Frequently Asked Questions
Induced pluripotent stem cells are adult cells that have been genetically reprogrammed to an embryonic stem cell-like state. This is achieved by forcing the cells to express genes and factors important for maintaining the defining properties of embryonic stem cells.
Human iPSCs are unprecedented tools for the study of human development, cell fate programming, tissue regeneration and drug development. They are also used to produce many human system cell types for studying human development and other biological investigations.
The RMI iPSC Core generates "footprint free" iPSCs by transfecting parent cells with non-integrating oriP/EBNA1 plasmids that rely on episomal expression of reprogramming factors.
The RMI iPSC Core can reprogram various human somatic tissues including fibroblast, lymphoblastoid cell lines, corneal epithelial cells, primary keratocytes, adipose stem cells, mammary epithelial cells and whole blood.