MS-Research Biomarkers (MS-ReBS)

Condition: Multiple sclerosis and related disorders (MSRD)


Key Inclusion Criteria:

  • Diagnosis of multiple sclerosis (MS), clinically isolated syndrome, radiologically isolated syndrome, neuromyelitis optica spectrum disorders, myelin oligodendrocyte glycoprotein-related disease, or neurological disorder other than MS and related disorders (MSRD)
  • Healthy volunteer
  • At least 18 years old

Key Exclusion Criteria:

  • Participants with contraindication to magnetic resonance imaging will be excluded from the optional MRI research procedures but can still participate in other aspects of the study
  • Pregnant patients will be excluded from the MRI portions of the study but can still participate in other aspects of the study
  • Patients will be excluded from the visual assessment portions of the study if they have had recent ocular surgery or eye diseases that may affect measurements

Study Name

Investigating the Longitudinal Relationships Between Visual Pathway Injury, Radiological and Blood Biomarkers in Multiple Sclerosis and Related Disorders (IRB no. 00001690)


The purpose of this study is to determine whether combining information from visual assessment and blood markers, as well as historical and ongoing magnetic resonance imaging (MRI) of the brain, orbit (the part of the skull where eyes are located), or spinal cord can predict disability progression due to neurological disease.

Researchers hope to learn whether several biomarkers (MRI scan, blood tests, or visual assessment) can correlate with long-term disability and clinical outcomes in multiple sclerosis and related disorders (MSRD) and their response to therapy. Biomarkers may be a sign of a condition or disease and can be used to predict an individual’s response to a specific treatment or risk of disability in the future.

Principal Investigator

Neuroimmunology Research Team