ICECAP

Condition: Brain injury

Eligibility

Key Inclusion Criteria:

  • Coma after resuscitation from out-of-hospital cardiac arrest
  • Cooled to <34°C within 240 minutes of cardiac arrest
  • At least 18 years old

Key Exclusion Criteria:

  • Hemodynamic instability (systolic blood pressure <80 mm Hg despite aggressive management)
  • Preexisting neurological disability or condition that confounds outcome determination
  • Preexisting terminal illness, unlikely to survive to outcome determination
     

Study Name

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (IRB no. 00000673)

Summary

Brain injury causing coma after cardiac arrest can be fatal or may prevent patients from recovering. This study focuses on comatose, adult survivors of out-of-hospital cardiac arrest who have already been rapidly cooled per standard of care. Therapeutic hypothermia (cooling the body and brain a few degrees below normal temperature) is a standard treatment in which comatose patients are rapidly cooled to improve their chances of recovery.

The purpose of the study is to determine whether different lengths of time for body cooling affect recovery; researchers want to learn more about a way to possibly lessen brain injury after cardiac arrest. Standard practice is to cool patients for about a day, but the best length of time is not known. After treatment, researchers will contact participants or their caregivers about once per month to see how the participant is doing.

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