Shaw Lab

The Shaw Laboratory is located within the Smidt Heart Institute and is focused on understanding the cell biology of heart arrhythmias and heart failure progression. Members of the lab study how cardiac ion channels are formed and how channels are targeted to specific subdomains of cardiac cell membrane in both healthy and failing heart muscle. Shaw Lab researchers combine a broad spectrum of backgrounds from talented basic scientists to medical students and clinical cardiologists. The lab research includes the mechanisms of RNA translation, cytoskeleton-based delivery of channels, the mechanisms of heart failure progression, and clinical studies of patients with heart failure. This "cell to bedside" approach is designed to develop novel diagnostics and therapeutics for failing hearts.

The Shaw Laboratory is affiliated with the Smidt Heart Institute and Department of Medicine.

The basic function of the heart is to work as a pump, circulating blood throughout the body. For each successful heartbeat, billions of individual heart cells must contract successfully and in coordinated fashion. A biological electrical system based on ion channels exists to regulate contraction and synchronization.

Collaborations & Resources

Reagents and Resources
Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Shaw Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Xie Y, Hitzeman TC, Zadikany RH, Nikolova AP, Baum R, Xu B, Agvanian S, Melmed GY, McGovern DT, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong TT, Shaw RM

Preprints. Online January 7, 2018.

Nikolova AP, Hitzeman TC, Baum R, Xu B, Agvanian S, Xie Y, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong TT, Shaw RM.

Preprints. Online January 7, 2018. 

Basheer WA, Xiao S, Epifantseva I, Fu Y, Kleber AG, Hong TT, Shaw RM.

Circ Res. 2017 Oct 13;121(9):1069-1080.

Contact the Shaw Lab

8700 Beverly Blvd.
Davis Building, Room 1016
Los Angeles, California 90048