Dharmakumar Lab

Translational Cardiac Imaging Research
Mission

The Dharmakumar Laboratory is led by Rohan Dharmakumar, PhD, Associate Director of the Biomedical Imaging Research Institute. The mission of the program is to develop diagnostic and therapeutic strategies in the fight against cardiovascular diseases, using a multifaceted interdisciplinary approach. Employing noninvasive, leading-edge imaging methods, the program strives to create synergies in basic science research and build a rigorous scientific basis for rapid translation of preclinical findings to clinical patient care.

Focus

Ischemic heart disease, a class of diseases that stems from reduced oxygen supply to the heart muscle, is the most common cause of death in western countries. The focus of the program is to better understand ischemic heart disease using sophisticated imaging technologies, particularly MRI and PET.

Key areas of active research:

  • Imaging based interrogation of myocardial oxygenation
  • Cardiac stress testing with inhalational CO2
  • Noninvasive characterization of myocardial infarction
  • Post-infarction iron and its relation to cardiac arrhythmias
  • Myocardial bleeding and risk of heart failure
  • Magnetic targeting of therapeutic substrates
  • Integrated PET and MRI for ischemic heart disease
Key Research Achievements
  • Imaging-based interrogation of myocardial oxygenation
  • Cardiac stress testing with inhalational CO2
  • Noninvasive characterization of myocardial infarction
  • Post-infarction iron and its relation to cardiac arrhythmias
  • Myocardial bleeding and risk of heart failure
  • Magnetic targeting of therapeutic substrates
  • Integrated PET and MRI for ischemic heart disease
Collaborations

External
  • Louis Bouchard, PhD, UCLA
  • Joseph Fisher, MD, University of Toronto
  • Chang Hyuk-Jae, Yonsei University
  • Warren Jackman, MD, Oklahoma Health Sciences Center
  • James Min, MD, Cornell University
  • Frank Prato, PhD, University of Western Ontario
  • Sotirios Tsaftaris, PhD, IMT Lucca, Italy
  • James White, MD, University of Calgary
  • Multi-center MIRON Investigators
Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Dharmakumar Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Contact the Dharmakumar Lab

116 N. Robertson Blvd.
Pacific Theatres Building, Suite 800
Los Angeles, CA 90048