Pathobiology of Lupus Heart Disease

Condition: Lupus heart disease


Key Inclusion Criteria

  • Adult female lupus patients who are 30-55 years old with signs or symptoms concerning for ischemia and meeting criteria for lupus
  • Ability to give informed consent

Key Exclusion Criteria

  • History or documented evidence of obstructive coronary artery disease
  • Acute coronary syndrome, myocardial infarction or stroke in the past 
  • Primary valvular heart disease with need for valve repair or replacement

Full Study Name

Inflammation and Metabolic Reprogramming of Lupus Monocytes – Mechanisms of the Pathobiology of Lupus Cardiovascular Disease (IRB no. 54998)


This study focuses on female lupus patients with symptoms of cardiac ischemia. The purpose of the study is to define the pathways of heart disease or cardiovascular disease in patients with lupus. The study will combine cardiac imaging techniques with analysis of immune cells from lupus patients to potentially identify a cure and improve quality of life for individuals who are affected by the disease.

Studies indicate that cardiac magnetic resonance imaging can noninvasively identify and characterize coronary microvascular dysfunction. Cardiac computed tomography will be used to document absence of obstructive coronary artery disease. Researchers will collect medical history and quality of life questionnaires, as well as blood, urine, electrocardiogram and cardiac imaging (computed tomography and magnetic resonance imaging) and will combine this information with analysis of how active the immune cells are. It is hoped that this study will not only provide much-needed information on lupus-related cardiac disease but may also determine whether there are markers that could be helpful in assessing lupus-specific pathways that affect cardiac disease.

Principal Investigator

Caroline Jefferies, PhD

Bryan Gonzalez