Faculty Publications: Sept. 8-15

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Sept. 8-15. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week’s collection.

Anesthesiology

Advanced Diagnostic and Therapeutic Techniques for Anaesthetists in Thoracic Trauma: An Evidence-Based Review. Pollock, Gabriel A., Jessie Lo, Henry Chou, Michael S. Kissen, Michelle Kim, Vida Zhang, Alexander Betz, and Ryan Perlman. British Journal of Anaesthesia, August, S0007-0912(22)00366-X.

Cancer

The Hedgehog Pathway in Hematopoiesis and Hematological Malignancy. Lemos, Tucker, and Akil Merchant. Frontiers in Oncology 12: 960943.

Characterization of MET Exon 14 Skipping Alterations (in NSCLC) and Identification of Potential Therapeutic Targets Using Whole Transcriptome Sequencing. Kim, So Yeon, Jun Yin, Stephen Bohlman, Phillip Walker, Sanja Dacic, Chul Kim, Hina Khan, Stephen V. Liu, Patrick C. Ma, Misako Nagasaka, Karen L. Reckamp, Jim Abraham, Dipesh Uprety, Feng Wang, Joanne Xiu, Jian Zhang, Haiying Cheng, and Balazs Halmos. JTO Clinical and Research Reports 3 (9): 100381.

Response to ‘Multicentre Selective Lymphadenectomy Trial 1: Key Primary Data Remain Unavailable.’ Faries, Mark B., Alistair J. Cochran, and John F. Thompson. The British Journal of Dermatology, August.

Lost on the Frontline, and Lost in the Data: COVID-19 Deaths Among Filipinx Healthcare Workers in the United States. Escobedo, Loraine A., Brittany N. Morey, Melanie D. Sabado-Liwag, and Ninez A. Ponce. Frontiers in Public Health 10: 958530.

EP08.02-019 Phase 1/2 Study of BLU-701, a Highly Selective EGFR Inhibitor, in Patients With EGFR-Mutant Non-Small Cell Lung Cancer. Spira, A., D. R. Spigel, R. Camidge, A. J. de Langen, T. M. Kim, K. Goto, Y. Elamin, E. Shum, K. L. Reckamp, J. Rotow, S. Goldberg, S. Gadgeel, T. A. Leal, F. Albayya, S. Fitzpatrick, M. Louie-Gao, J. Parepally, A. Zalutskaya, and H. Yu. Journal of Thoracic Oncology, Proceedings of the American Society for Radiation Oncology 64th Annual Meeting, 17 (9, Supplement): S406.

EP08.02-045 Phase 1/2 Study of BLU-945 in Patients With Common Activating EGFR-Mutant Non-Small Cell Lung Cancer. Shum, E., Y. Elamin, Z. Piotrowska, D. R. Spigel, K. L. Reckamp, J. Rotow, D. S. W. Tan, S. M. Lim, T. M. Kim, C. -C. Lin, T. Kato, J. Parepally, F. Albayya, M. Louie-Gao, T. Weining, A. Zalutskaya, and K. Goto. Journal of Thoracic Oncology, Proceedings of the American Society for Radiation Oncology 64th Annual Meeting, 17 (9, Supplement): S418.

MA10.05 High Levels of CD47 Expression in Thymic Epithelial Tumors. Sun, T. Y., B. Nguyen, S. Chen, Y. Natkunam, S. Padda, M. van de Rijn, H. Wakelee, and J. Riess. Journal of Thoracic Oncology, Proceedings of the American Society for Radiation Oncology 64th Annual Meeting, 17 (9, Supplement): S79.

Phase II Study Combining Pembrolizumab With Aromatase Inhibitor in Patients With Metastatic Hormone Receptor Positive Breast Cancer. Ge, Xuan, Susan E. Yost, Jin Sun Lee, Paul H. Frankel, Christopher Ruel, Yujie Cui, Mireya Murga, Aileen Tang, Norma Martinez, Samuel Chung, Christina Yeon, Daphne Stewart, Daneng Li, Swapnil Rajurkar, George Somlo, Joanne Mortimer, James Waisman, and Yuan Yuan. Cancers 14 (17): 4279.

