CREST 2 Study for Asymptomatic Carotid Stenosis
Condition: Carotid stenosis
Key Inclusion Criteria
- At least 35 years old
- Carotid stenosis (narrowing of carotid arteries)
- No medical history of stroke or transient ischemic attack on the same side of the body as the stenosis (narrowing) within 180 days of study group assignment
Key Exclusion Criteria
- Intolerance or allergic reaction to a study medication without a suitable management alternative
- Gastrointestinal hemorrhage within one month prior to enrollment that would prevent antiplatelet therapy (treatment to prevent the formation of blood clots)
- Prior ipsilateral stroke (stroke occurring on the same side of the body as the narrowed artery) with substantial disability that is likely to confuse study outcomes
Full Study Name
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) Protocol (IRB no. 39002)
This study evaluates differences between treatment options for patients with asymptomatic carotid stenosis (narrowing of the carotid arteries without symptoms). Carotid artery disease is caused by a thickened area (plaque) in the artery, which narrows the artery and may limit blood flow to the brain.
Researchers would like to examine outcomes in participants that receive medical management alone compared to those that receive medical management in combination with carotid endarterectomy or carotid artery stenting (surgical procedures to open the carotid artery).