Vatine G, Al-Ahmad A, Barriga B, Svendsen S, Salim A, Garcia L, Garcia V, Ho R, Yucer N, Qian T, Lim R, Wu J, Thompson L, Spivia W, Chen Z, Van Eyke J, Palecek S, Refetoff S, Shuster E and Svendsen CN. (2017) Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier. Cell Stem Cell 20(6): 831-843. https://www.sciencedirect.com/science/article/pii/S1934590917301261?via%3Dihub.
Rushton D, Andres P, Allred P, Baloh R and Svendsen CN. Patients with ALS show highly correlated progression rates in left and right limb muscles. (2017) Neurology 89(2):196-206. http://n.neurology.org/content/89/2/196.long.
The Huntington’s Disease iPSC Consortium (2017) Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience 30(5):648-660. http://www.nature.com/articles/nn.4532.
Ho R, Sances S, Gowing G, Amoroso MW, O’Roarke JG, Shabian A, Wichterle H, Baloh RH, Sareen D and Svendsen CN. (2016) ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nature Neuroscience 19(9):1256-67. http://www.nature.com/articles/nn.4345.
Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Change CD, Vit JP, Shelley B, Gowing G and Svendsen CN. (2016) Human neural progenitors differentiate into astrocytes and protect motor
Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016 Mar 29;16(4):542-553. http://www.nature.com/neuro/journal/v19/n4/full/nn.4273.html.
Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. Acute traumatic brain injury does not exacerbate amyotrophic lateral sclerosis in the SOD1 (G93A) rat model(1,2,3). eNeuro. 2015;2(3). pii: ENEURO.0059-14.2015. http://eneuro.org/content/2/3/ENEURO.0059-14.2015.
Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, Svendsen CN. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015;24(11):3257-3271. http://hmg.oxfordjournals.org/content/24/11/3257.
Lu B, Lin Y, Tsai Y, Girman S, Adamus G, Jones MK, Shelley B, Svendsen CN, Wang S. A subsequent human neural progenitor transplant into the degenerate retina does not compromise initial graft survival or therapeutic efficacy. Transl Vis Sci Technol. 2015;4(1):7. http://tvst.arvojournals.org/article.aspx?articleid=2212987.
Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med.2014;6(268):268ra178. http://stm.sciencemag.org/content/6/268/268ra178.
Thomsen GM, Gowing, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK and Svendsen CN. (2014) Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after Suppression of mutant SOD1 in the motor cortex. J Neurosci. 34: 15587-600. http://www.jneurosci.org/content/34/47/15587.long.
Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L and Svendsen CN. (2014) Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate in the rodent spinal cord. J Comp Neurol. 522: 2707-28. https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.23578.
Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN* and Heywood P. (2003) Direct brain infusion of glial cell line-derived neurotrophic factor (GDNF) in Parkinson's Disease. Nature Medicine 9: 589-595. PMID: 12669033. *Corresponding Author
Svendsen CN, Kew J, Staley K and Sofroniew MV. (1994) Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci. 14: 75-87. http://www.jneurosci.org/content/14/1/75.long.
Sofroneiw MV, Galletely NP, Isacson O and Svendsen CN. (1990) Survival of adult basal forebrain cholingergic neurons after loss of target neurons. Science 247: 338-342.
Thomsen G, Avalos P, Ma A, Alkaslasi M, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz, K, Svendsen CN. Transplantation of neural progenitor cells expressing GDNF into the motor cortex as a strategy to treat amyotrophic lateral sclerosis. Stem Cells
This website converts English to other languages using an automated tool called Microsoft Translator™. The translations may include errors or change the intended meaning of the text. Please consult your healthcare provider about any medical information.
Translations may not be available for some items, including PDF documents, maps, video captions, and text that appears on photos. Also, some features on the website may not work in the translated versions.
This Web page converts English to other languages â â using an automated tool called Microsoft Translatorâ ¢. Translations may include errors or change the intended meaning of the text. Please consult your doctor about any medical information.
Translations may not be available for some articles, including PDF documents, maps, video legends and text that appears in the photos. Also, some of the features on the website may not work in the translated versions.