Meet Our Director
One of Freedland’s early papers compared prostate cancer in obese participants to prostate cancer in participants with healthy weights, finding a relationship between the severity of the cancer and the weight of the participant. This created a, "huh, that’s interesting," moment for Freedland, who returned in future studies to the role of weight in prostate cancer.
As his career progressed, Freedland observed that lifestyle factors were not being researched rigorously, and compelling research results on these issues were not being communicated efficiently or regularly to the public. CIRCL is the result of these observations.
Without setting out to do it, Freedland has built on the legacy of his father’s research in nutrition. At CIRCL, Freedland has developed a focused team that collaboratively and rigorously researches how nutrition and other lifestyle factors influence cancer risk and progression. CIRCL is participating in four clinical trials focusing on diet and exercise, and numerous trials focusing on stress management, with more in the pipeline. In the coming year, Freedland plans to build the CIRCL team (adding directors of translational science and clinical trials) and to expand the basic science studies to better understand the mechanisms of the influence of lifestyle on cancer.
It is clear to Freedland that the coming year will be challenging, but he finds this motivating. According to Freedland, "It is clear that genes load the gun but lifestyle pulls the trigger. Now we just need to figure out how to un-pull the trigger."
Contact us if you have questions, or wish to learn more about integrated research in cancer and lifestyle research at Cedars-Sinai.
8631 W. Third St.
Fourth Floor, Suite 430E
Los Angeles, CA 90048