Personal Statement

Dr. Seki’s early research career focused on the study of Toll-like receptors in Kupffer cells. He then combined his immunology research background with the study of chronic liver diseases, including liver fibrosis, alcohol-associated liver disease (ALD), and nonalcoholic fatty liver disease (NAFLD). Dr. Seki’s current research interest is the study of innate immune signaling and the signaling induced by extracellular cellular matrix hyaluronan (HA) in the development of liver fibrosis, NAFLD and liver malignancy. Our research team has expertise in basic liver research using genetically modified animals and primary cultured liver cells (hepatocytes, Kupffer cells and hepatic stellate cells), and translational research of human liver diseases.