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2022
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Faculty Publications: Aug. 11-18

A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Aug. 11-18. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week’s collection.

Biomedical Sciences 

On the Surface-to-Bulk Partition of Proteins in Extracellular Vesicles. Zendrini, Andrea, Giorgia Guerra, Krizia Sagini, Tatyana Vagner, Dolores Di Vizio, and Paolo Bergese. Colloids and Surfaces. B, Biointerfaces218 (July): 112728.

Cancer

Gastrointestinal Stromal Tumors (GIST): A Population-Based Study Using the SEER Database, Including Management and Recent Advances in Targeted Therapy. Khan, Jaffar, Asad Ullah, Abdul Waheed, Nabin Raj Karki, Nawaraj Adhikari, Lakshmi Vemavarapu, Sami Belakhlef, Samy Malik Bendjemil, Siamak Mehdizadeh Seraj, Feroze Sidhwa, Intisar Ghleilib, Shahin Foroutan, Andrew M. Blakely, Jaydira Del Rivero, Nagla Abdel Karim, Eric Vail, Saleh Heneidi, and Hector Mesa. Cancers 14 (15): 3689.

A Qualitative Study of Online Information-Seeking Preferences Among Cancer Survivors. Budenz, Alexandra, Alix G. Sleight, and William M. P. Klein. Journal of Cancer Survivorship: Research and Practice 16 (4): 892–903.

Outcomes Following Abiraterone Versus Enzalutamide for Prostate Cancer: A Scoping Review. Shah, Yash B., Amy L. Shaver, Jacob Beiriger, Sagar Mehta, Nikita Nikita, William Kevin Kelly, Stephen J. Freedland, and Grace Lu-Yao. Cancers 14 (15): 3773.

Hypoxia-Inducible Factor Pathway Genes Predict Survival in Metastatic Clear Cell Renal Cell Carcinoma. Tamukong, Patrick K., Paige Kuhlmann, Sungyong You, Shengchen Su, Yanping Wang, Samantha Yoon, Jun Gong, Robert A. Figlin, Jessica L. Janes, Stephen J. Freedland, Susan Halabi, Eric J. Small, Brian I. Rini, and Hyung L. Kim. Urologic Oncology, August, S1078-1439(22)00268-X.

Cardiac Surgery 

Early Results of Geometric Ring Annuloplasty for Bicuspid Aortic Valve Repair During Aortic Aneurysm Surgery. Gerdisch, Marc W., T. Brett Reece, Dominic Emerson, Richard S. Downey, Geoffrey B. Blossom, Arun Singhal, Joshua N. Baker, Theodor J. M. Fischlein, Vinay Badhwar, and BAVr Working Group. JTCVS Techniques 14 (August): 55–65.

Cardiology

Artificial Intelligence Applications in Cardio-Oncology: Leveraging High Dimensional Cardiovascular Data. Chen, Haidee, David Ouyang, Tina Baykaner, Faizi Jamal, Paul Cheng, and June-Wha Rhee. Frontiers in Cardiovascular Medicine 9: 941148.

Transplanting COVID-19 Positive Donors: Expanding Our Experience to Widen the Donor Pool. Peled, Yael, and Michelle M. Kittleson. The Journal of Heart and Lung Transplantation, July, S1053-2498(22)02032-0.

Kinetics of Cellular and Humoral Responses to Third BNT162B2 COVID-19 Vaccine Over Six Months in Heart Transplant Recipients - Implications for the Omicron Variant: Correspondence. Peled, Yael, Jignseh K. Patel, Arnon Afek, and Michal Mandelboim. The Journal of Heart and Lung Transplantation, July, S1053-2498(22)02044-7.

Awareness of SARS-CoV-2 Omicron Variant Infection Among Adults With Recent COVID-19 Seropositivity. Joung, Sandy Y., Joseph E. Ebinger, Nancy Sun, Yunxian Liu, Min Wu, Amber B. Tang, John C. Prostko, Edwin C. Frias, James L. Stewart, Kimia Sobhani, and Susan Cheng. JAMA Network Open 5 (8): e2227241.

