WISE CVD - Continuation (WISE HFpEF)

Condition: Cardiovascular disease

Eligibility

Key Inclusion Criteria

For women undergoing invasive coronary angiography:

  • At least 18 years old
  • Symptomatic angina or anginal equivalent

For women and men with HFpEF:

  • At least 18 years old
  • Symptoms of heart failure
  • Preserved ejection fraction, left ventricular ejection fraction ≥45% prior to study entry

Key Exclusion Criteria

For women undergoing invasive coronary angiography:

  • Obstructive coronary artery disease ≥50% luminal diameter stenosis in ≥1 epicardial coronary artery
  • History of coronary artery bypass grafting, coronary stent, or valve repair/replacement

For women and men with HFpEF:

  • Current LVEF <45%
  • History of coronary artery bypass grafting, coronary stent, or valve repair/replacement

Full Study Name

Women's Ischemia Syndrome Evaluation (WISE) - Coronary Microvascular Dysfunction (CMD) and Heart Failure With Preserved Ejection Fraction (HFpEF) (IRB no. 37321)

Summary

This study focuses on women undergoing clinically-ordered coronary angiography for suspected coronary microvascular dysfunction (small vessel disease), or men or women with heart failure with preserved ejection fraction (HFpEF). Researchers aim to better understand HFpEF (inadequate heart muscle function in the setting of preserved muscle pumping) for therapeutic strategy development and optimized noninvasive cardiac MRI for the diagnosis and management of coronary microvascular dysfunction and HFpEF.

Women undergoing clinically-ordered coronary angiography and coronary reactivity testing for suspected small vessel disease will be asked to perform rest-stress cardiac magnetic resonance imaging (CMRI) and Millar stress testing. The invasive coronary angiography and coronary reactivity testing are conducted as part of standard-of-care procedures; information from these tests will be accessed from the participant's records. Men or women with HFpEF will be asked to perform computed coronary tomography angiography to evaluate for obstructive coronary artery disease, followed by rest-stress CMRI.


Principal Investigator

C. Noel Bairey Merz, MD

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