Risk Stratification and Early Detection Biomarkers for Precision Hepatocellular Carcinoma Screening. Lee, Yi-Te, Naoto Fujiwara, Ju Dong Yang, and Yujin Hoshida. Hepatology (Baltimore, Md.), September.

Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis-Starvation Along With Chemotherapy. Liu, Yixuan, Kai Guo, Min Ding, Bingchen Zhang, Nanyang Xiao, Zonghao Tang, Zhengming Wang, Chengfei Zhang, and Quazi T. H. Shubhra. ACS Applied Materials & Interfaces, September.

Urine Biomarkers Enable Pancreatic Cancer Detection up to 2 Years Before Diagnosis. Debernardi, Silvana, Oleg Blyuss, Daria Rycyk, Kirtiman Srivastava, Christie Y. Jeon, Hui Cai, Qiuyin Cai, Xiao-Ou Shu, and Tatjana Crnogorac-Jurcevic. International Journal of Cancer, September.

Associations of Individual and Combined Physical Activity and Body Mass Index Groups With Pro-Inflammatory Biomarkers Among Colorectal Cancer Patients. Himbert, Caroline, Christy A. Warby, Biljana Gigic, Jennifer Ose, Tengda Lin, Richard Viskochil, Anita R. Peoples, Anjelica Ashworth, Petra Schrotz-King, Courtney L. Scaife, Jessica N. Cohan, Jolanta Jedrzkiewicz, Peter Schirmacher, William M. Grady, Stacey A. Cohen, Mukta Krane, Jane C. Figueiredo, Adetunji T. Toriola, Erin M. Siegel, David Shibata, June L. Round, Lyen C. Huang, Christopher I. Li, Martin Schneider, Alexis Ulrich, Sheetal Hardikar, and Cornelia M. Ulrich. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, September, EPI-22-0681.

Cardiac Surgery 

Extracorporeal Life Support as a Bridge to Lung Transplantation: Where Are We Now? Patterson, Caroline M., Aakash Shah, Joseph Rabin, Laura DiChiacchio, Marcelo Cypel, Konrad Hoetzenecker, Pedro Catarino, and Christine L. Lau. The Journal of Heart and Lung Transplantation, June, S1053-2498(22)01985-4.

A Multi-Institutional Needs Assessment in the Development of a Robotic Surgery Curriculum: Perceptions From Resident and Faculty Surgeons. Imai, Taryne, Farin Amersi, Areti Tillou, Van Chau, Harmik Soukiasian, and Matthew Lin. Journal of Surgical Education, September, S1931-7204(22)00191-X.

Cardiology

Rapid Quantification of COVID-19 Pneumonia Burden From Computed Tomography With Convolutional Long Short-Term Memory Networks. Killekar, Aditya, Kajetan Grodecki, Andrew Lin, Sebastien Cadet, Priscilla McElhinney, Aryabod Razipour, Cato Chan, Barry D. Pressman, Peter Julien, Peter Chen, Judit Simon, Pal Maurovich-Horvat, Nicola Gaibazzi, Udit Thakur, Elisabetta Mancini, Cecilia Agalbato, Jiro Munechika, Hidenari Matsumoto, Roberto Menè, Gianfranco Parati, Franco Cernigliaro, Nitesh Nerlekar, Camilla Torlasco, Gianluca Pontone, Damini Dey, and Piotr Slomka. Journal of Medical Imaging (Bellingham, Wash.) 9 (5): 054001.

The Role of the Preventive Cardiologist in Addressing Climate Change. Gulati, Martha. American Journal of Preventive Cardiology 11 (September): 100375.

Impact of Left Ventricular Global Longitudinal Strain on Outcomes After Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation. Yoon, Sung-Han, Moody Makar, Saibal Kar, Keita Koseki, Luke Oakley, Navjot Sekhon, Dhairya Patel, Tarun Chakravarty, Mamoo Nakamura, Michele Hamilton, Jignesh K. Patel, Siddharth Singh, Skaf Sabah, Robert J. Siegel, Jeroen J. Bax, and Raj R. Makkar. The American Journal of Cardiology, September, S0002-9149(22)00832-3.

Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Alotaibi, Mona, Junzhe Shao, Michael W. Pauciulo, William C. Nichols, Anna R. Hemnes, Atul Malhotra, Nick H. Kim, Jason X.-J. Yuan, Timothy Fernandes, Kim M. Kerr, Laith Alshawabkeh, Ankit A. Desai, Andreea M. Bujor, Robert Lafyatis, Jeramie D. Watrous, Tao Long, Susan Cheng, Stephen Y. Chan, and Mohit Jain. Chest, September, S0012-3692(22)03706-0.

Disparities in Geographic Access to Cardiac Rehabilitation in Los Angeles County. Ebinger, Joseph E., Roy Lan, Matthew P. Driver, Parker Rushworth, Eric Luong, Nancy Sun, Trevor-Trung Nguyen, Sarah Sternbach, Amy Hoang, Jacqueline Diaz, Mallory Heath, Brian L. Claggett, C. Noel Bairey Merz, and Susan Cheng. Journal of the American Heart Association, September, e026472.

Cell Therapy Attenuates Endothelial Dysfunction in Hypertensive Rats With Heart Failure and Preserved Ejection Fraction. Couto, Geoffrey de, Thassio Mesquita, Xiaokang Wu, Alex Rajewski, Feng Huang, Akbarshakh Akhmerov, Na Na, Di Wu, Yizhou Wang, Liang Li, My Tran, Peter Kilfoil, Eugenio Cingolani, and Eduardo Marbán. American Journal of Physiology. Heart and Circulatory Physiology, September.

ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response. Yildirim, Asli D., Mevlut Citir, Asli E. Dogan, Zehra Veli, Zehra Yildirim, Ozlem Tufanli, Alexis Traynor Kaplan, Carsten Schultz, and Ebru Erbay. Journal of Lipid Research, September, 100279.

Outcomes After Transcatheter Edge-to-Edge Mitral Valve Repair According to Mitral Regurgitation Etiology and Cardiac Remodeling. Yoon, Sung-Han, Moody Makar, Saibal Kar, Tarun Chakravarty, Luke Oakley, Navjot Sekhon, Keita Koseki, Mamoo Nakamura, Michele Hamilton, Jignesh K. Patel, Siddharth Singh, Sabah Skaf, Robert J. Siegel, Jeroen J. Bax, and Raj R. Makkar. JACC. Cardiovascular Interventions 15 (17): 1711–22.

Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction. Butler, Javed, Gerasimos Filippatos, Tariq Jamal Siddiqi, João Pedro Ferreira, Martina Brueckmann, Edimar Bocchi, Michael Böhm, Vijay K. Chopra, Nadia Giannetti, Tomoko Iwata, James L. Januzzi, Sanjay Kaul, Ileana L. Piña, Piotr Ponikowski, Ursula Rauch-Kröhnert, Sanjiv J. Shah, Michele Senni, Mikhail Sumin, Subodh Verma, Jian Zhang, Stuart J. Pocock, Faiez Zannad, Milton Packer, and Stefan D. Anker. Circulation, September, 101161CIRCULATIONAHA122059755.

Computational Biomedicine 

Patient-Reported Reasons for Switching or Discontinuing Statin Therapy: A Mixed Methods Study Using Social Media. Golder, Su, Davy Weissenbacher, Karen O’Connor, Sean Hennessy, Robert Gross, and Graciela Gonzalez Hernandez. Drug Safety 45 (9): 971–81.

Medicine

Experiences of Women With Interstitial Cystitis/Bladder Pain Syndrome: What Can We Learn From Women’s Online Discussions? Gonzalez, Gabriela, Kristina Vaculik, Carine Khalil, Yuliya Zektser, Corey W. Arnold, Christopher V. Almario, Brennan M. R. Spiegel, and Jennifer T. Anger. The Journal of Urology, September, 101097JU0000000000002955.

Gastroparesis in Pregnancy. Sarvee, Moosavi, Min Yang Won, Wong Melissa, and Rezaie Ali. American Journal of Obstetrics and Gynecology, September, S0002-9378(22)00723-2.