Usefulness of Computed Tomography to Predict Residual Mitral Regurgitation After Transcatheter Mitral Valve Edge-to-Edge Repair. Kaewkes, Danon, Vivek Patel, Tomoki Ochiai, Nir Flint, Keita Koseki, Ofir Koren, Rohan Sharma, Jeffrey Tyler, Yeunjung Kim, Siddharth Singh, Moody Makar, Tarun Chakravarty, Mamoo Nakamura, and Raj Makkar. Journal of Cardiology, August, S0914-5087(22)00195-2.

Assessing the Relationship Between Molecular Rejection and Parenchymal Injury in Heart Transplant Biopsies. Madill-Thomsen, Katelynn S., Jeff Reeve, Arezu Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Goekler, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann, and Philip F. Halloran. Transplantation, August.

Computational Biomedicine 

Bias or Biology? Importance of Model Interpretation in Machine Learning Studies From Electronic Health Records. Momenzadeh, Amanda, Ali Shamsa, and Jesse G Meyer. JAMIA Open 5 (3): ooac063.

Imaging

Relationship of Plaque Features at Coronary CT to Coronary Hemodynamics and Cardiovascular Events. Yang, Seokhun, Masahiro Hoshino, Bon-Kwon Koo, Taishi Yonetsu, Jinlong Zhang, Doyeon Hwang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, and Jagat Narula. Radiology, August, 213271.

Medicine

The Systemic Anti-Microbiota IgG Repertoire Can Identify Gut Bacteria That Translocate Across Gut Barrier Surfaces. Vujkovic-Cvijin, Ivan, Hugh C. Welles, Connie W. Y. Ha, Lutfi Huq, Shreni Mistry, Jason M. Brenchley, Giorgio Trinchieri, Suzanne Devkota, and Yasmine Belkaid. Science Translational Medicine 14 (658): eabl3927.

Sex Bias in Systemic Lupus Erythematosus: A Molecular Insight. Bose, Moumita, and Caroline Jefferies. Immunometabolism (Cobham (Surrey, England)) 4 (3): e00004.

Geographic Variation in Medicare Fee-for-Service Health Care Expenditures Before and After the Passage of the Affordable Care Act. 2021. Sood, Neeraj, Zhiyou Yang, Peter Huckfeldt, José Escarce, Ioana Popescu, and Teryl Nuckols. JAMA Health Forum 2 (12): e214122.

Association of Body Composition in Early Pregnancy With Gestational Diabetes Mellitus: A Meta-Analysis. Rahnemaei, Fatemeh Alsadat, Fatemeh Abdi, Reza Pakzad, Seyedeh Hajar Sharami, Fatemeh Mokhtari, and Elham Kazemian. PloS One 17 (8): e0271068.

Editorial: Interaction Between Endocrine and Exocrine Pancreas. Li, Ling, and S. J. Pandol. Frontiers in Endocrinology 13: 967066.

Impact of Obesity on Risk of Hospitalization, Surgery and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. Gu, Phillip, Jiyu Luo, Jihoon Kim, Paulina Paul, Berkeley Limketkai, Jenny S. Sauk, Sunhee Park, Nimisha Parekh, Kai Zheng, Vivek Rudrapatna, Gaurav Syal, Christina Ha, Dermot P. McGovern, Gil Y. Melmed, Phillip Fleshner, Samuel Eisenstein, Sonia Ramamoorthy, Parambir S. Dulai, Brigid S. Boland, Eduardo Grunvald, Uma Mahadevan, Lucila Ohno-Machado, William J. Sandborn, and Siddharth Singh. The American Journal of Gastroenterology, June.

Interactive Inflammatory Bowel Disease Biologics Decision Aid Does Not Improve Patient Outcomes Over Static Education: Results From a Randomized Trial. Almario, Christopher V., Welmoed K. van Deen, Michelle Chen, Rebecca Gale, Stéphanie Sidorkiewicz, So Yung Choi, Nirupama Bonthala, Christina Ha, Gaurav Syal, Taylor Dupuy, Xiaoyu Liu, Gil Y. Melmed, and Brennan M. R. Spiegel. The American Journal of Gastroenterology, June.

