Center for Bioinformatics and Functional Genomics

The Cedars-Sinai Center for Bioinformatics and Functional Genomics (CBFG) is an integrated, interdisciplinary research group established in 2016, with the common goal of developing end-to-end research workflows for genomic and high-throughput functional analysis of patient samples. Led by director, Simon Gayther, PhD, the primary goals of the CBFG are to establish a research nexus that integrates leading-edge developments in computational sciences, next-generation genomics and epigenomics, and to use functional biology to improve our understanding of disease etiology applied to personalized health.

Preventing the Spread of Deadly Breast Cancer

Researchers have found that limiting asparagine in the diet could reduce cancer’s ability to spread.


What genetics is doing is allowing us to imagine a future in which, based on individual screening, we can give a patient actionable advice."

Simon Gayther, PhD

Barth Family Chair in Cancer Genetics in honor of Beth Y. Karlan, MD
Director, Molecular Epidemiology
Director, Center for Bioinformatics and Functional Genomics

Bioinformatics—Study of Large-Scale Datasets

Data from biological sequencing, medical records, databases, mobile devices and more play an important role in precision medicine.

Research Laboratories

Our laboratories form an integrated, interdisciplinary research group solving vexing problems and discovering new treatments.

Research in the Berman Laboratory focuses on understanding the basic logic of noncoding regulatory sequences and how the sequences control the local and 3-D structure of chromatin to control transcription. 

Research in the Gayther Laboratory focuses on the discovery of genetic variants using next-generation sequencing and genotyping technologies.

The Hazelett Laboratory is working to understand how genetic variation contributes to disease etiology.

The goal of the Knott Laboratory is to develop cancer treatment strategies that are focused on the hetero-cellular interactions within tumors that drive disease progression.

Finding Opportunities in Disease Studies

The Center for Bioinformatics and Functional Genomics was featured in the Thought Leadership Film Series at The American Society of Human Genetics 2018 Annual Meeting in San Diego.

Job Openings

Postdoctoral Scientist (Knott Laboratory)

The Knott Laboratory, part of the Center for Bioinformatics and Functional Genomics at Cedars-Sinai, is seeking a computational biologist postdoctoral scientist that is interested in applying single cell profiling technologies to study breast cancer progression. The Knott Lab is currently focused on developing molecular and computational tools to study the mechanisms that cancer cells employ to metastasize and evade therapy. The lab is particularly interested in next-generation therapeutics that target the interactions between malignant and nonmalignant tumor cell types, such as immune checkpoint inhibitors. Learn more and apply now.

Research Associate III (Gayther Laboratory)

The Gayther Laboratory, part of the Center for Bioinformatics and Functional Genomics (CBFG) at Cedars-Sinai, is looking for a Research Associate III/Lab Manager to join the team. The CBFG brings together teams specializing in bioinformatics and computational biology, functional analysis of the genome coupled with next generation sequencing and genome editing to provide a complete pipeline for identifying the functional consequences of identified risk loci. The Gayther Lab is largely focused on defining the functional role of both common and rare risk variants in the development of ovarian, breast and prostate cancer. Learn more and apply now.

Genetic Variants in DNA for Cancer

Precision medicine includes combining data, a team of experts and technology to search for ways to use genetics to prevent disease and develop new interventions for the treatment of cancer.

Have Questions or Need Help?

Contact us if you have questions, or wish to learn more about bioinformatics and functional genomics research at Cedars-Sinai.

8723 Alden Drive, Suite 100
Los Angeles, CA 90048

Center for Bioinformatics and Functional Genomics