Neurosurgery

Regulating Microglial MiR-155 Transcriptional Phenotype Alleviates Alzheimer’s-Induced Retinal Vasculopathy by Limiting Clec7a/Galectin-3+ Neurodegenerative Microglia. Shi, Haoshen, Zhuoran Yin, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Miyah R. Davis, Jered W. Wilson, Milica A. Margeta, Kristen M. Pitts, Shawn Herron, Seiko Ikezu, Tsuneya Ikezu, Stuart L. Graham, Vivek K. Gupta, Keith L. Black, Mehdi Mirzaei, Oleg Butovsky, and Maya Koronyo-Hamaoui. Acta Neuropathologica Communications 10 (1): 136.

OBGYN

Association of Primary Cesarean Delivery Rate With Dissemination of Nurse-Specific Cesarean Delivery Rates. Greene, Naomi H., Nicole Schwartz, and Kimberly D. Gregory. Obstetrics and Gynecology, September.

Immune Transcriptional Profiles in Mothers With Clinically Elevated Depression and Anxiety Symptoms Several Years Post-Delivery. Nicoloro-SantaBarbara, Jennifer M., Judith E. Carroll, Margo Minissian, Sarah J. Kilpatrick, Steve Cole, C. Noel Bairey Merz, and Eynav E. Accortt. American Journal of Reproductive Immunology (New York, N.Y.: 1989), September.

Orthopaedics

Lower Risk of Revision Surgery After Arthroscopic Versus Open Irrigation and Débridement for Shoulder Septic Arthritis. Upfill-Brown, Alexander, Brendan Shi, Matthew Carter, Carlos Maturana, Chistopher Hart, Akash A. Shah, Dane Brodke, Peter Hsiue, Christos Photopoulos, Christopher Lee, and Alexandra Stavrakis. The Journal of the American Academy of Orthopaedic Surgeons, September.

The Benefit of Addressing Malalignment In Revision Surgery for Proximal Junctional Kyphosis Following ASD Surgery. Passias, Peter G., Oscar Krol, Tyler K. Williamson, Virginie Lafage, Renaud Lafage, Justin S. Smith, Breton Line, Shaleen Vira, Shaina Lipa, Alan Daniels, Bassel Diebo, Andrew Schoenfeld, Jeffrey Gum, Khaled Kebaish, Paul Park, Gregory Mundis, Richard Hostin, Manush Gupta, Robert Eastlack, Neel Anand, Christopher Ames, Robert Hart, Douglas Burton, Frank J. Schwab, Christopher Shaffrey, Eric Klineberg, Shay Bess, and International Spine Study Group. Spine, September.

Pediatrics

Genomic and Phenotypic Characterization of 404 Individuals With Neurodevelopmental Disorders Caused by CTNNB1 Variants. Kayumi, Sayaka, Luis A. Pérez-Jurado, María Palomares, Sneha Rangu, Sarah E. Sheppard, Wendy K. Chung, Michael C. Kruer, Mira Kharbanda, David J. Amor, George McGillivray, Julie S. Cohen, Sixto García-Miñaúr, Mark A. Corbett, et al. Genetics in Medicine, September, S1098-3600(22)00897-8.

Surgery

National Prevalence of IC/BPS in Women and Men Utilizing Veterans Health Administration Data. Anger, Jennifer T., Kai B. Dallas, Catherine Bresee, Amanda M. De Hoedt, Kamil E. Barbour, Katherine J. Hoggatt, Marc T. Goodman, Jayoung Kim, and Stephen J. Freedland. Frontiers in Pain Research (Lausanne, Switzerland) 3: 925834.

Differential Epigenetic Status and Responses to Stressors Between Retinal Cybrids Cells With African Versus European Mitochondrial DNA: Insights into Disease Susceptibilities. Atilano, Shari R., Sina Abedi, Narcisa V. Ianopol, Mithalesh K. Singh, J. Lucas Norman, Deepika Malik, Payam Falatoonzadeh, Marilyn Chwa, Anthony B. Nesburn, Baruch D. Kuppermann, and M. Cristina Kenney. Cells 11 (17): 2655.

Herpes Simplex Virus 1 Glycoproteins Differentially Regulate the Activity of Costimulatory Molecules and T Cells. Matundan, Harry H., Ujjaldeep Jaggi, and Homayon Ghiasi. MSphere, September, e0038222.

Editorial Comment. Naser-Tavakolian, Aurash, Michael Nazmifar, and Michael Ahdoot. The Journal of Urology, September, 101097JU000000000000292102.