Safety of Teaching Endoscopic Ultrasound-Guided Gastroenterostomy (EUS-GE) Can Be Improved With Standardization of the Technique. Park, Kenneth H., Ulysses S. Rosas, Quin Y. Liu, Laith H. Jamil, Kapil Gupta, Srinivas Gaddam, Nicholas Nissen, Christopher C. Thompson, and Simon K. Lo. Endoscopy International Open 10 (8): E1088–94.

Question Prompt List as a Communication Tool for Adults With Gastroesophageal Reflux Disease: Incorporation of Patients’ Perspectives. Kamal, Afrin, Edgar Achkar, Dustin Carlson, John Clarke, Ronnie Fass, Chandra Prakash Gyawali, David A. Katzka, Dhyanesh Patel, Roberto Penagini, Ali Rezaie, Sabine Roman, Edoardo Savarino, Nicholas J. Shaheen, and George Triadafilopoulos. Journal of Clinical Gastroenterology 56 (7): 565–70.

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. Blonde, Lawrence, Guillermo E. Umpierrez, Janet B. McGill, S. Sethu Reddy, Sarah L. Berga, Michael Bush, Suchitra Chandrasekaran, Ralph A. DeFronzo, Daniel Einhorn, Rodolfo Galindo, Thomas W. Gardner, Rajesh Garg, W. Timothy Garvey, Irl B. Hirsch, Daniel L. Hurley, Kenneth Izuora, Mikhail Kosiborod, Darin Olson, Shailendra Patel, Rodica Pop-Busui, Archana R. Sadhu, Susan L. Samson, Carla Stec, William V. Tamborlane, Katherine R. Tuttle, Christine Twining, Adrian Vella, Priyathama Vellanki, and Sandra L. Weber. Endocrine Practice, August, S1530-891X(22)00576-6.

Butyrate-Producing Bacteria and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES). Cui, Jinrui, Gautam Ramesh, Martin Wu, Elizabeth T. Jensen, Osa Crago, Alain G. Bertoni, Chunxu Gao, Kristi L. Hoffman, Patricia A. Sheridan, Kari E. Wong, Alexis C. Wood, Yii-Der I. Chen, Jerome I. Rotter, Joseph F. Petrosino, Stephen S. Rich, and Mark O. Goodarzi. Diabetes, August, db220168.

Crohn’s Disease in Endoscopic Remission, Obesity, and Cases of High Genetic Risk Demonstrates Overlapping Shifts in the Colonic Mucosal-Luminal Interface Microbiome. Jacobs, Jonathan P., Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Maomeng Tong, Paul Ruegger, Talin Haritunians, Carol Landers, Philip Fleshner, Eric Vasiliauskas, Andrew Ippoliti, Gil Melmed, David Shih, Stephan Targan, James Borneman, Albert J. Fornace, Dermot P. B. McGovern, and Jonathan Braun. Genome Medicine 14 (1): 91.

Reports of Hospital Diabetes Meeting 2022. Jingtong Huang,  Andrea M. Yeung, Kevin T. Nguyen,  Nicole Y. Xu, Jean-Charles Preiser, Robert J. Rushakoff, Jane Jeffrie Seley, Guillermo E. Umpierrez, Amisha Wallia, Andjela T. DrincicRoma Gianchandani, Cecilia Lansang, Umesh Masharani, Nestoras Mathioudakis, Francisco J. Pasquel, Signe Schmidt, Viral N. Shah, Elias K. Spanakis, Andreas Stuhr, Gerlies M. Treiber, David C. Klonoff, Journal of Diabetes Science and Technology. First Published July 29, 2022 Research Article.

Neurology

Hospital Practices and Clinical Outcomes Associated With Behavioral Symptoms in Persons With Dementia. Tannenbaum, Rachel, Marie Boltz, Anum Ilyas, Valeria Gromova, Suzanne Ardito, Mutahira Bhatti, Gwenyth Mercep, Michael Qiu, Gisele Wolf-Klein, Zaldy S. Tan, Jason Wang, and Liron Sinvani. Journal of Hospital Medicine, August.

