Medically Associated Science and Technology (MAST) Program

The Medically Associated Science and Technology (MAST) program at Cedars-Sinai is dedicated to the development of novel drugs and devices to diagnose and treat patients. MAST represents the main sail of a vessel taking us on a voyage of discovery in medicine and science. This innovative program is working to develop new diagnostics and therapeutics to treat patients with illnesses related to imbalances or alterations in the microbiome. Over the last 20 years, the MAST team has made many discoveries that benefit millions of patients, and we hope to help millions more with our growing fleet of novel diagnostics and therapeutics.

The MAST team accomplishes our research by using innovative new technologies that allow us to bring bench-side scientific discoveries to the bedside and beyond—to the healthcare community. Current MAST efforts focus on discovering technologies to diagnose and treat microbiome-based conditions, particularly in the areas of metabolic disorders and gastrointestinal functional and motility disorders.

At MAST, patients are at the center of our work, which gives us a unique perspective as we innovate. Having direct interactions with patients drives our curiosity toward clinically meaningful questions and allows us to move quickly toward identifiable solutions. The MAST team brings expertise in working with the microbiome in both basic and clinical aspects, along with a track record of navigating the U.S. Food and Drug Administration (FDA) approval process and post-FDA approval work.

New Breath Test Diagnostics

Irritable bowel syndrome and small intestinal bacterial overgrowth have similar symptoms yet require different treatments—a new test can provide more accurate diagnosis.

Making Diabetes Easier to Treat

New insights into bariatric surgery, insulin pump technology, microbiome connection and insulin clearance present opportunities for diabetes research and treatments.

Deepening Comprehension of Digestive Diseases

Research breakthroughs in gut microbiome and other digestive diseases help experts improve diagnostic tools and protocols.

Featured Researcher

Discovery best happens at the bedside of patients by doctors and not just in a pharmaceutical lab."


Mark Pimentel, MD


Groundbreaking Developments at MAST


The Medically Associated Science and Technology (MAST) program is dedicated to the development of novel drugs and devices to diagnose and treat patients in microbiome-based conditions. MAST is pleased to announce a novel development that affects the areas of gastrointestinal functional and motility disorder diagnosis and treatment.

Small Intestine Aspirate Tool

Tools are needed for evaluating the human microbiome, and numerous challenges have needed to be overcome to study the microbiome of the small intestine. One challenge has been that the amount of fluid that can be aspirated from this area is limited. Typical catheters are contaminated as they traverse the endoscope through which these samples are obtained. In collaboration with Hobbs Medical, Cedars-Sinai scientists have developed a novel system for quickly and easily obtaining small intestine aspirates. This new system will become integral to the study of the small intestine in relationship to the microbiome.


Contact the Medically Associated Science and Technology (MAST) Program
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