Osteosarcoma

What causes osteosarcoma?

The exact cause of osteosarcoma is not known. But it is believed to be due to DNA changes (mutations) inside bone cells. These are either inherited or acquired after birth.

Who is at risk for osteosarcoma?

A risk factor is anything that may increase your chance of having a disease. The exact cause of someone’s cancer may not be known. But risk factors can make it more likely for a person to have cancer. Some risk factors may not be in your control. But others may be things you can change.

Risk factors for osteosarcoma include:

• Teenage growth spurts
• Being tall for a specific age
• Having treatment with radiation for another cancer, especially at a young age or with high doses of radiation
• Some noncancer (benign) bone diseases

Genetics also plays a role in risk. Risk factors also include certain rare, inherited disorders, such as:

• Li-Fraumeni syndrome. A rare family predisposition to multiple types of cancers (such as soft tissue sarcomas, breast cancer, brain tumors, osteosarcoma, and others) caused by a mutation in a gene—often the p53 tumor-suppressor gene—that normally curbs cancer.
• Rothmund-Thompson syndrome. A rare inherited syndrome that includes skeletal problems, rashes, short stature, and an increased risk of developing osteosarcoma. It is caused by an abnormality in the REQL4 gene.
• Hereditary retinoblastoma. A cancer of the eye that often happens in children younger than 4 years old.

Talk with your healthcare provider about your risk factors for osteosarcoma and what you can do about them.

What are the symptoms of osteosarcoma?

The following are the most common symptoms for osteosarcoma. But each person may have slightly different symptoms. Symptoms may include:

• Pain in the affected bone or joint that gets worse over time
• Swelling around the affected site
• Increased pain with activity or lifting
• A broken bone with no clear cause
• Limping
• Decreased movement of the affected limb

The symptoms of osteosarcoma are a lot like the symptoms for other health conditions. Always talk with your healthcare provider for a diagnosis.

How is osteosarcoma diagnosed?

In addition to a complete health history and physical exam, diagnostic procedures for osteosarcoma may include various tests.

You may have imaging tests of the tumor and sites of possible metastasis. You may have 1 or more of these:

• X-ray. A diagnostic test that uses beams of radiation to make images of internal tissues, bones, and organs on film.
• Bone scans. A nuclear imaging method to evaluate any degenerative or arthritic changes in the joints. It can also find bone diseases and tumors. And it can find the cause of bone pain or inflammation.
• MRI. This procedure uses a combination of large magnets, radiofrequencies, and a computer to make detailed images of organs and structures in the body. This test is done to better define a mass seen on an X-ray and to look for any nearby spread of tumors.
• CT scan. This imaging test uses X-rays and a computer to make detailed images of the body. A CT scan shows details of the bones, muscles, fat, and organs.
• Positron emission tomography (PET) scan. Radioactive-tagged sugar (glucose) is injected into the bloodstream. Tissues that use the glucose more than normal tissues (such as tumors) can be found by a scanning machine. PET scans can be used to find small tumors that have spread.

You may have other tests, such as:

• Complete blood count (CBC). This test measures the size, number, and maturity of different blood cells in a specific volume of blood.
• Other blood tests. These might include tests to check for certain substances in your blood.
• Biopsy of the tumor. Small pieces of the tumor, called tissue samples, are removed (with a needle or during surgery) from the body. The samples are then checked under a microscope to see if cancer or other abnormal cells are present.

After a diagnosis of osteosarcoma, you’ll likely have other tests. These help your healthcare providers learn more about the cancer. They’ll show how much and how far the cancer has spread (metastasized) in your body. A stage grouping is then assigned.

How is osteosarcoma staged?

How is osteosarcoma treated?

Treatment will depend on your symptoms, age, and general health. It will also depend on how severe the condition is.

Treatment may include:

• Surgery to remove the tumor. This is the main treatment for most people.
• Chemotherapy to kill cancer cells anywhere in the body
• Radiation therapy to kill cancer cells and shrink tumors. It might be used after surgery to kill any cancer cells that may be left behind.
• Rehabilitation, including physical and occupational therapy, and psychosocial adapting
• Supportive care for the side effects of treatment

Many people, particularly those with higher grade tumors, will receive a combination of treatments. Some types of treatment may later affect fertility. If this side effect is permanent, it might cause infertility. This means you may not be able to have children. Both men and women can be affected.

Talk with your healthcare providers about your treatment options. Make a list of questions. Think about the benefits and possible side effects of each option. Discuss your concerns with your healthcare provider before making a decision.

How do I manage osteosarcoma?

Managing a cancer diagnosis can be a life-changing event for both the person and the family. Each person decides how to adapt to the diagnosis. If physically able, some people find it helpful to keep their prediagnosis daily routine such as spending time with family and friends, going to work, and taking part in trips and other activities. Other people find the diagnosis life-changing and decide to rethink how they spend their time. An important factor in your decision will be the long-term outlook, or prognosis, for the osteosarcoma.

The prognosis for osteosarcoma depends on:

• The extent of the disease
• The size and location of the tumor
• The pathologic grade of the cancer
• The tumor's response to treatment
• Your age and overall health
• Your tolerance of specific medicines, procedures, or therapies
• The type of treatment used
• Your treatment preferences

As with any cancer, prognosis and long-term survival can vary greatly from person to person. Every person is unique and treatment and prognosis is structured around your needs. Prompt medical care and aggressive therapy are important for the best outcomes. Continuous follow-up care is vital for a person diagnosed with osteosarcoma. Side effects of radiation and chemotherapy, including second cancers, can happen in survivors.

In addition to the physical impact of a cancer diagnosis and treatment, managing the emotional, money, and legal issues linked to the cancer can be overwhelming. Ask your healthcare team for help if you are concerned about issues in any of these areas. They will have community resources that may be able to help you and your family.

Key points about osteosarcoma

• Osteosarcoma is a type of bone cancer that often develops in the osteoblast cells that form bone.
• The bone the cancer cells make is not as strong as normal bone.
• It happens most often in children, teens, and young adults.
• It can start in any bone in the body. But it most often starts in the long bones around the knee. Other common sites are the upper leg, the lower leg, and the upper arm bone.
• Treatment may include surgery, radiation, chemotherapy, and physical and occupational therapy.

Next steps

Tips to help you get the most from a visit to your healthcare provider:

• Know the reason for your visit and what you want to happen.
• Before your visit, write down questions you want answered.
• Bring someone with you to help you ask questions and remember what your provider tells you.
• At the visit, write down the name of a new diagnosis and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
• Know why a new medicine or treatment is prescribed and how it will help you. Also know what the side effects are.
• Ask if your condition can be treated in other ways.
• Know why a test or procedure is recommended and what the results could mean.
• Know what to expect if you do not take the medicine or have the test or procedure.
• If you have a follow-up appointment, write down the date, time, and purpose for that visit.
• Know how you can contact your provider if you have questions.