Effect of GBCA Use on Detection and Diagnostic Performance of the Central Vein Sign: Evaluation Using a 3T FLAIR* Sequence in Patients With Suspected Multiple Sclerosis. Daboul, Lynn, Carly M. O’Donnell, Quy Cao, Moein Amin, Paulo Rodrigues, John Derbyshire, Christina Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter Calabresi, Bruce A. C. Cree, Leorah Freeman, Roland G. Henry, Erin E. Longbrake, Kunio Nakamura, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D. Samudralwar, Suradech Suthiphosuwan, Matthew K. Schindler, Elias S. Sotirchos, Nancy L. Sicotte, Andrew J. Solomon, Russell T. Shinohara, Daniel S. Reich, Daniel Ontaneda, and Pascal Sati. AJR. American Journal of Roentgenology, August.

Neurosurgery

THE RETINA AS A TOOL FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASE. Wood, Keren, Idit Maharshak, Yosef Koronyo, and Maya Koronyo-Hamaoui. Harefuah 161 (8): 523–25.

Signature Effects of Vector-Guided Systemic Nano Bioconjugate Delivery Across Blood-Brain Barrier of Normal, Alzheimer’s, and Tumor Mouse Models. Israel, Liron L., Anna Galstyan, Alysia Cox, Ekaterina S. Shatalova, Tao Sun, Mohammad-Harun Rashid, Zachary Grodzinski, Antonella Chiechi, Dieu-Trang Fuchs, Rameshwar Patil, Maya Koronyo-Hamaoui, Keith L. Black, Julia Y. Ljubimova, and Eggehard Holler. ACS Nano, August.

In Reply: Placement of Stereotactic Electroencephalography Depth Electrodes Using the Stealth Autoguide Robotic System: Technical Methods and Initial Results. Mamelak, Adam N. Operative Neurosurgery (Hagerstown, Md.) 23 (3): e218–19.

OBGYN

Geotemporal Analysis of Perinatal Care Changes and Maternal Mental Health: An Example From the COVID-19 Pandemic. Hendrix, Cassandra L., Denise Werchan, Carly Lenniger, Jennifer C. Ablow, Ananda B. Amstadter, Autumn Austin, Vanessa Babineau, G. Anne Bogat, Leigh-Anne Cioffredi, Elisabeth Conradt, Sheila E. Crowell, Dani Dumitriu, Amy J. Elliott, William Fifer, Morgan Firestein, Wei Gao, Ian Gotlib, Alice Graham, Kimberly D. Gregory, Hanna Gustafsson, Kathryn L. Havens, Christine Hockett, Brittany R. Howell, Kathryn L. Humphreys, Nancy Jallo, Lucy S. King, Patricia A. Kinser, Alytia A. Levendosky, Joseph S. Lonstein, Maristella Lucchini, Rachel Marcus, Catherine Monk, Sara Moyer, Maria Muzik, Amy K. Nuttall, Alexandra S. Potter, Cynthia Rogers, Amy Salisbury, Lauren C. Shuffrey, Beth A. Smith, Christopher D. Smyser, Lynne Smith, Elinor Sullivan, Judy Zhou, Natalie H. Brito, and Moriah E. Thomason. Archives of Women’s Mental Health, August.

Long-Term Changes in Plasma Proteomic Profiles in Premenopausal and Postmenopausal Black and White Women: The Atherosclerosis Risk in Communities Study. Appiah, Duke, Pamela J. Schreiner, James S. Pankow, Guy Brock, Weihong Tang, Faye L. Norby, Erin D. Michos, Christie M. Ballantyne, and Aaron R. Folsom. Menopause (New York, N.Y.), August.

Orthopaedics

Evaluation and Management of Adult Footdrop. Haupt, Edward T., Jeremy Y. Chan, Max Michalski, and David B. Thordarson. JAAOS - Journal of the American Academy of Orthopaedic Surgeons 30 (16): 747–56.

Comparison of the Neer Classification to the 2018 Update of the Orthopedic Trauma Association/AO Fracture Classification for Classifying Proximal Humerus Fractures. Marmor, Meir T., Julie Agel, Jarrod Dumpe, James F. Kellam, Geoffrey S. Marecek, Eric Meinberg, Mai P. Nguyen, Stephen Sims, Gillian L. Soles, and Matthew D. Karam. OTA International 5 (3): e200.

