Obstetrics Clinical Trials

Researchers and maternalhealth specialists at Cedars-Sinai conduct clinical trials to gain knowledge so that they may help women achieve the best possible outcomes for themselves and their babies. 

Questions? See the Clinical Trial FAQs.

Condition:

  • Perinatal depression

Key Inclusion Criteria:

  • Women at least 18 years old who delivered their baby at Cedars-Sinai
  • English speaking
  • Patient in the Maternal Fetal Care Unit (MFCU) who has a maternal medical condition requiring hospital admission
  • Patient whose baby is in Neonatal Intensive Care Unit (NICU) at least two weeks

Summary:
This study focuses on patients who are pregnant or postpartum and who are currently admitted to the Cedars Sinai Maternal Fetal Care Unit/Neonatal Intensive Care Unit (MFCU/NICU) or Surgical Intensive Care Unit (SICU), or whose baby has been admitted to the NICU. The study is designed to investigate the variation in preferences and need for mental health services in women who experience an adverse pregnancy outcome and require additional treatment in the MFCU/ICU or whose babies require treatment in the NICU.

Additionally, researchers aim to understand how mental health screening and evaluation can help women reduce their risk of developing postpartum depression. Evaluating the effectiveness of this mental health screening, education and referral program at Cedars-Sinai will provide valuable patient-centered data that can be used in future clinical care services planning. Participants will be asked to complete questionnaires, and medical records will be reviewed.

Condition:

  • Preeclampsia and Perinatal Mood and Anxiety Disorders

Key Inclusion Criteria:

  • At least 18 years old
  • Women who experience gestational hypertension or preeclampsia with or without severe features

Summary:
This study focuses on patients who are pregnant and in their third trimester of pregnancy. The purpose of the study is to evaluate the anti-inflammatory role of vitamin D in reproductive-aged women and its association with gestational hypertension, preeclampsia and depression. Researchers aim to provide new information implicated in the development of preeclampsia (a condition that may include hypertension, tissue swelling and kidney stress) and postpartum depression.

Additionally, the study is designed to understand how early mental health screening and evaluation can help pregnant women reduce their risk of developing postpartum depression. Evaluating the effectiveness of this mental health screening, education and referral program at Cedars-Sinai will provide valuable patient-centered data that may be used in future services planning. Data will be collected from medical records, and participants will be asked to complete questionnaires, among other research procedures.

Condition:

  • Obstetrics

Key Inclusion Criteria:

  • Pregnant women who have been scheduled for a genetic counseling, chorionic villus sampling (CVS), amniocentesis, ultrasound and/or for clinical reasons
  • Offspring of the pregnant women who have participated in this study
  • Biological father of the offspring that is the product of current pregnancy

Summary:
This study focuses on pregnant patients. The purpose of the Prenatal Repository is to gather tissue samples and data to investigate causes of pregnancy complications, such as delivering a premature or small baby and developing diabetes or hypertension during pregnancy. By collecting this information, researchers can explore the possibility of developing new methods of prenatal diagnosis that may be completed earlier or less invasively to identify women at risk. Additionally, samples and clinical information collected as part of this repository may be used to support future research that aims to further scientific knowledge about prenatal development.

Researchers will ask to include participants' babies (by obtaining information from the babies' medical records) and attempt to enroll the biological father of the babies. The biological fathers willing to participate will be contacted through the mother.

Condition:

  • Prenatal diagnosis

Key Inclusion Criteria:

  • Female who is at least 8 weeks pregnant and no more than 26 weeks gestation
  • At least 18 years old
  • At increased risk for fetal chromosomal abnormalities (abnormalities of the fetus)

Summary:
This study focuses on patients who will undergo chorionic villus sampling (CVS) or amniocentesis (amnio) and who are at increased risk for having fetal aneuploidy (chromosomal abnormalities in the fetus). The study is designed to evaluate the investigational use of an in vitro diagnostic test called SEQureDx Trisomy 21. Researchers will compare SEQureDx Trisomy 21 to existing tests in order to learn more about the detection of fetal aneuploidy. CVS or amnio procedures are both invasive procedures and can carry an increased risk of complications. Researchers are conducting this study to help develop a new, noninvasive test.

Condition:

  • Adverse pregnancy outcome and cardiovascular health

Key Inclusion Criteria:

  • Women who experience an adverse pregnancy outcome including gestational diabetes, hypertension, preeclampsia, preterm delivery and/or growth-restricted newborn
  • Women who are at least 18 years old

Summary:
This study focuses on women who have experienced an adverse pregnancy outcome (complications during pregnancy), including hypertension, gestational diabetes, small-for-gestation-age baby and/or preterm delivery, because they all have an increased risk of developing later cardiovascular disease, including heart attacks and strokes. The purpose of the study is to determine if early cardiovascular screening and evaluation can help these women reduce their long-term risk of developing heart disease. The registry will allow researchers to track the course of potential cardiovascular problems in women with adverse pregnancy outcomes to ultimately identify women who need intervention to help prevent cardiovascular disease, as well as study the association between adverse pregnancy outcomes, mental health and cardiovascular health.

Data will be collected from medical records, and participants will be asked to complete mental health questionnaires, among other research procedures.

Condition:

  • Pregnancy and childbirth

Key Inclusion Criteria:

  • Pregnant women (approximately 36 weeks) and recently pregnant women (approximately 8 weeks postpartum)

Summary:

This study focuses on pregnant women (approximately 36 weeks) and recently pregnant women (approximately 8 weeks postpartum). The purpose of the study is to understand what women want in childbirth and how satisfied they are with the hospital care experience. Participants will be asked about their preferences and expectations for services and outcomes for childbirth. The survey results will be used to identify the most important preferences women have for childbirth and the services they received during their hospital stay. Results will also be used to help hospitals find ways to be more responsive to women's preferences and to improve patient satisfaction. 

The study involves two surveys. The first survey will occur approximately one month before the participant’s due date. It will inquire about pregnancy history and what kind of services the participant would like to receive in the hospital for childbirth. The second survey will occur approximately two months after delivery; it will ask about what happened in the hospital during delivery. 

Financial disclosure: Fridman Moshe, MD, and Lisa Korst, MD, who are non-Cedars-Sinai participating investigators on this study, may receive compensation, equity interests, royalty income or the right to receive future royalties under a patent or copyright where the research is directly related to the work.