Photodynamic Therapy for Age-Related Macular Degeneration

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What is photodynamic therapy for AMD?

Photodynamic therapy is a treatment for the eyes. It uses a laser and a special medicine that works when exposed to a certain type of laser light. It is done to treat age-related macular degeneration (AMD). AMD is a condition that can lead to vision loss.

The retina is the layer of cells in the back of your eye. It changes light into electrical signals. Your retina then sends these signals to your brain. AMD affects your macula. The macula is the sensitive, central part of your retina. This area is responsible for your detailed, central vision. AMD damages your macula. The macula may become thinner as a result. Blood vessels may start growing under your retina. This can cause fluid to leak under your macula. This excess fluid can lead to vision loss.

Just before the procedure, an eye doctor (ophthalmologist) injects a medicine into a vein in your arm. This medicine is sensitive to light. It collects in the abnormal blood vessels under your macula. You are then given an anesthetic eye drop. Using a special contact lens, the eye doctor then shines a laser into your eye. The light from the laser activates the medicine. The medicine then creates blood clots in the abnormal blood vessels under your retina. This seals off the vessels. This can help prevent more vision loss.

Why might I need photodynamic therapy for AMD?

Photodynamic therapy is one type of treatment for AMD. AMD is a common cause of major eyesight loss in older adults. In rare cases, it can lead to blindness. It affects your macula. So you may still have your side (peripheral) vision if you have AMD. It may cause a sudden or slow loss of your central vision.

AMD comes in 2 main types: dry and wet. Only the wet type has abnormal blood vessel growth. Photodynamic therapy is advised only as a possible therapy for wet type AMD.

Photodynamic therapy often doesn't restore vision that you have already lost. But it may slow down the damage to your central vision.

Photodynamic therapy is an option only for some people with wet type AMD. It may be advised if your vision loss happens slowly over time, not suddenly. The treatment is used less often now that there are new medicines to reduce abnormal blood vessel growth. But your healthcare provider may advise the therapy in addition to these new medicines.

What are the risks of photodynamic therapy for AMD?

All procedures have risks. The risks of this procedure include:

A new blind spot
Back pain linked to injecting the medicine
Photosensitivity reactions such as sunburn, if your skin is exposed to direct sunlight right after the procedure
Reactions where you had the light-activated medicine injected
Short-term (temporary) or lifelong (permanent) loss of visual sharpness, which is rarely severe

Your risks may differ according to your age, other health problems, and the specific anatomy of your AMD. Ask your eye doctor about your risks for the procedure.

The effects of the therapy are often short-term. This is because the abnormal blood vessels may open up again.

How do I get ready for photodynamic therapy for AMD?

Ask your eye doctor what you need to do to get ready for photodynamic therapy. Ask if you need to stop taking any medicines before the procedure.

Your eye doctor may want to use special tools to shine a light in your eye and examine the back of your eye. You will need to have your eyes dilated for this eye exam. Your eye doctor might order other special tests to get even more information about your eye.

Before the procedure, eye drops will be used to dilate your pupil. It will stay dilated for several hours after the procedure.

What happens during photodynamic therapy for AMD?

It is most often done as an outpatient procedure in an eye doctor’s office or eye clinic. This means you will go home the same day. During a typical procedure:

You will be given an injection of the light-sensitive medicine.
You will be awake during the procedure. You may be given a medicine to help you relax.
You will be given anesthetic eye drops to make sure you don’t feel anything.
You will have a special contact lens placed on your eye. This helps the laser focus on exactly the right spot on the back of your eye.
Your eye doctor will shine the laser in the exact spot in your eye. This will activate the light-sensitive medicine. The medicine will form blood clots in the abnormal vessels under your macula. This seals off the abnormal blood vessels.
Your eye may be covered for a short time.

What happens after photodynamic therapy for AMD?

Ask your eye doctor about what you should expect after your procedure. You should be able to go home the same day. Plan to have someone go home with you after the procedure.

For a few days after the procedure, your eyes and skin will be more sensitive to light. This is due to the light-sensitive medicine. During this time, you will need to stay indoors and stay out of direct sunlight. If you must go outside, use dark glasses and protective clothing. Ask your eye doctor when it is safe for you to go outside again.

Your eye may be a little sore after the procedure. Talk with your eye doctor about taking over-the-counter pain medicine. Follow your eye doctor’s orders about eye care and medicines.

You will need close follow-up care with your eye doctor. He or she will closely watch you for complications and keep managing your treatment for AMD. Tell your eye doctor right away if you have decreased vision or increased eye redness, swelling, or pain. Your vision may be blurry for a short while after the procedure. But this often goes away.