Knudsen Lab

A. Normal prostate tissue stained with E-cadherin, CK18 and DAPI. 

B. Adrenal gland stained with E-cadherin.

C. Prostate cancer metastasis to bone marrow (H&E image).

We demonstrated, for the first time in patients with prostate cancer, a significant reduction of CDCP1 protein expression in metastatic relative to primary tumor tissues, concordant with gene expression levels in ONCOMINE and TCGA data sets. To investigate how the loss of CDCP1 facilitates prostate cancer metastasis, we determined the consequences of CDCP1 loss in nonadherent cancer cells, which provide an experimental model system of circulating tumor cells (CTC). 

Collaborations

Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Knudsen Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Publications

Das L, Anderson TA, Gard JM, Sroka IC, Strautman SR, Nagle RB, Morrissey C, Knudsen BS, Cress AE.

J Cell Biochem. 2016 Aug 10.

Vidal AC, Chen Z, Howard LE, Moreira DM, Castro-Santamaria R, Andriole GL, Taioli E, Fowke JH, Knudsen B, Drake CG, et al.

Oncotarget. 2016 Jul 18.

You S, Knudsen BS, Erho N, Alshalalfa M, Takhar M, Al-Deen Ashab H, Davicioni E, Karnes RJ, Klein EA, Den RB, et al. 

Cancer Res. 2016 Sep 1;76(17):4948-4958.

Contact the Knudsen Lab

8700 Beverly Blvd.
Davis Building, Lab 5094G
Los Angeles, CA 90048