Joshua I. Goldhaber, MD
- The doctor practices in an office or specialty that we currently do not survey.
- The doctor has not yet received the minimum number of patient satisfaction surveys (30) to be eligible for display.
310-423-2726
- The doctor practices in an office or specialty that we currently do not survey.
- The doctor has not yet received the minimum number of patient satisfaction surveys (30) to be eligible for display.
Joshua I. Goldhaber, MD
Scheduling
In person visits
Smidt Heart Institute
127 S San Vicente Blvd #A3600
Los Angeles, CA
34.074653 -118.378972From You
- The doctor practices in an office or specialty that we currently do not survey.
- The doctor has not yet received the minimum number of patient satisfaction surveys (30) to be eligible for display.
Joshua I. Goldhaber, MD
Languages
- English,
Gender
Male
Experience
38 Years
Locations
Experience
Specialties
Area in which a healthcare provider is highly trained and often board certified.
1
- IM Cardiology
Programs
Cedars-Sinai clinical programs this provider is part of:
2
Research Areas
The Goldhaber laboratory studies the regulation of cardiac contractility and sinoatrial node activity. Abnormal contractile function is a key feature of heart failure, a condition which affects over 5 million Americans and is a major driver of health care costs. Sinus node dysfunction is another common disease, which is responsible for 200,000 permanent pacemaker implantations every year and which also contributes to conditions such as atrial fibrillation. Both heart failure and sinus node disease are caused in part by abnormal intracellular calcium cycling. The Goldhaber laboratory studies the basic mechanisms of intracellular calcium cycling, particularly the role of the sodium-calcium exchange transporter, on cardiac muscle contractility and sinus node function. The sodium-calcium exchanger is an electrogenic transporter located on the surface membrane of cardiac cells. It is considered to be the dominant calcium efflux transport mechanism in cardiac cells. The Goldhaber laboratory uses specialized techniques in multiple complementary biological models to study the interaction between calcium regulation and molecular transporter structure/function, ion channel biophysics, calcium signaling and cellular electrophysiology. Methodology includes high speed laser scanning confocal microscopy, voltage mapping, conventional patch clamp, mutagenesis and giant patch.
Titles
- Director, Division of Applied Cell Biology and Physiology
- Dorothy and E. Phillip Lyon Chair, Laser Research
- Associate Director, Coronary Intensive Care Unit
- Director, Basic Research in the Heart Institute
Education & Training
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UCLA Medical Center, Los Angeles, CA
Fellowship - Completed 1990
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UCLA Medical Center, Los Angeles, CA
Residency - Completed 1987
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UCLA Medical Center, Los Angeles, CA
Internship - Completed 1985
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Harvard Medical School
Medical School - Completed 1984
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Harvard College
Degrees - Completed 1980
Achievements
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2
Board Certifications
-
6
Awards and Honors
-
6
Publications
Board Certifications
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IM/Cardiology
American Board of Internal Medicine
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General Internal Medicine
American Board of Internal Medicine
Awards and Honors
- Alpha Omega Alpha
- President, Western Association of Physicians
- Dorothy and E. Phillip Lyon Chair in Laser Research
- Fellow, American College of Cardiology
- President, Western Society of Clniical Investigation
- Elected Member, Association of University Cardiologists
Publications
A full list of this provider’s research publications can be found on their research profile or PubMed.
- Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity. PLoS One. 8:e81633. 2013.
- Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI: Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophys. J., 99(3): 755-64, 2010
- Goldhaber JI, Hamilton MA: Role of inotropic agents in the treatment of heart failure. Circulation, 121(14): 1655-60, 2010
- Chantawansri C, Huynh N, Yamanaka J, Garfinkel A, Lamp ST, Inoue M, Bridge JH, Goldhaber JI: Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes. Biophys. J., 94(5): 1656-66, 2007
- Fukumoto GH, Lamp ST, Motter C, Bridge JH, Garfinkel A, Goldhaber JI: Metabolic inhibition alters subcellular calcium release patterns in rat ventricular myocytes: implications for defective excitation-contraction coupling during cardiac ischemia and failure. Circ. Res., 96(5): 551-7, 2005
- Reuter H, Han T, Motter C, Philipson KD, Goldhaber JI: Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling. J. Physiol. (Lond.), 554(Pt 3): 779-89, 2003