I am a neurologist with specialty board certification in vascular neurology. I have a laboratory effort funded by the National Institutes of Health (NIH), VA and American Heart Association focused on translational preclinical stroke modeling, pharmacology and vascular biology. Our lab has recently focused on the role of thrombin mediating cytotoxicity in the brain and the molecular mechanisms of protease activated receptors (PAR)-1-mediated neuroprotection."
Thrombin is a serine protease that plays a critical role in coagulation in distal microvessels. In addition, thrombin has pleiotropic extravascular effects. It can induce protection at low doses but act as a neurotoxin at high doses, killing cells via the protease-activated receptors (PAR). Using a protease activatable cell-penetrating probe, the Lyden Laboratory has shown directly that thrombin protease activity participates in damaging the neurovascular unit.
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Lyden Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Lyden PD, Lamb J, Kothari S, Toossi S, Boitano P, Rajput PS.
J Cereb Blood Flow Metab. 2018 Nov 21;271678X18814614.
Lamb JA, Rajput PS, Lyden PD.
J Neurosci Methods. 2016 Jul 15;267:55-56.
Schlick KH, Hemmen TM, Lyden PD.
Ther Hypothermia Temp Manag. 2015 Dec;5(4):223-227.