The Goodridge Laboratory studies the development and function of neutrophils, monocytes, macrophages and dendritic cells. These innate immune cells play key roles in anti-microbial defense and inflammation, as well as in tissue development, repair and regeneration.
During their development from hematopoietic stem and progenitor cells (HSPCs) in the bone marrow and upon release into the circulation and tissues, these cells are constantly influenced by signals from their microenvironment that regulate their production (e.g. influence cell fate decisions) and program their function (e.g. inflammatory or immunosuppressive).
The lab’s major focus is on defining mechanisms and pathways of myeloid cell production by HSPCs (myelopoiesis). We are particularly interested in understanding how transcription factors determine progenitor fate, and how microenvironmental signals such as microbial components and cytokines program the function of the cells as they differentiate.
Our other main interest is in how aging of the immune system impacts the function of tissues such as the brain and skeletal muscle. In particular, we are investigating how rejuvenation of the immune system impacts cognition and muscle repair.
Understanding the molecular mechanisms that regulate the development and function of myeloid cells is revealing their roles in disease development and opportunities for therapeutic intervention.
- Pattern recognition receptors – detection of microbial components by TLRs and Dectin-1
- Immune modulation by parasites
- Adjuvant properties of fungal β-glucans
- Innate immune memory due to microbial detection by HSPCs
- Role of gut microbes in promoting myelopoiesis
- Role of the transcription factor IRF8 in myelopoiesis