Hydrogen Sulfide in Diarrheal Conditions

Condition: Small intestinal bacterial overgrowth, diarrhea


Key Inclusion Criteria

  • At least 18 years old

Key Exclusion Criteria

  • Treatment with antibiotics or pregnancy
  • Recent colonoscopy (within 30 days)
  • Recent antibiotic use (within 30 days)

Full Study Name

Exploring the Role of Hydrogen Sulfide in Diarrheal Conditions (IRB no. 54140)

The purpose of this study is to find ways to decrease levels of a gas called hydrogen sulfide.  Hydrogen sulfide gas is made by microbes (bugs) in the gut and is linked to small intestinal bacterial overgrowth (SIBO). SIBO is a condition in which there is an excess amount of microbes within the gut (specifically, the small intestine), which can lead to symptoms such as abdominal pain and diarrhea. Researchers aim to test various ways of decreasing levels of the microbes that produce hydrogen sulfide gas, and therefore provide relief from SIBO symptoms.

Researchers will compare levels of hydrogen sulfide gas among participants and will use samples to test potential treatments. This study involves the investigational use of Integrated Breath Sample System (IBS-S). 

Financial disclosure: Mark Pimentel, MD, a co-investigator on this study, receives payment from the company sponsoring this study; he serves as a consultant and has received speaker fees from the sponsor. Additionally, Dr. Pimentel has filed a patent, copyright, or other intellectual property directly related to this research.  At this time, there is no financial value associated with this filed patent, however, it is possible that he could receive royalty income or may receive future royalty income should the patent be licensed in the future. Cedars-Sinai may also receive royalties or other payments from the sponsor under the license agreement for the patent related to this research.

Principal Investigator
Nipaporn Pichetshote, MD

Medically Associated Science and Technology (MAST) Program Office
Phone: 310-423-0617
E-mail: mastprogram@cshs.org