Recent evidence from the Di Vizio Laboratory indicates that fast migrating and metastatic amoeboid cancer cells undergoing non-apoptotic membrane blebbing can shed bioactive extracellular vesicles (EVs), namely large oncosomes, into the extracellular space due to their atypically large size in comparison with other classes of EVs.
- The role of large oncosomes in intercellular communication and in tumor growth and metastasis in prostate and breast cancers
- Molecular mechanisms regulating the function of specific miRNA cargo of large oncosomes in breast and lung cancer progression
- Molecular profiling of large oncosomes and other cancer-derived EVs by next generation sequencing and proteomics in prostate and breast cancer and in glioblastoma
- Molecular mechanisms and functional consequences of the internalization of large oncosomes in recipient cells
In a separate line of research, we are investigating the function of caveolin-1 in the prostate cancer stroma, with particular emphasis on the clinical significance of caveolin-1 loss with tumor progression and on the regulation of intracrine production of stromal androgens as a novel mechanism to cross-talk with the tumor cells.