Condition: Multiple sclerosis


Key Inclusion Criteria

  • 18-65 years old
  • Referral for a new clinical or radiological suspicion of multiple sclerosis
  • Not on disease-modifying therapy for multiple sclerosis

Key Exclusion Criteria

  • Contraindication to magnetic resonance imaging (MRI) studies, metal or metal implants incompatible with MRI
  • Unable to tolerate MRI due to claustrophobia or excessive movement related to tremor
  • Contraindication to use of gadolinium-containing contrast agents
Full Study Name

Central Vein Sign in the Early Diagnosis of Multiple Sclerosis (CAVS-MS) Pilot Study (IRB no. 56043)


The purpose of this study is to determine whether the use of an investigational magnetic resonance imaging (MRI) sequence called FLAIR* can increase the accuracy of diagnosing patients with multiple sclerosis (MS) or suspected MS. The imaging method proposed for the study has been shown to be effective for the detection of central vein sign, which is a hallmark of MS. Participants will undergo a brain magnetic resonance imaging with and without gadolinium-based contrast. The gadolinium contrast (dye) will be administered intravenously (into the patient’s blood vessel).  

Principal Investigator

Nancy Sicotte, MD