Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Muscosal Immunol. 2018 Sep;11(5):1466-1476. https://www.nature.com/articles/s41385-018-0055-y.
Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. Enhanced utilization of induced pluripotent stem cell-derived human intestinal organoids using microengineered chips. Cell Mol Gastroenterol Hepatol. 2017 Dec 29;5(4):669-677.e2. https://www.clinicalkey.com/#!/content/journal/1-s2.0-S2352345X1730187X.
Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR. Association of ribonuclease T2 gene polymorphisms with decreased expression and clinical characteristics of severity in Crohn’s disease. Gastroenterology. 2017 Jul;153(1):219-232. https://www.sciencedirect.com/science/article/pii/S0016508517354124.
Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR. Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunol. 2014 Nov;7(6)1492-1503. https://www.nature.com/articles/mi201437
Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol. 2012 Feb;180(2):636-649. https://www.sciencedirect.com/science/article/pii/S0002944011010182.
Gonsky R, Deem RL, Bream JH, Lee DH, Young HA, Targan SR. Mucosa-specific Targets for regulation of IFN-gamma expression: lamina propria T cells use different cis-elements than peripheral blood T cells to regulate transactivation of IFN-gamma expression. J Immunol. 2000 Feb 1;164(3):1399-1407. http://www.jimmunol.org/content/164/3/1399.long.
Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease: Crohn’s disease cA2 study group. N Engl J Med. 1997 Oct 9;337(15):1029-1035. https://www.nejm.org/doi/full/10.1056/NEJM199710093371502.
Yang H, Rotter JI, Toyoda H, Landers C, Tyran D, McElree CK, Targan SR. Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA Class II) and subclinical (antineutrophil cytoplasmic antibodies) markers. J Clin Invest. 1993 Aug;92(2):1080-1084. https://www.jci.org/articles/view/116613.
This website converts English to other languages using an automated tool called Microsoft Translator™. The translations may include errors or change the intended meaning of the text. Please consult your healthcare provider about any medical information.
Translations may not be available for some items, including PDF documents, maps, video captions, and text that appears on photos. Also, some features on the website may not work in the translated versions.
This Web page converts English to other languages â â using an automated tool called Microsoft Translatorâ ¢. Translations may include errors or change the intended meaning of the text. Please consult your doctor about any medical information.
Translations may not be available for some articles, including PDF documents, maps, video legends and text that appears in the photos. Also, some of the features on the website may not work in the translated versions.