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Arun Sharma, PhD

Arun Sharma, PhD

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  • The doctor practices in an office or specialty that we currently do not survey.
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Arun Sharma, PhD
No patient rating & comments. Why?
  • The doctor practices in an office or specialty that we currently do not survey.
  • The doctor has not yet received the minimum number of patient satisfaction surveys (30) to be eligible for display.

Arun Sharma, PhD

No patient rating & comments. Why?
  • The doctor practices in an office or specialty that we currently do not survey.
  • The doctor has not yet received the minimum number of patient satisfaction surveys (30) to be eligible for display.
Arun Sharma, PhD

Arun Sharma, PhD

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Languages

  • English,

Gender

Male

Experience

Programs

Cedars-Sinai clinical programs this provider is part of:

1

Research Areas

Research in the laboratory of Arun Sharma, PhD, focuses on the applications of human induced pluripotent stem cells (hiPSCs) for modeling cardiovascular diseases in-vitro. The lab utilizes cutting-edge technologies including hiPSCs, CRISPR/Cas9 genome editing, cardiac microfluidic organ-chips, and cardiac organoids in studies aiming to understand the molecular mechanisms driving cardiovascular diseases. For example, the Sharma laboratory employs hiPSC-derived cardiomyocytes (personalized, beating heart muscle cells) to model cardiac viral infections occurring during COVID-19, to examine the developmental mechanisms underlying congenital heart disease, and to understand ways to alleviate the cardiovascular toxicities caused by chemotherapeutic agents. The Sharma lab also has a unique background and interest in space biology, and investigates means by which stem cell biology can intersect with this emerging field.

Titles

  • Assistant Professor, Department of Biomedical Sciences
  • Research Scientist I, Regenerative Medicine Institute

Education & Training

  • Cedars-Sinai Medical Center, Postdoctoral Fellowship, Multi-Lineage Disease Modeling

    Fellowship - Completed 2021

  • Harvard Medical School, Postdoctoral Fellowship, Cardiovascular Genetics

    Fellowship - Completed 2019

  • Stanford University, PhD, Stem Cell Biology and Regenerative Medicine

    Degrees - Completed 2016

  • Duke University, BS, Biology

    Degrees - Completed 2012

Achievements

  • 5

    Awards and Honors

  • 10

    Publications

Awards and Honors

  • COVID-19 Rapid Response Award, American Heart Association
  • Career Development Award, American Heart Association
  • Graduate Research Fellowship, National Science Foundation
  • Predoctoral Research Fellowship, American Heart Association
  • Forbes 30 Under 30 List in Science, Forbes Magazine

Publications

A full list of this provider’s research publications can be found on their research profile or PubMed.

  • Sharma, A., Marceau, C., Hamaguchi, R., Burridge, P., Rajarajan, K., Churko, J., Wu, H., Sallam, K., Matsa, E., Sturzu, A., Che, Y., Ebert, A., Diecke, S., Liang, P., Red-Horse, K., Carette, J., Wu, SM., Wu, JC. “Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model for Coxsackievirus B3-Induced Viral Myocarditis”. Circulation Research. 2014. 115 (6): 556-566.
  • Sharma, A., Burridge, PW., McKeithan, WL., Serrano, R., Shukla, P., Sayed, N., Churko, JM., Kitani, T., Wu, H., Holmstrom, A., Matsa, E., Zhang, Y., Kumar, A., Fan, AC., del Alamo, JC., Wu, SM., Moslehi, JJ., Mercola, M., Wu, JC. “High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells.” Science Translational Medicine. 2017. 9(377). eaaf2584.
  • Sharma, A., McKeithan, W.L., Serrano, R., Kitani, T., Burridge, P.W., del Alamo, JC., Mercola, M., Wu, J.C. “Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Assess Drug Cardiotoxicity.” Nature Protocols. 2018. 13, 3018-3041.
  • Sharma, A., Toepfer, C. N., Ward, T., Wasson, L., Agarwal, R., Conner, D. A., Hu, J. H., Seidman, C. E. “CRISPR/Cas9-mediated fluorescent tagging of endogenous proteins in human pluripotent stem cells.” Current Protocols in Human Genetics. 2018. 96, 21.11.1–21.11.20.
  • Toepfer, CN*, Sharma, A.*, Cicconet, M., Garfinkel, AC., Mucke, M., Neyazi, M., Willcox, JAL., Agarwal, R., Schmid, M., Rao, J., Ewoldt, JK., Pourquie, O., Chopra, A., Chen, C., Seidman, JG., Seidman, CE. “SarcTrack: An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes.” Circulation Research. 2019. 124(8):1172-1183. *Equal Contribution
  • Wnorowski, A*., Sharma, A.*, Chen, H., Wu, H., Shao, N., Sayed, N., Liu, C., Countryman, S., Stodieck, LS., Rubins, KH., Wu, SM., Lee, PHU., Wu, JC. “Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function.” Stem Cell Reports. 2019. 13(6):960-969. *Equal Contribution
  • Sharma, A., Sances, S., Workman, MJ., Svendsen, CN. “Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery.” Cell Stem Cell. 2020;26(3):309-29.
  • Sharma A., Wasson LK, Willcox JA, Morton SU, Gorham JM, DeLaughter DM, Neyazi M, Schmid M, Agarwal R, Jang MY, Toepfer CN, Ward T, Kim Y, Pereira AC, DePalma SR, Tai A, Kim S, Conner D, Bernstein D, Gelb BD, Chung WK, Goldmuntz E, Porter G, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE; Pediatric Cardiac Genomics Consortium. “GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm.” eLife. 2020. Oct 15;9:e53278.
  • Sharma, A. “Stem cells to help the heart.” Science. 2020. 367 (6483): 1206.
  • Sharma, A.#, Garcia, G., Wang, Y., Plummer, JT., Morizono, K., Arumugaswami, V.#, Svendsen, CN#. (2020). “Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection.” Cell Reports Medicine. 2021. 1 (4), 100052. #Co-corresponding author