Pathology

Clinicopathologic and Proteomic Characteristics of Intratubular Cytoplasmic AL Amyloidosis.Javaugue, Vincent, Alejandro Best Rocha, Samar M. Said, Dominick Santoriello, Jean Hou, Surendra Dasari, Jason D. Theis, Julie A. Vrana, Ibrahim Batal, Christopher Larsen, Glen S. Markowitz, Vivette D. D’Agati, Ellen D. McPhail, Nelson Leung, and Samih H. Nasr. Kidney International, August, S0085-2538(22)00614-7.

Claudin-18. Wong, Mary T., Aatur D. Singhi, Brent K. Larson, Carissa A. T. Huynh, Bonnie L. Balzer, Miguel Burch, Deepti Dhall, Alexandra Gangi, Jun Gong, Maha Guindi, Andrew E. Hendifar, Stacey A. Kim, Mariza de Peralta-Venturina, and Kevin M. Waters. Archives of Pathology & Laboratory Medicine, August.

Pediatrics

A Deep Invertible 3-D Facial Shape Model for Interpretable Genetic Syndrome Diagnosis. Bannister, Jordan J., Matthias Wilms, J. David Aponte, David C. Katz, Ophir D. Klein, Francois P. J. Bernier, Richard A. Spritz, Benedikt Hallgrimsson, and Nils D. Forkert. IEEE Journal of Biomedical and Health Informatics 26 (7): 3229–39.

Further Clinical Delineation of Microcephaly-Capillary Malformation Syndrome. Postma, Julianne K., Jessica L. Zambonin, Ebtissal Khouj, Suad Alyamani, John M. Graham, Fowzan S. Alkuraya, Stephen Kundell, and Melissa T. Carter. American Journal of Medical Genetics. Part A, August.

Analysis of INSPPIRE-2 Cohort: Risk Factors and Disease Burden in Children With Acute Recurrent or Chronic Pancreatitis. Uc, Aliye, Gretchen Cress, Fuchenchu Wang, Maisam A. Abu-El-Haija, Kate M. Ellery, Douglas S. Fishman, Cheryl E. Gariepy, Tanja Gonska, Tom K. Lin, Quin Liu, Megha Mahta, Asim Maqbool, Brian A. McFerron, Veronique D. Morinville, Chee Y. Ooi, Emily R. Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Jose Serrano, Uzma Shah, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E. Lowe, and Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer. Journal of Pediatric Gastroenterology and Nutrition, August.

Radiation Oncology 

ASTRO Supports Access to Evidence-Based Cancer Care for All Patients, Regardless of Pregnancy Status, and Protection for Physicians Recommending and Providing Evidence-Based Care. Jacobson, Geraldine M., Gopal K. Bajaj, John M. Buatti, Laura Dawson, Curtiland Deville, Thomas J. Eichler, Beth Erickson, Eric Ford, Iris C. Gibbs, Constantine Mantz, Brian Marples, Jeff M. Michalski, Howard Sandler, Benjamin Smith, Neha Vapiwala, and Catheryn Yashar. International Journal of Radiation Oncology, Biology, Physics, August, S0360-3016(22)02602-5.

Surgery

Overtransfusion of Packed Red Blood Cells During Massive Transfusion Activation: A Potential Quality Metric for Trauma Resuscitation. Barmparas, Galinos, Raymond Huang, William G. Lee, Yassar M. Hashim, Samuel H. Pepkowitz, Ellen B. Klapper, and Daniel R. Margulies. Trauma Surgery & Acute Care Open 7 (1): e000896.

Infratemporal Fossa Abscesses: A Systematic Review of Cases. Young, Kurtis, Dennis M. Tang, and Arthur W. Wu. Ear, Nose, & Throat Journal, August, 1455613221121040.

Management of Post-Infectious Anosmia and Hyposmia: A Systematic Review. Nag, Amit K., Abdul K. Saltagi, Mohamad Z. Saltagi, Arthur W. Wu, Thomas S. Higgins, Anna Knisely, Jonathan Y. Ting, and Elisa A. Illing. The Annals of Otology, Rhinology, and Laryngology, August, 34894221118186.

Retained Dental Implant in the Maxillary Sinus. Liu, Derek, Sophie Jang, Jeffrey D. Suh, Michela Borrelli, Tasha Nasrollahi, Jonathan Raskin, and Elisabeth H. Ference. Ear, Nose, & Throat Journal, August, 1455613221121043.