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Non-alcoholic Fatty Liver Disease (NAFLD)


Non-alcoholic fatty liver disease (NAFLD) is caused by a buildup of fat in the liver and is the most common form of liver disease in the United States. It affects patients who drink little to no alcohol.

The fatty deposits occur when the liver is no longer able to breakdown fats easily, causing them to accumulate in the liver.

In some cases, these deposits will cause inflammation and damage to the liver, leading to the more severe form of this condition, non-alcoholic steatohepatits (NASH). NASH can lead to scarring of the liver, a potentially life-threatening condition called cirrhosis.


There are often no outward signs or symptoms associated with NAFLD. The most common symptoms are:

  • Fatigue
  • Pain in the upper right abdomen (usually mild)

NASH may lead to cirrhosis of the liver, causing one or more of the following symptoms as the condition progresses:

Causes and Risk Factors

NAFLD is most common in patients who are overweight or obese.

Other risk factors include:


Due to the fact that NAFLD can be difficult to diagnose, patients should seek an experienced medical team, such as the Cedars-Sinai Fatty Liver Program, which uses the most advanced diagnostic technology available and continues to investigate new ways to identify the disease.

Diagnosis generally begins with a physical exam and a review of the patient's medical history. If NAFLD is suspected, blood tests will be done to determine how the liver is working. Imaging tools, such as magnetic resonance imaging (MRI), or ultrasound may also be used to help.

If NASH is suspected, the patient will undergo a liver biopsy. During this procedure, a needle is used to remove a small piece of tissue from the liver, which will then be examined under a microscope. This allows the physician to determine if any scarring or inflammation of the liver tissue has occurred. Patients are usually sedated during the liver biopsy.

The Fatty Liver Program also uses special MRI technology, called MR-EFF (elastography fat fraction), to determine the percentage of fat and scarring present. This non-invasive diagnostic tool may eliminate the need for a liver biopsy.


The knowledgeable and highly trained experts in the Fatty Liver Program are dedicated to providing each patient with the best possible treatment.

While there is no standard treatment for patients with NAFLD, lifestyle changes have been shown to affect its progression. This may include losing weight, maintaining a healthy diet, or addressing underlying conditions such as hypothyroidism.

The Fatty Liver Program takes an integrated approach to treatment, combining nutritional and lifestyle expertise and support with access to the latest clinical trials and research.

It is important for patients with NAFLD to avoid consuming excessive alcohol as this can contribute to the condition.

© 2000-2022 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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