Recent evidence from the Di Vizio Laboratory indicates that fast migrating and metastatic amoeboid cancer cells undergoing non-apoptotic membrane blebbing can shed bioactive extracellular vesicles (EVs), namely large oncosomes, into the extracellular space due to their atypically large size in comparison with other classes of EVs.
Specific areas of study include:
- The role of large oncosomes in intercellular communication and in tumor growth and metastasis in prostate and breast cancers
- Molecular mechanisms regulating the function of specific miRNA cargo of large oncosomes in breast and lung cancer progression
- Molecular profiling of large oncosomes and other cancer-derived EVs by next generation sequencing and proteomics in prostate and breast cancer and in glioblastoma
- Molecular mechanisms and functional consequences of the internalization of large oncosomes in recipient cells
In a separate line of research, we are investigating the function of caveolin-1 in the prostate cancer stroma, with particular emphasis on the clinical significance of caveolin-1 loss with tumor progression and on the regulation of intracrine production of stromal androgens as a novel mechanism to cross-talk with the tumor cells.