedic Surgery 14 (3): 474–75.

Effects Of A Vibrating Foam Roller On The Work Of The Quadriceps And Hamstrings: 1842. Ruggieri, Rachel M., Jared W. Coburn, Andrew J. Galpin, and Pablo B. Costa. Medicine & Science in Sports & Exercise54 (9S): 546–47.

An Update on the Use of Orthobiologics Combined With Corrective Osteotomies for Osteoarthritis: Osteotomy Site and Intra-Articular Efficacy. Kerzner, Benjamin, Luc M. Fortier, Hasani W. Swindell, Johnathon R. McCormick, Luke B. Kasson, Mario Hevesi, Robert F. LaPrade, Bert R. Mandelbaum, and Jorge Chahla. Operative Techniques in Sports Medicine, OSTEOTOMIES ABOUT THE KNEE, 30 (3): 150933.

Gender and Outcomes in Total Joint Arthroplasty: A Systematic Review on Healthcare Disparities in the United States. McKeon, John F., Paul M. Alvarez, Andrew I. Spitzer, Chad A. Krueger, Matthew Pigott, Mengnai Li, and Sravya P. Vajapey. Current Orthopaedic Practice 33 (5): 466–72.

Pathology

NOR-1 (NR4A3) Immunostaining on Cytologic Preparations for the Preoperative Diagnosis of Acinic Cell Carcinoma of the Salivary Gland. Krishnan, Vimal, Luan Nguyen, Rulong Shen, David Lieu, Mariza De Peralta-Venturina, and Xuemo Fan. Journal of the American Society of Cytopathology, July, S2213-2945(22)00065-5.

Plexiform Fibrohistiocytic Tumor: A Clinicopathological and Immunohistochemical Study of 39 Tumors, With Evidence for a CSF1-Producing ‘Null Cell’ Population. Thangaiah, Judith Jebastin, Nooshin K. Dashti, Abbas Agaimy, Karen Fritchie, and Andrew L. Folpe. Virchows Archiv: An International Journal of Pathology, September.

Surgery

Consideration of Aesthetic Rhinoplasty in Children and Adolescents. House, Adrian E., Kyohei Itamura, and Babak Azizzadeh. Facial Plastic Surgery & Aesthetic Medicine, September.

Penetration of the Vestibule Following a History of Stapedectomy. Shohet, Jack A., Michela Borrelli, Tasha Nasrollahi, and Jonathan Raskin. Ear, Nose, & Throat Journal, September, 1455613221121501.