We demonstrated, for the first time in patients with prostate cancer, a significant reduction of CDCP1 protein expression in metastatic relative to primary tumor tissues, concordant with gene expression levels in ONCOMINE and TCGA data sets. To investigate how the loss of CDCP1 facilitates prostate cancer metastasis, we determined the consequences of CDCP1 loss in nonadherent cancer cells, which provide an experimental model system of circulating tumor cells (CTC).
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Das L, Anderson TA, Gard JM, Sroka IC, Strautman SR, Nagle RB, Morrissey C, Knudsen BS, Cress AE.
J Cell Biochem. 2016 Aug 10.
Vidal AC, Chen Z, Howard LE, Moreira DM, Castro-Santamaria R, Andriole GL, Taioli E, Fowke JH, Knudsen B, Drake CG, et al.
Oncotarget. 2016 Jul 18.
You S, Knudsen BS, Erho N, Alshalalfa M, Takhar M, Al-Deen Ashab H, Davicioni E, Karnes RJ, Klein EA, Den RB, et al.
Cancer Res. 2016 Sep 1;76(17):4948-4958.