In preclinical and clinical trials, Cedars-Sinai investigators develop novel, minimally invasive techniques—including hybrid approaches and imaging modalities—for improving outcomes and minimizing cumulative trauma to congenital heart patients.
In preclinical research, investigators study the use of new transcatheter valve implantations as well as technology and therapies that translate into clinical methods for the treatment of congenital heart disease.
Cedars-Sinai researchers develop and implement catheterization and cardiovascular surgical intervention procedures in clinical trials to treat complex congenital problems. Researchers currently participate in the following clinical research projects:
Fontan Udenafil Exercise Longitudinal (FUEL) Trial and the FUEL Open-Label Extension Trial: These trials are designed to determine the effect of udenafil, a novel PDE5 inhibitor, on exercise performance in the Fontan population over a six-month period, and to study the longer-term safety of udenafil over an additional 12 months. While exercise is the primary outcome, we will also evaluate the effect of udenafil on echo measures of ventricular function, serum biomarkers, endothelial function, and measures of quality of life. This is a Pediatric Heart Network, multicenter trial sponsored by the National Heart, Lung, and Blood Institute.
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This Web page converts English to other languages â â using an automated tool called Microsoft Translatorâ ¢. Translations may include errors or change the intended meaning of the text. Please consult your doctor about any medical information.
Translations may not be available for some articles, including PDF documents, maps, video legends and text that appears in the photos. Also, some of the features on the website may not work in the translated versions.