Preoperative fMRI in Patients With Epilepsy7

Condition: Epilepsy

Eligibility

Key Inclusion Criteria

  • Patients with drug-resistant focal epilepsy who have agreed to undergo monitoring with implanted depth electrodes in the future

Key Exclusion Criteria

  • Pregnancy
  • Unable to undergo an MRI
  • Children younger than 16 years old

Full Study Name

Pre-operative Structural and Functional Magnetic Resonance Imaging in Patients With Epilepsy (IRB no. 41693)

Summary

This study focuses on individuals who have medically intractable epilepsy (epilepsy that cannot be controlled by treatment) and who are scheduled to undergo insertion of electrodes into their brain to help find the source of seizures. The purpose of the study is to examine whether preoperative functional magnetic resonance imaging (functional MRI) can be used to help localize areas of the brain from which seizures originate. Researchers aim to determine whether functional MRI studies provide additional information beyond that provided by depth electrode monitoring (which participants will undergo as part of standard care). The study will also examine whether high-resolution structural MRIs can help localize the electrodes that patients will be implanted with at a later time.

Although the electrodes are placed to help treat the participant’s epilepsy, researchers can also record electrical activity from the electrodes to study how seizures develop and progress. This provides an opportunity to better understand how seizures are generated and how such epileptic activity interferes with how the human brain learns new things, remembers information, and processes information to make decisions.

Principal Investigator

Jeffrey Chung, MD

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