Surgical Indirect Revascularization

Condition: Stroke


Key Inclusion Criteria

  • Transient ischemic attack or non-severe stroke within 30 days of enrollment
  • Modified Rankin scale score of ≤3
  • 30-80 years old. Patients 30 to 49 years old are required to meet additional criteria.

Key Exclusion Criteria

  • Tandem extracranial or intracranial narrowing or obstruction that is proximal or distal to the target lesion
  • Bilateral intracranial vertebral artery narrowing of 70 percent to 99 percent and uncertainty about which artery is symptomatic
  • Stenting, angioplasty, or endarterectomy of an extracranial or intracranial artery within 30 days before enrollment

Full Study Name

Surgical Indirect Revascularization for Symptomatic Intracranial Arterial Stenosis (IRB no. 44887)


This study focuses on patients who have been evaluated and/or treated by a neurosurgeon and/or neurologist at Cedars-Sinai for symptomatic intracranial stenosis. The purpose of the study is to evaluate the outcomes of a surgical approach called indirect revascularization (encephaloduroarteriosynangiosis or EDAS) for narrowing of the blood vessels in the brain. Researchers will also compare imaging and clinical outcomes to those of patients who have received only medical management.


Phase II

Principal Investigator

Nestor Gonzalez, MD


Laurie Paletz, BSN, PHN, RN-BC SCRN